The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate
Abstract
Instead of the immunoglobulin-type antigen receptors of jawed vertebrates, jawless fish have variable lymphocyte receptors (VLRs), which consist of leucine-rich repeat (LRR) modules. Somatic diversification of the VLR gene is shown here to occur through a multistep assembly of LRR modules randomly selected from a large bank of flanking cassettes. The predicted concave surface of the VLR is lined with hypervariable positively selected residues, and computational analysis suggests a repertoire of about 10 14 unique receptors. Lamprey immunized with anthrax spores responded with the production of soluble antigen-specific VLRs. These findings reveal that two strikingly different modes of antigen recognition through rearranged lymphocyte receptors have evolved in the jawless and jawed vertebrates.
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Cites
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
Traver, D., Paw, B. H., Poss, K. D., Penberthy, W. T., Lin, S., & Zon, L. I. (2003) · Nature Immunology · doi:10.1038/ni1007 · Cited by 800
Schubert, W.-D., Urbanke, C., Ziehm, T., Beier, V., Machner, M. P., Domann, E., Wehland, J., Chakraborty, T., & Heinz, D. W. (2002) · Cell · doi:10.1016/s0092-8674(02)01136-4 · Cited by 302
Cited by
Makarova, K. S., Grishin, N. V., Shabalina, S. A., Wolf, Y. I., & Koonin, E. V. (2006) · Biology Direct · doi:10.1186/1745-6150-1-7 · Cited by 1,199
The Evolution of Adaptive Immune Systems
Cooper, M. D., & Alder, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.02.001 · Cited by 873
Self-citationThe immune gene repertoire encoded in the purple sea urchin genome
Hibino, T., Loza-Coll, M., Messier, C., Majeske, A. J., Cohen, A. H., Terwilliger, D. P., Buckley, K. M., Brockton, V., Nair, S. V., Berney, K., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.065 · Cited by 630
Self-citationDual nature of the adaptive immune system in lampreys
Guo, P., Hirano, M., Herrin, B. R., Li, J., Yu, C., Sadlonova, A., & Cooper, M. D. (2009) · Nature · doi:10.1038/nature08068 · Cited by 336
Self-citationBoehm, T., McCurley, N., Sutoh, Y., Schorpp, M., Kasahara, M., & Cooper, M. D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075038 · Cited by 239
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Metadata
- Authors
- Alder, M. N., Rogozin, I. B., Iyer, L. M., Glazko, G. V., Cooper, M. D., & Pancer, Z.
- Venue
- Science
- Published
- 2005-12-23
- Volume
- 310
- Issue
- 5756
- Pages
- 1970-1973
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067073663
- Cited by
- 321
- References
- 2
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
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