Cited by 267Neuroscience and Neuropharmacology ResearchIon channel regulation and functionPI3K/AKT/mTOR signaling in cancer

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Activity- and mTOR-Dependent Suppression of Kv1.1 Channel mRNA Translation in Dendrites

Raab-Graham, Kimberly F., Haddick, Patrick C. G., Jan, Yuh Nung, Jan, Lily Yeh·2006·Science

DOI 10.1126/science.1131693

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Abstract

Mammalian target of rapamycin (mTOR) is implicated in synaptic plasticity and local translation in dendrites. We found that the mTOR inhibitor, rapamycin, increased the Kv1.1 voltage-gated potassium channel protein in hippocampal neurons and promoted Kv1.1 surface expression on dendrites without altering its axonal expression. Moreover, endogenous Kv1.1 mRNA was detected in dendrites. Using Kv1.1 fused to the photoconvertible fluorescence protein Kaede as a reporter for local synthesis, we observed Kv1.1 synthesis in dendrites upon inhibition of mTOR or the N-methyl-d-aspartate (NMDA) glutamate receptor. Thus, synaptic excitation may cause local suppression of dendritic Kv1 channels by reducing their local synthesis.

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Authors: Raab-Graham, K. F., Haddick, P. C. G., Jan, Y. N., & Jan, L. Y.
Affiliations: Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94158, USA.
Howard Hughes Medical Institute (US)
Corresponding author: Haddick, Patrick C. G.
Jan, Lily Yeh
ORCID: Jan, Yuh Nung
Jan, Lily Yeh
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2006-10-06
Volume: 314
Issue: 5796
Pages: 144-148
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1131693
OpenAlex: W2028230396
Cited by: 267
References: 28
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 5 · 2020: 23 · 2019: 13 · 2018: 9 · 2017: 15 · 2016: 15 · 2015: 18 · 2014: 17 · 2013: 25 · 2012: 21
FWCI: 5.06
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1f32mh013010-01)
National Institute of Mental Health (MH13010, MH65334)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: Kv1.1, voltage-gated potassium channels, mTOR, local translation, dendrites, hippocampal neurons, rapamycin, NMDA receptor, synaptic plasticity, mRNA translation, channel surface expression, synaptic excitation
MeSH terms: Animals, Cells, Cultured, Dendrites, Hippocampus, Neuronal Plasticity, Neurons, Phosphorylation, Protein Kinases, Recombinant Fusion Proteins, RNA, Messenger, Sindbis Virus, Synapses, Protein Biosynthesis, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Sirolimus, Oligonucleotide Array Sequence Analysis, 3' Untranslated Regions, Protein Kinase Inhibitors, Rats, Kv1.1 Potassium Channel, TOR Serine-Threonine Kinases, In Vitro Techniques

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Activity- and mTOR-Dependent Suppression of Kv1.1 Channel mRNA Translation in Dendrites

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