A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Jho, E., Zhang, T., Domon–Dell, C., Joo, C., Freund, J., & Costantini, F. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1172-1183.2002 · Cited by 1,683

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M. L., Calabro, A., Kubalak, S., Klewer, S. E., & McDonald, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10272 · Cited by 901

FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation.

Dubrulle, J., McGrew, M., & Pourquié, O. (2001) · Cell · doi:10.1016/s0092-8674(01)00437-8 · Cited by 713

Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis

Aulehla, A., Wehrle, C., Brand‐Saberi, B., Kemler, R., Gossler, A., Kanzler, B., & Herrmann, B. G. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00055-8 · Cited by 593

The Segmentation Clock: Converting Embryonic Time into Spatial Pattern

Pourquié, O. (2003) · Science · doi:10.1126/science.1085887 · Cited by 530

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed

Minowada, G., Jarvis, L. A., Chi, C. L., Neubüser, A., Sun, X., Hacohen, N., Krasnow, M. A., & Martin, G. R. (1999) · Development · doi:10.1242/dev.126.20.4465 · Cited by 506

c-Myc regulates mammalian body size by controlling cell number but not cell size

Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434

Dynamic Complex Formation During the Yeast Cell Cycle

de Lichtenberg, U., Jensen, L. J., Brunak, S., & Bork, P. (2005) · Science · doi:10.1126/science.1105103 · Cited by 405

FGF‐20 and DKK1 are transcriptional targets of β‐catenin and FGF‐20 is implicated in cancer and development

Chamorro, M., Schwartz, D. R., Vonica, A., Brivanlou, A. H., Cho, K. R., & VARMUS, H. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600460 · Cited by 300

Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development

Schmitz-Rohmer, D. (2011) · edoc (University of Basel) · doi:10.5451/unibas-005771720

Editorial on Segmentation Focus

Pourquié, O. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21194

Portuguese contributions to the discovery and characterization of the embryonic molecular clock

Pascoal, S., & Palmeirim, I. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072285sp

Molecular and Morphological Characterization of Segmentation in Artemia franciscana

Blachuta, B. J. (2009) · UA Campus Repository (The University of Arizona)

Investigating the localization of an avian hairy homolog (c-Hairy1) protein

Cravo, J. A. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Linking the embryonic clock with temporal collinearity of Hox gene activation

Fernandes, C. S. R. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Development of Early Embryonic Lineages

Wilson, V. A., & Lawson, K. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800043-4.00004-x

Ultradian Oscillation Networks in Somite Segmentation and Other Biological Events

Niwa, Y., Shimojo, H., & Kageyama, R. (2009) · Springer eBooks · doi:10.1007/978-4-431-87704-2_21

Evolving Concepts: The Role of Gene Loss From an Ancestral Genetic Tool-kit in Animal Evolution

Robertis, E. M. D. (2016)

A Modular Gene Regulation Network Model of Artificial Ontogenesis

Ghanem, A. G. (2008) · OhioLink ETD Center (Ohio Library and Information Network)

Synchronization of Hes1 oscillations coordinate and refine condensation formation and patterning of the avian limb skeletonPreprint

Bhat, R., Glimm, T., Linde‐Medina, M., Cui, C., & Newman, S. A. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/157446

Mechanisms of somite formation and subdivision

Dias, A. S. T. F. (2017) · UCL Discovery (University College London)

How likely are oscillations in a genetic feedback loop with delay?

Cola, F., Marchetti, F., & Tiana, G. (2017) · The European Physical Journal E · doi:10.1140/epje/i2017-11563-y

Nonlinear time-delay dynamical model of oscillatory gene expression in BMP-4/9 vascular endothelial cell network

Yazdi, D. (2014) · eScholarship (California Digital Library)

It takes a lot to make the segmentation clock tick

Goymer, P. (2006) · Nature Reviews Genetics · doi:10.1038/nrg2028

Dynamics of Scaffold Protein Tethered Signal Transduction

Greenwald, E. C. (2015) · doi:10.18130/v39p00

A MicroRNA Based Genetic Clock

Siciliano, V. (2012) · Open Research Online (The Open University) · doi:10.21954/ou.ro.0000f1a6

The effect of Rosovitine on mPSM explants: a real time analysisPreprint

Moya, L. J. M., Bailey, C. S. L., Dale, J. K., & Murray, P. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/789446

The role of PARAXIS as a mediator of epithelial-mesenchymal transitions during the development of the vertebrate musculoskeletal system.

Rowton, M. (2013)

Peptide Chronomics

Franz Halberg, A., Pan, W., Bakken, E. E., & Cornélissen, G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385095-9.00253-0

Developmental timing and cell fate maintenance in Caenorhabditis elegans

Traets, J. J. H. (2021) · doi:10.5463/thesis.105

Analysis of the role of the E-(Epithelial) Cadherin in murine lung tumorigenesis

Ceteci, F. (2008) · Online Publication Service of Würzburg University (Würzburg University)

Theoretical biology

Wierling, C. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8835

A propos de gradients et d'oscillations : le rôle de la voie de signalisation Wnt dans la formation des somites au cours du développement embryonnaire

Aulehla, A. (2008) · HAL

Origen de la muerte embrionaria espontánea en un modelo natural: Lagostomus maximus (vizcacha de llanura)

Acuña, F. (2021) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/129920

Analysis of intronless genes involved in oscillation and differentiation

Osemwenkhae, P. O., & AGUEBOR-OGIE, N. B. (2021) · Journal of applied science and environmental management · doi:10.4314/jasem.v25i9.1

Modelado computacional de la autoorganización espacial generada por circuitos genéticos multicelulares

Regueira, M. R. (2021) · UPM Digital Archive (Technical University of Madrid) · doi:10.20868/upm.thesis.69345

Author response: Paraxial mesoderm organoids model development of human somites

Budjan, C., Liu, S., Ranga, A., Gayen, S., Pourquié, O., & Hormoz, S. (2021) · eLife · doi:10.7554/elife.68925.sa2

Faculty Opinions recommendation of Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion.

