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AU-rich elements and associated factors: are there unifying principles?

Barreau, C.·2005·Nucleic Acids Research
DOI 10.1093/nar/gki1012PMC PMC1325018
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  • Some ARE-binding proteins are mRNA destabilizing inducers, while others can protect the mRNA from endonuclease cleavage.

    “Some ARE-BPs are mRNA destabilizing inducers, while others can protect the mRNA from endonuclease cleavage”

    From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [18]

    The paper’s ‘Functional Relationships Between ARE-BPs’ section says that most identified ARE-binding proteins have been implicated in mRNA degradation, while its ‘Hu family’ section reports that HuR binding increases mRNA stability. It does not say that stabilizing proteins protect mRNA specifically from endonuclease cleavage; the degradation mechanisms it discusses include deadenylation and exonuclease activity. (LLM, conf=0.88)

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Metadata

Authors
Barreau, C.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2005-12-09
Volume
33
Issue
22
Pages
7138-7150
ISSN
  • 0305-1048
  • 1362-4962
DOI
10.1093/nar/gki1012
PMC
PMC1325018
Cited by
907
References
5
Language
en

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