Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis
Open accessAbstract
Disruption of homeostasis between the host immune system and the intestinal microbiota leads to inflammatory bowel disease (IBD). Whether IBD is instigated by individual species or disruptions of entire microbial communities remains controversial. We characterized the fecal microbial communities in the recently described T-bet(-/-) ×Rag2(-/-) ulcerative colitis (TRUC) model driven by T-bet deficiency in the innate immune system. 16S rRNA-based analysis of TRUC and Rag2(-/-) mice revealed distinctive communities that correlate with host genotype. The presence of Klebsiella pneumoniae and Proteus mirabilis correlates with colitis in TRUC animals, and these TRUC-derived strains can elicit colitis in Rag2(-/-) and WT adults but require a maternally transmitted endogenous microbial community for maximal intestinal inflammation. Cross-fostering experiments indicated a role for these organisms in maternal transmission of disease. Our findings illustrate how gut microbial communities work in concert with specific culturable colitogenic agents to cause IBD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bacteroides and Prevotella have been found to be increased in other colitis models or patients with IBD.
“We also found higher relative abundances of the genera Bacteroides and Prevotella in mice with less developed mucus, bacteria that have been found to be increased also in other colitis models or patients with IBD 39, 43.”
From The composition of the gut microbiota shapes the colon mucus barrier (2015) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Self-citationFastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602 · see citing works
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis
Cole, J., Wang, Q., Cardenas, E., Fish, J., Chai, B., Farris, R. J., Kulam-Syed-Mohideen, A., Mcgarrell, D., Marsh, T., Garrity, G., et al. (2008) · Nucleic Acids Res. · doi:10.1093/nar/gkn879 · Cited by 4,940 · see citing works
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works
Nadkarni, M. A., Martin, F. E., Jacques, N. A., & Hunter, N. (2002) · Microbiology · doi:10.1099/00221287-148-1-257 · Cited by 1,931 · see citing works
Immune adaptations that maintain homeostasis with the intestinal microbiota
Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,455 · see citing works
Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.020 · Cited by 1,452 · see citing works
Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex
Hamady, M., Walker, J. J., Harris, J. K., Gold, N. J., & Knight, R. (2008) · Nature Methods · doi:10.1038/nmeth.1184 · Cited by 1,310 · see citing works
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works
A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria
Macpherson, A. J., Gatto, D., Sainsbury, E., Harriman, G. R., Hengartner, H., & Zinkernagel, R. M. (2000) · Science · doi:10.1126/science.288.5474.2222 · Cited by 1,113 · see citing works
Clustering of highly homologous sequences to reduce the size of large protein databases
Li, W.-Z., Jaroszewski, L., & Godzik, A. (2001) · Bioinform. · doi:10.1093/bioinformatics/17.3.282 · Cited by 1,021 · see citing works
Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
Garrett, W. S., Lord, G. M., Punit, S., Lugo‐Villarino, G., Mazmanian, S. K., Ito, S., Glickman, J. N., & Glimcher, L. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.017 · Cited by 918 · see citing works
Self-citationSwidsinski, A., Weber, J., Loening-Baucke, V., Hale, L. P., & Lochs, H. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.7.3380-3389.2005 · Cited by 894 · cited 3× · see citing works
“As has been reported in IBD patients using a universal bacterial 16S rRNA FISH probe (Swidsinski et al., 2005), we observed that the colonic mucus of colitic TRUC mice harbored numerous bacteria and that there was a consistent loss of a ‘‘bacterialfree zone’’ adjacent to the colonic epithelium (Figure 2E).”
MethodInfluentialIgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis
Peterson, D. A., McNulty, N. P., Guruge, J. L., & Gordon, J. I. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.013 · Cited by 828 · see citing works
Self-citationUse of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
Smith, K., McCoy, K. D., & Macpherson, A. J. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.10.002 · Cited by 789 · see citing works
Neurath, M. F., Weigmann, B., Finotto, S., Glickman, J. N., Nieuwenhuis, E. E. S., Iijima, H., Mizoguchi, A., Mizoguchi, E., Mudter, J., Galle, P. R., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011956 · Cited by 606 · see citing works
Self-citationThe Biology of Intestinal Immunoglobulin A Responses
Cerutti, A., & Rescigno, M. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.001 · Cited by 548 · see citing works
Regulatory Lymphocytes and Intestinal Inflammation
Ízcue, A., Coombes, J. L., & Powrie, F. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132657 · Cited by 505 · see citing works
Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases
Peterson, D. A., Frank, D. N., Pace, N. R., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.001 · Cited by 503 · see citing works
Self-citationLupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.08.002 · Cited by 501 · see citing works
probeBase--an online resource for rRNA-targeted oligonucleotide probes: new features 2007
Loy, A., Maixner, F., Wagner, M., & Horn, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl856 · Cited by 488 · see citing works
Hill, D. A., Hoffmann, C., Abt, M. C., Du, Y., Kobuley, D. E., Kirn, T. J., Bushman, F. D., & Artis, D. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.132 · Cited by 425 · see citing works
Immune Responses to the Microbiota at the Intestinal Mucosal Surface
Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424 · see citing works
Fluorescent In Situ Hybridization Allows Rapid Identification of Microorganisms in Blood Cultures
Kempf, V. A. J., Trebesius, K., & Autenrieth, I. B. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.2.830-838.2000 · Cited by 408 · see citing works
Gastrointestinal microbiology enters the metagenomics era
Frank, D. N., & Pace, N. R. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f2b0e8 · Cited by 405 · see citing works
Klebsiella oxytoca as a Causative Organism of Antibiotic-Associated Hemorrhagic Colitis
Högenauer, C., Langner, C., Beubler, E., Lippe, I. T., Schicho, R., Gorkiewicz, G., Krause, R., Gerstgrasser, N. W., Krejs, G. J., & Hinterleitner, T. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054765 · Cited by 349 · see citing works
Recognition of Host Immune Activation by Pseudomonas aeruginosa
Wu, L., Estrada, O., Zaborina, O. Y., Bains, M., Shen, L., Kohler, J. E., Patel, N. J., Musch, M. W., Chang, E. B., Fu, Y., et al. (2005) · Science · doi:10.1126/science.1112422 · Cited by 330 · see citing works
Wilson, E., & Butcher, E. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041069 · Cited by 229 · see citing works
Niess, J. H., & Adler, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901936 · Cited by 196 · see citing works
Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
Garrett, W. S., Punit, S., Gallini, C. A., Michaud, M., Zhang, D., Sigrist, K. S., Lord, G. M., Glickman, J. N., & Glimcher, L. H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.015 · Cited by 155 · see citing works
Self-citationHoffmann, C., Hill, D. A., Minkah, N., Kirn, T., Troy, A., Artis, D., & Bushman, F. (2009) · Infection and Immunity · doi:10.1128/iai.00493-09 · Cited by 142 · see citing works
The role of infection in the aetiology of inflammatory bowel disease
Hansen, R., Thomson, J., El-Omar, E. M., & Hold, G. L. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-009-0191-y · Cited by 120 · see citing works
Soluble Receptors and Cytokine Antagonists in Human Milk
Buescher, E. S., & Malinowska, I. (1996) · Pediatric Research · doi:10.1203/00006450-199612000-00011 · Cited by 106 · see citing works
Friedrich, U., Langenhove, H. V., Altendorf, K., et al. (2003) · Environmental Microbiology · doi:10.1046/j.1462-2920.2003.00397.x · Cited by 79 · see citing works
The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells
Lugo‐Villarino, G., Ito, S.-I., Klinman, D. M., & Glimcher, L. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506638102 · Cited by 60 · see citing works
Self-citationCooper, R., Fraser, S., Sturrock, R. D., et al. (1988) · BMJ · doi:10.1136/bmj.296.6634.1432 · Cited by 50 · see citing works
Host and microbiota factors that control Klebsiella pneumoniae mucosal colonization in mice
Lau, H. Y., Huffnagle, G. B., & Moore, T. A. (2008) · Microbes and Infection · doi:10.1016/j.micinf.2008.07.040 · Cited by 49 · see citing works
