The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT
Abstract
Noncoding RNA molecules (ncRNAs) have been implicated in numerous biological processes including transcriptional regulation and the modulation of protein function. Yet, in spite of the apparent abundance of ncRNA, little is known about the biological role of the projected thousands of ncRNA genes present in the human genome. To facilitate functional analysis of these RNAs, we have created an arrayed library of short hairpin RNAs (shRNAs) directed against 512 evolutionarily conserved putative ncRNAs and, via cell-based assays, we have begun to determine their roles in cellular pathways. Using this system, we have identified an ncRNA repressor of the nuclear factor of activated T cells (NFAT), which interacts with multiple proteins including members of the importin-beta superfamily and likely functions as a specific regulator of NFAT nuclear trafficking.
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Cites
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Cited by
Long non-coding RNAs: insights into functions
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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“(1) Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge MA 02142 (2) Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139 (3) Department of Pathology, Beth Israel Deaconess Medical Center, Boston MA 02215 (4) Division of Health Sciences and Technology, Massachusetts Institute…”
Evolution and Functions of Long Noncoding RNAs
Ponting, C. P., Oliver, P. L., & Reik, W. (2009) · Cell · doi:10.1016/j.cell.2009.02.006 · Cited by 4,208
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lincRNAs: Genomics, Evolution, and Mechanisms
Ulitsky, I., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.06.020 · Cited by 2,608
Metadata
- Authors
- Willingham, A. T., Orth, A. P., Batalov, S., Peters, E. C., Wen, B. G., Aza-Blanc, P., Hogenesch, J. B., & Schultz, P. G.
- Venue
- Science
- Published
- 2005-09-02
- Volume
- 309
- Issue
- 5740
- Pages
- 1570-1573
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2166967514
- Cited by
- 729
- References
- 23
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Willingham, A. T., Orth, A. P., Batalov, S., Peters, E. C., Wen, B. G., Aza-Blanc, P., Hogenesch, J. B., & Schultz, P. G. (2005). A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT. Science. https://doi.org/10.1126/science.1115901
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