Auxiliary Subunits Assist AMPA-Type Glutamate Receptors
Abstract
Glutamate, the major excitatory neurotransmitter in the brain, acts primarily on two types of ionotropic receptors: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and N-methyl-d-aspartate (NMDA) receptors. Work over the past decade indicates that regulated changes in the number of synaptic AMPA receptors may serve as a mechanism for information storage. Recent studies demonstrate that a family of small transmembrane AMPA receptor regulatory proteins (TARPs) controls both AMPA receptor trafficking and channel gating. TARPs provide the first example of auxiliary subunits of ionotropic receptors. Here we review the pivotal role that TARPs play in the life cycle of AMPA receptors.
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TARP family members contain a cytoplasmic CTD with closely spaced serines embedded within an arginine-rich region.
“All members of the family contain a cytoplasmic CTD that contains numerous closely spaced serines embedded within an arginine-rich (Arg-rich) region.”
From Synaptic memory and CaMKII (2023) · cites this paper as [282]
Enhanced RalBP1 binding to PSD-95 may bring RalBP1-associated endocytic proteins such as AP2 and POB1 close to PSD-95, which is linked to the complex of TARPs and AMPARs.
“Therefore, enhanced RalBP1 binding to PSD-95 may bring RalBP1-associated endocytic proteins such as AP2 and POB1 close to PSD-95, which is linked to the complex of TARPs and AMPARs [18].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [18]
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- Authors
- Nicoll, R. A., Tomita, S., & Bredt, D. S.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Nicoll, Roger A.
- Tomita, Susumu
- Bredt, David S.
- Venue
- Science
- Published
- 2006-03-03
- Volume
- 311
- Issue
- 5765
- Pages
- 1253-1256
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075621633
- Cited by
- 390
- References
- 6
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 10 · 2021: 17 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 18 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 18 · 2012: 17
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- AMPA receptors, auxiliary subunits, transmembrane AMPA receptor regulatory proteins, TARP, ionotropic glutamate receptors, receptor trafficking, channel gating, synaptic plasticity, information storage, NMDA receptor
- MeSH terms
- Animals, Brain, Hippocampus, Models, Biological, Synaptic Transmission, Neuronal Plasticity, Neurons, Phosphorylation, Protein Binding, Synapses, Calcium Channels, Ion Channel Gating, Receptors, AMPA, Protein Transport, Mice
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