Tiwana, H., Walmsley, R. S., Wilson, C. R., et al. (1998) · Lara D. Veeken · doi:10.1093/rheumatology/37.5.525 · Cited by 35 · see citing works
Microbial–Host Interactions in Inflammatory Bowel Diseases and Experimental Colitis
Sartor, R. B. (2009) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000235787 · Cited by 31 · see citing works
Joint Extraintestinal Manifestations in Ulcerative Colitis
Dorofeyev, A. E., Василенко, И. В., & Rassokhina, O. A. (2009) · Digestive Diseases · doi:10.1159/000233289 · Cited by 30 · see citing works
Serological studies in Crohn's disease
Ibbotson, J. P., Pease, P., & Allan, R. N. (1987) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02017614 · Cited by 23 · see citing works
Proteus dysbioses in patients with ulcerative colitis
Kanareykina, S. K., Misautova, A. A., Zlatkina, A. R., et al. (1987) · Food / Nahrung · doi:10.1002/food.19870310570 · Cited by 13 · see citing works
Maintaining Diplomatic Relations Between Mammals and Beneficial Microbial Communities
Hill, D. A., & Artis, D. (2009) · Science Signaling · doi:10.1126/scisignal.298pe77 · Cited by 7 · see citing works
Romanova, Y. M., Scheglovitova, O. N., Boshnakov, R. H., et al. (2002) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Weiser MM Intestinal Epithelial Cell Surface Membrane Glycoprotein Synthesis: I. An Indicator of Cellular Differentiation Journal of Biochemistry 1973 248 2536 41 4698230
Cited by
Sorted by citations
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
Self-citationRole of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · see citing works
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Self-citationDysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713 · see citing works
Alterations of the human gut microbiome in liver cirrhosis
Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., et al. (2014) · Nature · doi:10.1038/nature13568 · Cited by 2,177 · see citing works
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works
The keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790 · see citing works
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699 · see citing works
Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689 · see citing works
Microbiota-mediated colonization resistance against intestinal pathogens
Buffie, C. G., & Pamer, E. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3535 · Cited by 1,564 · see citing works
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · see citing works
How glycan metabolism shapes the human gut microbiota
Koropatkin, N. M., Cameron, E. A., & Martens, E. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2746 · Cited by 1,419 · see citing works
Interactions between the microbiota and pathogenic bacteria in the gut
Bäumler, A. J., & Sperandio, V. (2016) · Nature · doi:10.1038/nature18849 · Cited by 1,420 · see citing works
The role of gut microbiota in immune homeostasis and autoimmunity
Wu, H.-J., & Wu, E. (2012) · Gut Microbes · doi:10.4161/gmic.19320 · Cited by 1,426 · see citing works
Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.006 · Cited by 1,154 · see citing works
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., Brown, J., Becker, C. A., Fleshner, P. R., Dubinsky, M., et al. (2012) · Science · doi:10.1126/science.1221789 · Cited by 1,073 · see citing works
Gupta, V. K., Paul, S., & Dutta, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01162 · Cited by 1,019 · see citing works
Host-Derived Nitrate Boosts Growth of <i>E. coli</i> in the Inflamed Gut
Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019 · see citing works
Atarashi, K., Suda, W., Luo, C., Kawaguchi, T., Motoo, I., Narushima, S., Kiguchi, Y., Yasuma, K., Watanabe, E., Tanoue, T., et al. (2017) · Science · doi:10.1126/science.aan4526 · Cited by 957 · see citing works
IBD—what role do Proteobacteria play?
Mukhopadhya, I., Hansen, R., El-Omar, E. M., & Hold, G. L. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.14 · Cited by 810 · see citing works
The microbiome in infectious disease and inflammation
Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works
Intestinal microbiota in human health and disease: the impact of probiotics
Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works
The composition of the gut microbiota shapes the colon mucus barrier
Jakobsson, H. E., Rodríguez‐Piñeiro, A. M., Schütte, A., Ermund, A., Boysen, P., Bemark, M., Sommer, F., Bäckhed, F., Hansson, G. C., & Johansson, M. E. (2015) · The EMBO Reports · doi:10.15252/embr.201439263 · Cited by 700 · see citing works
“The class Deltaproteobacteria contains sulphur-reducing bacteria (SRB) that are also found at higher frequencies in patients with IBD as compared to healthy individuals [41].”
InfluentialThe immune system and the gut microbiota: friends or foes?
