Cited by 329Lipid Membrane Structure and BehaviorCellular transport and secretionPhagocytosis and Immune Regulation

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Receptor Activation Alters Inner Surface Potential During Phagocytosis

Yeung, Tony, Terebiznik, Mauricio, Yu, Liming, Silvius, John, Abidi, Wasif M., Philips, Mark, Levine, Tim, Kapus, Andras, Grinstein, Sergio·2006·Science

DOI 10.1126/science.1129551

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Abstract

The surface potential of biological membranes varies according to their lipid composition. We devised genetically encoded probes to assess surface potential in intact cells. These probes revealed marked, localized alterations in the charge of the inner surface of the plasma membrane of macrophages during the course of phagocytosis. Hydrolysis of phosphoinositides and displacement of phosphatidylserine accounted for the change in surface potential at the phagosomal cup. Signaling molecules such as K-Ras, Rac1, and c-Src that are targeted to the membrane by electrostatic interactions were rapidly released from membrane subdomains where the surface charge was altered by lipid remodeling during phagocytosis.

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Authors: Yeung, T., Terebiznik, M., Yu, L., Silvius, J., Abidi, W. M., Philips, M., Levine, T., Kapus, A., & Grinstein, S.
Affiliations: University of Toronto (CA)
Division of Cell Biology, Hepatology, and Nutrition Department, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Corresponding author: Grinstein, Sergio
ORCID: Yeung, Tony
Terebiznik, Mauricio
Silvius, John
Abidi, Wasif M.
Philips, Mark
Levine, Tim
Grinstein, Sergio
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2006-07-21
Volume: 313
Issue: 5785
Pages: 347-351
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1129551
OpenAlex: W1999972891
Cited by: 329
References: 9
Citations by year: 2026: 4 · 2025: 10 · 2024: 16 · 2023: 15 · 2022: 10 · 2021: 15 · 2020: 17 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 15 · 2014: 13 · 2013: 17 · 2012: 22
FWCI: 10.59
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: membrane surface potential, phagocytosis, macrophages, plasma membrane, phosphoinositide hydrolysis, phosphatidylserine exposure, lipid remodeling, genetically encoded probes, KRAS, Rac1, Src kinase, lipid rafts, receptor activation
MeSH terms: Animals, Calcium, Cell Line, Cell Membrane, Fluorescent Dyes, Immunoglobulin G, Lipid Bilayers, Liposomes, Macrophages, Membrane Potentials, Neuropeptides, Opsonin Proteins, Peptides, Phagocytosis, Phagosomes, Phospholipids, Receptors, Fc, Molecular Probes, Ionomycin, ras Proteins, rac GTP-Binding Proteins, rac1 GTP-Binding Protein, Mice, Static Electricity, Hydrophobic and Hydrophilic Interactions

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Receptor Activation Alters Inner Surface Potential During Phagocytosis

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