The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Platelet-Derived Serotonin Mediates Liver Regeneration
Open accessAbstract
The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.
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Cites
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
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Self-citationLiver regeneration: from myth to mechanism
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Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
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A unique central tryptophan hydroxylase isoform
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Self-citationThe Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation
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Cited by
The expanded biology of serotonin
Berger, M., Gray, J. A., & Roth, B. L. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.042307.110802 · Cited by 2,100
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
Iredale, J. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30542 · Cited by 866
Liver Regeneration after Partial Hepatectomy
Michalopoulos, G. K. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090675 · Cited by 713
Metadata
- Authors
- Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., Gachet, C., Bader, M., & Clavien, P.-A.
- Venue
- Science
- Published
- 2006-04-07
- Volume
- 312
- Issue
- 5770
- Pages
- 104-107
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007486557
- Cited by
- 788
- References
- 30
- FWCI
- 27.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., Gachet, C., Bader, M., & Clavien, P.-A. (2006). Platelet-Derived Serotonin Mediates Liver Regeneration. Science. https://doi.org/10.1126/science.1123842
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
