The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A Role for the Macaque Anterior Cingulate Gyrus in Social Valuation
Abstract
Complex human social interaction is disrupted when the frontal lobe is damaged in disease, and in extreme cases patients are described as having acquired sociopathy. We compared, in macaques, the effects of lesions in subdivisions of the anterior cingulate and the orbitofrontal cortices believed to be anatomically homologous to those damaged in such patients. We show that the anterior cingulate gyrus in male macaques is critical for normal patterns of social interest in other individual male or female macaques. Conversely, the orbitofrontal cortex lesion had a marked effect only on responses to mildly fear-inducing stimuli. These results suggest that damage to the anterior cingulate gyrus may be the cause of changes in social interaction seen after frontal lobe damage.
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“Other anterior cingulate lesions around the genu reduced responsiveness to social cues, implying that this region helps evaluate such stimuli (Rudebeck et al., 2006).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Rudebeck et al., 2006
In the citing paper
“Other anterior cingulate lesions around the genu reduced responsiveness to social cues, implying that this region helps evaluate such stimuli (Rudebeck et al., 2006).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Rudebeck et al., 2006
In the citing paper
“Prior investigations in rodents and primates, for example, have provided evidence for the presence of neurons that encode information about other individuals, demonstrating changes in activity when the animals observe another’s appetitive or aversive experiences 1–11.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [1]
In the citing paper
“Here, we used microelectrode arrays that were implanted in the animal’s mPFC (Extended Data Fig. 1b), an area suggested to be involved in social behavior 1,7,12,26,34 and disorders such as ASD 14,21,35,36.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [1]
In the citing paper
“Previous investigations have provided insight into how discrete aspects of another animal’s experience, such as receipt of reward, may be encoded by cells 1–7,9.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [1]
Citations
Cites
Deep Brain Stimulation for Treatment-Resistant Depression
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Empathy for Pain Involves the Affective but not Sensory Components of Pain
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Neurons in the orbitofrontal cortex encode economic value
Padoa-Schioppa, C., & Assad, J. A. (2006) · Nature · doi:10.1038/nature04676 · Cited by 1,598
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Optimal decision making and the anterior cingulate cortex
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Research works printed but not linked: 2
- G. W. Van Hoesen, R. J. Morecraft, B. A. Vogt, in Neurobiology of Cingulate Cortex and Limbic Thalamus, B. A. Vogt, M. Gabriel, Eds. (Birkhauser, Boston, 1993), pp. 249–284.
- S. Mineka, in Theoretical Foundations of Behaviour Therapy, H. J. Eysenck, I. Martin, Eds. (Plenum, New York, 1987), pp. 81–111.
Cited by
Sorted by citations
The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082
Toward a second-person neuroscience
Schilbach, L., Timmermans, B., Reddy, V., Costall, A., Bente, G., Schlicht, T., & Vogeley, K. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12000660 · Cited by 1,510
When fear is near: threat imminence elicits prefrontal periaqueductal gray shifts in humans.
Mobbs, D., Petrovic, P., Marchant, J. L., Hassabis, D., Weiskopf, N., Seymour, B., Dolan, R. J., & Frith, C. D. (2007) · Science · doi:10.1126/science.1144298 · Cited by 951
Associative learning of social value
Behrens, T. E. J., Hunt, L. T., Woolrich, M. W., & Rushworth, M. F. S. (2008) · Nature · doi:10.1038/nature07538 · Cited by 925
Self-citationChoice, uncertainty and value in prefrontal and cingulate cortex
Rushworth, M. F. S., & Behrens, T. E. J. (2008) · Nature Neuroscience · doi:10.1038/nn2066 · Cited by 866
Self-citation
Metadata
- Authors
- Rudebeck, P. H., Buckley, M. J., Walton, M. E., & Rushworth, M. F. S.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Rudebeck, P. H.
- Venue
- Science
- Published
- 2006-09
- Volume
- 313
- Issue
- 5791
- Pages
- 1310-1312
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969866816
- Cited by
- 312
- References
- 27
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 28 · 2020: 15 · 2019: 11 · 2018: 17 · 2017: 20 · 2016: 18 · 2015: 15 · 2014: 12 · 2013: 22 · 2012: 20
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anterior cingulate cortex, orbitofrontal cortex, social valuation, social interest, frontal lobe lesions, macaque, fear response, social behavior
- MeSH terms
- Analysis of Variance, Animals, Fear, Female, Frontal Lobe, Gyrus Cinguli, Macaca, Male, Reaction Time, Social Behavior, Social Perception
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