The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A Systems Approach to Mapping DNA Damage Response Pathways
Open accessAbstract
Failure of cells to respond to DNA damage is a primary event associated with mutagenesis and environmental toxicity. To map the transcriptional network controlling the damage response, we measured genomewide binding locations for 30 damage-related transcription factors (TFs) after exposure of yeast to methyl-methanesulfonate (MMS). The resulting 5272 TF-target interactions revealed extensive changes in the pattern of promoter binding and identified damage-specific binding motifs. As systematic functional validation, we identified interactions for which the target changed expression in wild-type cells in response to MMS but was nonresponsive in cells lacking the TF. Validated interactions were assembled into causal pathway models that provide global hypotheses of how signaling, transcription, and phenotype are integrated after damage.
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Cites
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., & Brown, P. O. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4241 · Cited by 4,815
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science · doi:10.1126/science.1075090 · Cited by 2,956
Self-citationGasch, A. P., Huang, M., Metzner, S., Botstein, D., Elledge, S. J., & Brown, P. O. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.2987 · Cited by 542
Global response of Saccharomyces cerevisiae to an alkylating agent
Jelinsky, S. A., & Samson, L. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1486 · Cited by 419
Self-citationJelinsky, S. A., Estep, P., Church, G. M., & Samson, L. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8157-8167.2000 · Cited by 335
Self-citationJia, Y., Rothermel, B., Thornton, J., & Butow, R. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1110 · Cited by 219
Cited by
Ideker, T., & Sharan, R. (2008) · Genome Research · doi:10.1101/gr.071852.107 · Cited by 817
Self-citationA systems approach to measuring the binding energy landscapes of transcription factors.
Maerkl, S. J., & Quake, S. R. (2007) · Science · doi:10.1126/science.1131007 · Cited by 584
Integrative approaches for finding modular structure in biological networks
Mitra, K., Carvunis, A.-R., Ramesh, S. K., & Ideker, T. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3552 · Cited by 535
Self-citationUnbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses
Amit, I., Garber, M., Chevrier, N., Leite, A. P., Donner, Y., Eisenhaure, T., Guttman, M., Grenier, J. K., Li, W., Zuk, O., et al. (2009) · Science · doi:10.1126/science.1179050 · Cited by 488
High-resolution DNA-binding specificity analysis of yeast transcription factors
Zhu, C., Byers, K. J. R. P., McCord, R. P., Shi, Z., Berger, M. F., Newburger, D. E., Saulrieta, K., Smith, Z., Shah, M. V., Radhakrishnan, M., et al. (2009) · Genome Research · doi:10.1101/gr.090233.108 · Cited by 398
Metadata
- Authors
- Workman, C. T., Mak, H. C., McCuine, S., Tagne, J.-B., Agarwal, M., Ozier, O., Begley, T. J., Samson, L. D., & Ideker, T.
- Venue
- Science
- Published
- 2006-05-19
- Volume
- 312
- Issue
- 5776
- Pages
- 1054-1059
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077953882
- Cited by
- 268
- References
- 7
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Workman, C. T., Mak, H. C., McCuine, S., Tagne, J.-B., Agarwal, M., Ozier, O., Begley, T. J., Samson, L. D., & Ideker, T. (2006). A Systems Approach to Mapping DNA Damage Response Pathways. Science. https://doi.org/10.1126/science.1122088
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