Cerf-Bensussan, N., & Gaboriau-Routhiau, V. (2010) · Nature Reviews Immunology · doi:10.1038/nri2850 · Cited by 704 · see citing works
Tlaskalová-Hogenová, H., Štěpánková, R., Kozáková, H., Hudcovic, T., Vannucci, L., Tučková, L., Rossmann, P., Hrnčíř, T., Kverka, M., Zákostelská, Z., et al. (2011) · Cellular & Molecular Immunology · doi:10.1038/cmi.2010.67 · Cited by 693 · see citing works
Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction
Litvak, Y., Byndloss, M. X., Tsolis, R. M., & Bäumler, A. J. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.07.003 · Cited by 658 · see citing works
Polymicrobial synergy and dysbiosis in inflammatory disease
Lamont, R. J., & Hajishengallis, G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.11.004 · Cited by 585 · see citing works
The outer mucus layer hosts a distinct intestinal microbial niche
Li, H., Limenitakis, J. P., Fuhrer, T., Geuking, M. B., Lawson, M. A., Wyss, M., Brugiroux, S., Keller, I., Macpherson, J. A., Rupp, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9292 · Cited by 511 · see citing works
T-bet: a bridge between innate and adaptive immunity
Lazarevic, V., Glimcher, L. H., & Lord, G. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3536 · Cited by 486 · see citing works
Self-citationBloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.009 · Cited by 488 · see citing works
Iljazovic, A., Roy, U., Gálvez, E. J. C., Lesker, T. R., Zhao, B., Gronow, A., Amend, L., Will, S. E., Hofmann, J. D., Pils, M. C., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-0296-4 · Cited by 454 · see citing works
Schaubeck, M., Clavel, T., Calasan, J., Lagkouvardos, I., Haange, S. B., Jehmlich, N., Basic, M., Dupont, A., Hornef, M., Bergen, M. V., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309333 · Cited by 447 · see citing works
The microbiota regulate neuronal function and fear extinction learning
Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421 · see citing works
Complex host genetics influence the microbiome in inflammatory bowel disease
Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., et al. (2014) · Genome Medicine · doi:10.1186/s13073-014-0107-1 · Cited by 418 · see citing works
Horai, R., Zárate-Bladés, C. R., Dillenburg-Pilla, P., Chen, J., Kielczewski, J. L., Silver, P. B., Jittayasothorn, Y., Chan, C.-C., Yamane, H., Honda, K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.014 · Cited by 402 · see citing works
Arthur, J. C., Gharaibeh, R. Z., Mühlbauer, M., Perez-Chanona, E., Uronis, J. M., McCafferty, J., Fodor, A. A., & Jobin, C. (2014) · Nature Communications · doi:10.1038/ncomms5724 · Cited by 392 · see citing works
Hold, G. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1192 · Cited by 365 · see citing works
Inflammatory Bowel Disease as a Model for Translating the Microbiome
Huttenhower, C., Kostic, A. D., & Xavier, R. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.013 · Cited by 332 · see citing works
Seo, S.-U., Kamada, N., Muñoz-Planillo, R., Kim, Y.-G., Kim, D., Koizumi, Y., Hasegawa, M., Himpsl, S. D., Browne, H. P., Lawley, T. D., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.004 · Cited by 318 · see citing works
Role of the microbiota in inflammatory bowel diseases
Nagalingam, N. A., & Lynch, S. V. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21866 · Cited by 315 · see citing works
Immune-microbiota interactions in health and disease
Palm, N. W., de Zoete, M. R., & Flavell, R. A. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.05.014 · Cited by 315 · see citing works
Carroll, I. M., Ringel-Kulka, T., Keku, T. O., Chang, Y.-H., Packey, C. D., Sartor, R. B., & Ringel, Y. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2011 · Cited by 292 · see citing works
Hajishengallis, G., & Lamont, R. J. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.02.010 · Cited by 275 · see citing works
“The two organisms together induce colitis in specific-pathogen-free wild-type mice but not in germfree TRUC mice, suggesting that their colitogenicity requires the indigenous microbial community rather than a host with altered immune function [54].”
BackgroundInfluentialLópez, P., de Paz, B., Rodríguez-Carrio, J., Hevia, A., Sánchez, B., Margolles, A., & Suárez, A. (2016) · Scientific Reports · doi:10.1038/srep24072 · Cited by 262 · see citing works
Linking the Microbiota, Chronic Disease, and the Immune System
Hand, T. W., Vujkovic-Cvijin, I., Ridaura, V. K., & Belkaid, Y. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.08.003 · Cited by 247 · see citing works
Microbiota-mediated inflammation and antimicrobial defense in the intestine
Caballero, S., & Pamer, E. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120238 · Cited by 238 · see citing works
Frantz, A. L., Rogier, E. W., Weber, C. R., Shen, L., Cohen, D. A., Fenton, L. A., Bruno, M. E. C., & Kaetzel, C. S. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.23 · Cited by 230 · see citing works
Kim, M., Hwang, S., Park, E., & Bae, J. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12079 · Cited by 220 · see citing works
Intestinal Microbes in Inflammatory Bowel Diseases
Sartor, R. B., & Mazmanian, S. K. (2012) · The American Journal of Gastroenterology Supplements · doi:10.1038/ajgsup.2012.4 · Cited by 206 · see citing works
A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice
Caruso, R., Mathes, T., Martens, E. C., Kamada, N., Nusrat, A., Inohara, N., & Núñez, G. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw4341 · Cited by 185 · see citing works
Dysbiosis in the inflamed intestine: Chance favors the prepared microbe
Winter, S. E., & Bäumler, A. J. (2014) · Gut Microbes · doi:10.4161/gmic.27129 · Cited by 194 · see citing works
The intestinal microbiota in inflammatory bowel disease
Becker, C., Neurath, M. F., & Wirtz, S. (2015) · ILAR Journal · doi:10.1093/ilar/ilv030 · Cited by 185 · see citing works
Amir, I., Konikoff, F. M., Oppenheim, M., Gophna, U., & Half, E. E. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12285 · Cited by 176 · see citing works
Disruption of the gut ecosystem by antibiotics.