Théveneau, E. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726281277.793537870

Nkd2

Wharton, K. A. (2008) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a002442.01

Nkd1

Wharton, K. A. (2007) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a002438.01

Underground decision making; where to grow, when to branch

van den Berg, T. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1293

Bone Developmental Physiology

Lafage‐Proust, M. (2015) · Springer eBooks · doi:10.1007/978-3-662-43596-0_9

Conclusion: Trends and Predictions for Genetic and Developmental Biological Research on Scoliosis

Kusumi, K. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1406-4_10

Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations

Shapiro, F., Wang, J., Flynn, E. A., & Wu, J. Y. (2024) · Biology Open · doi:10.1242/bio.060139

Early organogenesis: Placing and elaborating the organ primordia

Wilson, V. A., & Wymeersch, F. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23739-3.00001-8

Nitric Oxide and its Canonical Pathway Signal Cardiac Progenitors in Chick Embryos

Peterson, D. (2024) · doi:10.46569/0z7095342

Wnt and Fgf signaling pharmacological inhibition affect posterior growth during Tribolium castaneum germband elongationPreprint

Mundaca-Escobar, M., Pardo, R. V., Cepeda, R. E., & Sarrazin, A. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.14.643200

Biological Rhythms: Mechanisms, Functions, and Associated Disorders

Goldbeter, A. (2025) · Lecture notes on mathematical modelling in the life sciences · doi:10.1007/978-3-031-82396-1_3

Oscillation arrest in the mouse somitogenesis clock presumably takes place via an infinite period bifurcationPreprint

Zavala-López, E., & (21853859), M. S. (2011) · arXiv (Cornell University) · doi:10.48550/arxiv.1108.0673

Contribution du modèle drosophile à l'étude des mécanismes de régulation du couplage excitation/contraction cardiaque

Senatore, S. (2010) · theses.fr (ABES) · doi:10.70675/28c23e11zc1c2z420fz9dd8z769bcb22334d

The role of auxin and its signaling pathways in the dynamics and robustness of developmental patterns at the shoot apical meristem

Oliva, M. (2014) · theses.fr (ABES) · doi:10.70675/62687731z5818z40ccz9a43zaaf64015ea68

Analyse de la composition et de la fonction de la machinerie basale de transcription au cours du développement et de la différenciation

Bardot, P. (2018) · theses.fr (ABES) · doi:10.70675/bf0f4eb1z9f05z4ca0z8d1azca4aed938872

Amphioxus illuminates the origin of the vertebrates' head

Aldea, D. (2016) · doi:10.70675/c5ff99baza060z43e1za8d6zc014bd69d4ea

Rôle des gènes de la voie de biosynthèse des purines au cours du développement embryonnaire de Xenopus laevis

Duperray, M. (2017) · doi:10.70675/5e853c96z3cbdz4455zb247z58aa8f44d0e3

La somitogénèse chez les chordés et l’apparition de la tête chez les vertébrés

Meister, L. (2021) · doi:10.70675/60b8b70ez0e15z4668z9564z31c492453294

Rôle du gène Hacd2 au cours de l’embryogenèse et dans la vie postnatale de la souris

Khadhraoui, N. (2020) · doi:10.70675/8f29a451z5dc7z4166z9ce2zd76a565e1b16

The fly eye as a model system to study the molecular basis of developmental speed

Guo, Y. (2023) · theses.fr (ABES) · doi:10.70675/715fb5afzdb09z442fza098za1e2f1c71b0c

Investigating trapezius muscle development in the mouse embryo

Dumas, C. E. (2024) · doi:10.70675/7f4ad2ffz52d7z4914za677zae17c215ff98

Dynamique des systèmes chimiques loin de l'équilibre : approches microscopiques et mésoscopiques

Dziekan, P. (2014) · doi:10.70675/2779fcb7z1f3az411fz9536zced5806ed910

Perturbation of Rac1 signaling alters segmentation clock dynamics and somite size

Pappa, M., & Tsiairis, C. D. (2026) · Development · doi:10.1242/dev.205231

OscillomeR infers ultradian oscillations and targets of the Hes family

Xu, X., & Serup, P. (2026) · Patterns · doi:10.1016/j.patter.2026.101612

A genetically encoded redox bottleneck constrains human developmental rate

Valdebenito, G. E., Madden, J. P., Mendez, C., Azurdia, L. M., Zhu, X., Chen, S., Atlas, D., Introcaso, K., Zhang, H., 王, 亚., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.10.750701

Normal Somitogenesis Despite the Absence of Snai1 in the Presomitic MesodermPreprint

Casaca, A., Aires, R., Nóvoa, A., & Mallo, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.27.762210

From Oscillations to Patterning

Purnell, B. A. (2006) · Science s STKE · doi:10.1126/stke.3652006tw421

Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways

Goldbeter, A., & Pourquié, O. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.01.006 · Cited by 176

It takes a lot to make the segmentation clock tick

Goymer, P. (2006) · Nature Reviews Genetics · doi:10.1038/nrg2028

The vertebrate segmentation clock: the tip of the iceberg

Özbudak, E. M., & Pourquié, O. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.06.007 · Cited by 71

Building the Spine: The Vertebrate Segmentation ClockPreprint

Pourquié, O. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.016 · Cited by 15