The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
A Thiolate-Ligated Nonheme Oxoiron(IV) Complex Relevant to Cytochrome P450
Abstract
Thiolate-ligated oxoiron(IV) centers are postulated to be the key oxidants in the catalytic cycles of oxygen-activating cytochrome P450 and related enzymes. Despite considerable synthetic efforts, chemists have not succeeded in preparing an appropriate model complex. Here we report the synthesis and spectroscopic characterization of [Fe IV (O)(TMCS)] + where TMCS is a pentadentate ligand that provides a square pyramidal N 4 (SR) apical , where SR is thiolate, ligand environment about the iron center, which is similar to that of cytochrome P450. The rigidity of the ligand framework stabilizes the thiolate in an oxidizing environment. Reactivity studies suggest that thiolate coordination favors hydrogen-atom abstraction chemistry over oxygen-atom transfer pathways in the presence of reducing substrates.
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Cites
Cytochrome P-450: Structure, Mechanism, and Biochemistry
de Montellano, O., & Paul, R. (1986) · Medical Entomology and Zoology · Cited by 2,663
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Self-citationMechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
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A Multiplet Analysis of Fe K-Edge 1s → 3d Pre-Edge Features of Iron Complexes
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The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution
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Mammalian nitric oxide synthases
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Crystallographic and Spectroscopic Characterization of a Nonheme Fe(IV)=O Complex
Rohde, J.-U., In, J.-H., Lim, M. H., Brennessel, W. W., Bukowski, M. R., Stubna, A., Münck, E., Nam, W., & Que, L. (2003) · Science · doi:10.1126/science.299.5609.1037 · Cited by 929
Self-citationNonheme FeIVO Complexes That Can Oxidize the C−H Bonds of Cyclohexane at Room Temperature
Kaizer, J., Klinker, E. J., Oh, N. Y., Rohde, J.-U., Song, W. J., Stubna, A., Kim, J., Münck, E., Nam, W., & Que, L. (2004) · Journal of the American Chemical Society · doi:10.1021/ja037288n · Cited by 647
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Cited by
Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins
Huang, X., & Groves, J. T. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00373 · Cited by 1,037
Reactivity of High-Valent Iron–Oxo Species in Enzymes and Synthetic Reagents: A Tale of Many States
Shaik, S., Hirao, H., & Kumar, D. (2007) · Accounts of Chemical Research · doi:10.1021/ar600042c · Cited by 555
Axial ligand tuning of a nonheme iron(IV)–oxo unit for hydrogen atom abstraction
Sastri, C. V., Lee, J., Oh, K., Lee, Y. J., Lee, J., Jackson, T. A., Ray, K., Hirao, H., Shin, W., Halfen, J. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709471104 · Cited by 411
Self-citationGuo, M., Corona, T., Ray, K., & Nam, W. (2019) · ACS Central Science · doi:10.1021/acscentsci.8b00698 · Cited by 401
Self-citationSlow Magnetic Relaxation in a Family of Trigonal Pyramidal Iron(II) Pyrrolide Complexes
Harman, W. H., Harris, T. D., Freedman, D. E., Fong, H., Chang, A., Rinehart, J. D., Ozarowski, A., Sougrati, M. T., Grandjean, F., Long, G. J., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105291x · Cited by 342
Metadata
- Authors
- Bukowski, M. R., Koehntop, K. D., Stubna, A., Bominaar, E. L., Halfen, J. A., Münck, E., Nam, W., & Que, L.
- Venue
- Science
- Published
- 2005-11-11
- Volume
- 310
- Issue
- 5750
- Pages
- 1000-1002
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982018391
- Cited by
- 267
- References
- 22
- FWCI
- 16.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bukowski, M. R., Koehntop, K. D., Stubna, A., Bominaar, E. L., Halfen, J. A., Münck, E., Nam, W., & Que, L. (2005). A Thiolate-Ligated Nonheme Oxoiron(IV) Complex Relevant to Cytochrome P450. Science. https://doi.org/10.1126/science.1119092
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