Emerging roles for ncRNAs in alcohol use disorders

Mayfield, R. Dayne

doi:10.1016/j.alcohol.2017.01.004

Cited by 43Cancer-related molecular mechanisms researchNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Emerging roles for ncRNAs in alcohol use disorders

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Mayfield, R. Dayne·2017·Alcohol

DOI 10.1016/j.alcohol.2017.01.004PMC PMC5504532

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Abstract

Chronic alcohol exposure produces widespread neuroadaptations and alterations in gene expression in human alcoholics and animal models. Technological advances in the past decade have increasingly highlighted the role of non-protein-coding RNAs (ncRNAs) in the regulation of gene expression and function. These recently characterized molecules were discovered to mediate diverse processes in the central nervous system, from normal development and physiology to regulation of disease, including alcoholism and other psychiatric disorders. This review will investigate the recent studies in human alcoholics and rodent models that have profiled different classes of ncRNAs and their dynamic alcohol-dependent regulation in brain.

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The importance of ncRNAs is becoming increasingly apparent, not only in alcohol dependence but in brain physiology in general.
“However, the importance of ncRNAs is becoming increasingly apparent, not only in alcohol dependence (36) , but in brain physiology in general (37) , and these RNAs were therefore included in our data.”
From Single cell transcriptome profiling of the human alcohol-dependent brain (2020) · cites this paper as [36]

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Authors: Mayfield, R. D.
Affiliations: The University of Texas at Austin (US)
Corresponding author: Mayfield, R. Dayne
ORCID: Mayfield, R. Dayne
Venue: Alcohol
Publisher: Elsevier BV
Published: 2017-05
Volume: 60
Pages: 31-39
ISSN: 0741-8329 (ISSN-L)
DOI: 10.1016/j.alcohol.2017.01.004
PMC: PMC5504532
OpenAlex: W2607367245
Cited by: 43
References: 97
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 11 · 2018: 11 · 2017: 2
FWCI: 0.78
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Alcohol (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01 AA012404, U01 AA020926, P01 AA020683)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: non-coding RNA, alcoholism, chronic ethanol exposure, gene expression regulation, neural adaptation, brain, mental illness, rodent models
MeSH terms: Alcohol Drinking, Alcoholism, Animals, Brain, Gene Expression Regulation, Humans, MicroRNAs, RNA, Long Noncoding

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