A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock
Abstract
The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch–fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.
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Wet-lab data from just three studies, [105-107], have been reused by simulation studies.
“When comparing Fig 6 and S1 Fig, we find that the wet-lab data from just three studies, namely from [105–107], have been reused by simulation studies.”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [107]
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The dorsal neural tube: A dynamic setting for cell fate decisions
Krispin, S., Nitzan, E., & Kalcheim, C. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20826 · Cited by 82 · see citing works
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Modeling oscillatory control in NF-κB, p53 and Wnt signaling
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High-resolution timing of cell cycle-regulated gene expression
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Notch Signaling in Cardiovascular Disease and Calcification
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Dissecting the dynamics of the Hes1 genetic oscillator
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The vertebrate segmentation clock: the tip of the iceberg
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A Combinatorial Code for Pattern Formation in Drosophila Oogenesis
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Interfering with Wnt signalling alters the periodicity of the segmentation clock
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An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells
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What are you synching about? Emerging complexity of Notch signaling in the segmentation clock
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Oscillator mechanism of notch pathway in the segmentation clock
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- Authors
- Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O.
- Affiliations
- Howard Hughes Medical Institute, Kansas City, MO 64110, USA.
- Stowers Institute for Medical Research (US)
- Venue
- Science
- Published
- 2006-12-08
- Volume
- 314
- Issue
- 5805
- Pages
- 1595-1598
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068329746
- Cited by
- 460
- References
- 21
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 9 · 2022: 17 · 2021: 21 · 2020: 17 · 2019: 20 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 20 · 2013: 23 · 2012: 34
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- segmentation clock, presomitic mesoderm, somitogenesis, cyclic gene expression, Notch signaling, FGF signaling, Wnt signaling, signaling pathways, mouse embryo, vertebral segmentation
- MeSH terms
- Algorithms, Animals, Fibroblast Growth Factors, Multigene Family, Hybrid Cells, Mesoderm, Transcription, Genetic, Signal Transduction, Glycosyltransferases, Gene Expression Regulation, Developmental, Somites, Body Patterning, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MAP Kinase Signaling System, Embryonic Development, Wnt Proteins, Mice, Receptors, Notch
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