The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
The Functional Genomics of Noncoding RNA
Abstract
Large numbers of noncoding RNA transcripts (ncRNAs) are being revealed by complementary DNA cloning and genome tiling array studies in animals. The big and as yet largely unanswered question is whether these transcripts are relevant. A paper by Willingham et al . shows the way forward by developing a strategy for large-scale functional screening of ncRNAs, involving small interfering RNA knockdowns in cell-based screens, which identified a previously unidentified ncRNA repressor of the transcription factor NFAT. It appears likely that ncRNAs constitute a critical hidden layer of gene regulation in complex organisms, the understanding of which requires new approaches in functional genomics.
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Cites
The Transcriptional Landscape of the Mammalian Genome
Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M. C., Maeda, N., Oyama, R., Ravasi, T., Lenhard, B., Wells, C., et al. (2005) · Science · doi:10.1126/science.1112014 · Cited by 3,499
Self-citationIdentification of hundreds of conserved and nonconserved human microRNAs
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Antisense Transcription in the Mammalian Transcriptome
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Self-citationAnalysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team* (2002) · Nature · doi:10.1038/nature01266 · Cited by 1,642
Ribo-gnome: The Big World of Small RNAs
Zamore, P. D., & Haley, B. (2005) · Science · doi:10.1126/science.1111444 · Cited by 1,288
Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution
Cheng, J., Kapranov, P., Drenkow, J., Dike, S., Brubaker, S., Patel, S., Long, J., Stern, D., Tammana, H., Helt, G., et al. (2005) · Science · doi:10.1126/science.1108625 · Cited by 1,178
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Global Identification of Human Transcribed Sequences with Genome Tiling Arrays
Bertone, P., Stolc, V., Royce, T. E., Rozowsky, J. S., Urban, A. E., Zhu, X., Rinn, J. L., Tongprasit, W., Samanta, M., Weissman, S., et al. (2004) · Science · doi:10.1126/science.1103388 · Cited by 1,014
RNA regulation: A new genetics?
Mattick, J. S. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1321 · Cited by 765
Self-citationA microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans
Johnston, R. J., & Hobert, O. (2003) · Nature · doi:10.1038/nature02255 · Cited by 759
Cited by
Kino, T., Hurt, D. E., Ichijo, T., Nader, N., & Chrousos, G. P. (2010) · Science Signaling · doi:10.1126/scisignal.2000568 · Cited by 1,231
Epigenetics and gene expression
Gibney, E. R., & Nolan, C. M. (2010) · Heredity · doi:10.1038/hdy.2010.54 · Cited by 1,109
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Gerstein, M. B., Lu, Z. J., Van Nostrand, E. L., Cheng, C., Arshinoff, B. I., Liu, T., Yip, K. Y., Robilotto, R., Rechtsteiner, A., Ikegami, K., et al. (2010) · Science · doi:10.1126/science.1196914 · Cited by 955
Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function
Pang, K. C., Frith, M. C., & Mattick, J. S. (2006) · Trends in Genetics · doi:10.1016/j.tig.2005.10.003 · Cited by 656
Self-citationTargeting long non-coding RNA to therapeutically upregulate gene expression
Wahlestedt, C. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4018 · Cited by 532
Metadata
- Authors
- Mattick, J. S.
- Venue
- Science
- Published
- 2005-09-02
- Volume
- 309
- Issue
- 5740
- Pages
- 1527-1528
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002124496
- Cited by
- 297
- References
- 21
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
