The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Increase in Activity During Calorie Restriction Requires Sirt1
Abstract
Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide‐dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
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“Homologues of Sir2 (called sirtuins) have subsequently been shown to mediate some of the effects of caloric restriction in flies (82) and mammals (83,84).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [84]
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Cites
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Self-citationThe retardation of aging and disease by dietary restriction
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Sir2 mediates longevity in the fly through a pathway related to calorie restriction
Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361
Activity Measures in Rhesus Monkeys on Long-Term Calorie Restriction
Weed, J. L., Lane, M. A., Roth, G. S., Speer, D. L., & Ingram, D. K. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00147-9 · Cited by 117
Interaction between exercise and food restriction: effects on longevity of male rats
Holloszy, J. O., & Schechtman, K. B. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.4.1529 · Cited by 101
Growth hormone treatment in aging: state of the art and perspectives
Giustina, A., Desenzani, P., Bossoni, S., & Perini, P. (1997) · Aging Clinical and Experimental Research · doi:10.1007/bf03339716 · Cited by 7
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Research works printed but not linked: 1
- R. J. McCarteret al., Aging (Milano)9, 73 (1997).
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Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602
Neural mechanisms of ageing and cognitive decline
Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310
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Metadata
- Authors
- Chen, D., Steele, A. D., Lindquist, S., & Guarente, L.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Guarente, Leonard
- Venue
- Science
- Published
- 2005-12-09
- Volume
- 310
- Issue
- 5754
- Pages
- 1641-1641
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2156934560
- Cited by
- 419
- References
- 6
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 7 · 2019: 9 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 17 · 2014: 20 · 2013: 28 · 2012: 29
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG11119)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- SIRT1, Sir2, caloric restriction, longevity, metabolic activity, mice
- MeSH terms
- Animals, Eating, Motor Activity, Movement, Mice, Knockout, Caloric Restriction, Sirtuins, Mice, Sirtuin 1
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