Yoon, M. Y., & Yoon, S. S. (2018) · Yonsei Medical Journal · doi:10.3349/ymj.2018.59.1.4 · Cited by 175 · see citing works
Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice
Choi, J. G., Kim, N., Ju, I. G., Eo, H., Lim, S.-M., Jang, S.-E., Kim, D.-H., & Oh, M. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19646-x · Cited by 170 · see citing works
Waclawiková, B., & El Aidy, S. (2018) · Pharmaceuticals · doi:10.3390/ph11030063 · Cited by 172 · see citing works
Fecal microbiota transplantation beyond Clostridioides difficile infections
Wortelboer, K., Nieuwdorp, M., & Herrema, H. (2019) · eBioMedicine · doi:10.1016/j.ebiom.2019.05.066 · Cited by 163 · see citing works
A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis
Di Gioia, D., Bozzi Cionci, N., Baffoni, L., Amoruso, A., Pane, M., Mogna, L., Gaggìa, F., Lucenti, M. A., Bersano, E., Cantello, R., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01607-9 · Cited by 151 · see citing works
Linking microbiota to human diseases: a systems biology perspective
Wu, H., Tremaroli, V., & Bäckhed, F. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.09.011 · Cited by 150 · see citing works
Host-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases
Grigg, J. B., & Sonnenberg, G. F. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601621 · Cited by 130 · see citing works
Gut microbiome and anticancer immune response: really hot Sh*t!
Viaud, S., Daillère, R., Boneca, I. G., Lepage, P., Langella, P., Chamaillard, M., Pittet, M. J., Ghiringhelli, F., Trinchieri, G., Goldszmid, R., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.56 · Cited by 123 · see citing works
Mining the human gut microbiota for effector strains that shape the immune system
Ahern, P. P., Faith, J. J., & Gordon, J. I. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.012 · Cited by 123 · see citing works
Arthur, J. C., Gharaibeh, R. Z., Uronis, J. M., Perez-Chanona, E., Sha, W., Tomkovich, S., Mühlbauer, M., Fodor, A. A., & Jobin, C. (2013) · Scientific Reports · doi:10.1038/srep02868 · Cited by 118 · see citing works
Impact of a 3-Months Vegetarian Diet on the Gut Microbiota and Immune Repertoire
Zhang, C., Björkman, A., Cai, K., Liu, G., Wang, C., Li, Y., Xia, H., Sun, L., Kristiansen, K., Wang, J., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00908 · Cited by 87 · see citing works
Lyte, M., Chapel, A., Lyte, J. M., Ai, Y., Proctor, A., Jane, J.-L., & Phillips, G. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146406 · Cited by 62 · see citing works
- Authors
- Garrett, W. S., Gallini, C. A., Yatsunenko, T., Michaud, M., DuBois, A., Delaney, M. L., Punit, S., Karlsson, M., Bry, L., Glickman, J. N., Gordon, J. I., Onderdonk, A. B., & Glimcher, L. H.
- Affiliations
- Harvard University (US)
- Washington University in St. Louis (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Garrett, Wendy S.
- Glimcher, Laurie H.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 8
- Issue
- 3
- Pages
- 292-300
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC2952357
- OpenAlex
- W2020913417
- Cited by
- 788
- References
- 46
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 48 · 2023: 43 · 2022: 55 · 2021: 48 · 2020: 56 · 2019: 50 · 2018: 49 · 2017: 53 · 2016: 51 · 2015: 54 · 2014: 60 · 2013: 62 · 2012: 65
- FWCI
- 23.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Crohn's and Colitis Foundation
- National Cancer Institute (R01CA112663, CA112663, T32CA009172)
- National Institute of Allergy and Infectious Diseases (K08AI078942)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK03485)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- Enterobacteriaceae, gut microbiota, inflammatory bowel disease, ulcerative colitis, Rag2 knockout mice, Klebsiella pneumoniae, Proteus mirabilis, cross-fostering, innate immunity
- MeSH terms
- Animals, Colitis, Ulcerative, Colon, Dendritic Cells, Disease Models, Animal, DNA-Binding Proteins, Enterobacteriaceae, Feces, Female, Intestinal Mucosa, Intestines, Klebsiella pneumoniae, Male, Proteus mirabilis, In Situ Hybridization, Fluorescence, Disease Progression, T-Box Domain Proteins, Mice, Microbial Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
