The contribution of ion channels in input-output plasticity
Open accessAbstract
Persistent changes that occur in brain circuits are classically thought to be mediated by long-term modifications in synaptic efficacy. Yet, many studies have shown that voltage-gated ion channels located at the input and output side of the neurons are also the subject to persistent modifications. These channels are thus responsible for intrinsic plasticity that is expressed in many different neuronal types including glutamatergic principal neurons and GABAergic interneurons. As for synaptic plasticity, activation of synaptic glutamate receptors initiate persistent modification in neuronal excitability. We review here how synaptic input can be efficiently altered by activity-dependent modulation of ion channels that control EPSP amplification, spike threshold or resting membrane potential. We discuss the nature of the learning rules shared by intrinsic and synaptic plasticity, the mechanisms of ion channel regulation and the impact of intrinsic plasticity on induction of synaptic modifications.
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Chronic stress induces cell-type-specific shifts in intrinsic excitability within medial prefrontal and hippocampal neurons, biasing circuits toward vulnerability or resilience depending on channel composition and neuromodulatory state.
“Chronic stress induces cell-type-specific shifts in intrinsic excitability within medial prefrontal and hippocampal neurons, biasing circuits toward vulnerability or resilience depending on channel composition and neuromodulatory state [25,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [25]
The sections on homeostatic plasticity and GABAergic interneurons describe cell-type-dependent changes in intrinsic excitability involving ion channels, including in hippocampal neurons. They discuss activity deprivation and synaptic stimulation, not chronic stress; the passages do not establish shifts in medial prefrontal neurons or a resulting bias toward vulnerability or resilience. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIntrinsic excitability regulates neuronal gain and input-output transformations at the single cell level, unlike synaptic plasticity which modifies connection efficacy.
“Unlike synaptic plasticity, which modifies the efficacy of connections between neurons, intrinsic excitability regulates neuronal gain and input–output transformations at the single cell level [24,25,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [25]
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Shim, H. G., Jang, S.-S., Jang, D. C., Jin, Y., Chang, W. S., Park, J. M., & Kim, S. J. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00566.2015 · Cited by 18 · see citing works
Dasgupta, D., & Sikdar, S. K. (2014) · Hippocampus · doi:10.1002/hipo.22371 · Cited by 9 · see citing works
Dasgupta, D., & Sikdar, S. K. (2019) · Brain Research · doi:10.1016/j.brainres.2019.02.013 · Cited by 5 · see citing works
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Rátkai, A., Tárnok, K., Aouad, H. E., Micska, B., Schlett, K., & Szücs, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-82775-3 · Cited by 38 · see citing works
Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery
Tanaka, M. (2026) · Biomedicines · doi:10.3390/biomedicines14061265
- Authors
- Debanne, D., & Russier, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Debanne, Dominique
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 166
- Pages
- 107095
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2974430957
- Cited by
- 38
- References
- 108
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 14 · 2023: 6 · 2022: 1 · 2021: 7 · 2020: 2
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurobiology of Learning and Memory (acceptedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- intrinsic plasticity, ion channels, synaptic plasticity, voltage-gated ion channels, neuronal excitability, GABAergic interneurons, spike threshold, resting membrane potential, learning rules, ion channel modulation
- MeSH terms
- Action Potentials, Animals, Brain, Ion Channels, Learning, Memory, Synaptic Transmission, Neuronal Plasticity, Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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