Cited by 460Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerGenomics and Chromatin Dynamics

A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock

Dequéant, Mary-Lee, Glynn, Earl, Gaudenz, Karin, Wahl, Matthias, Chen, Jie, Mushegian, Arcady, Pourquié, Olivier·2006·Science

Abstract

The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch–fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.

Integrity signals

Registry

Crossref · 10.1126/science.1133141

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O.
Affiliations
  • Howard Hughes Medical Institute, Kansas City, MO 64110, USA.
  • Stowers Institute for Medical Research (US)
Venue
Science
Published
2006-12-08
Volume
314
Issue
5805
Pages
1595-1598
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2068329746
Cited by
460
References
21
Citations by year
2026: 7 · 2025: 12 · 2024: 18 · 2023: 9 · 2022: 17 · 2021: 21 · 2020: 17 · 2019: 20 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 20 · 2013: 23 · 2012: 34
FWCI
18.64
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
segmentation clock, presomitic mesoderm, somitogenesis, cyclic gene expression, Notch signaling, FGF signaling, Wnt signaling, signaling pathways, mouse embryo, vertebral segmentation
MeSH terms
Algorithms, Animals, Fibroblast Growth Factors, Multigene Family, Hybrid Cells, Mesoderm, Transcription, Genetic, Signal Transduction, Glycosyltransferases, Gene Expression Regulation, Developmental, Somites, Body Patterning, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MAP Kinase Signaling System, Embryonic Development, Wnt Proteins, Mice, Receptors, Notch

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review