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A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock
Abstract
The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch–fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.
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“When comparing Fig 6 and S1 Fig, we find that the wet-lab data from just three studies, namely from [105–107], have been reused by simulation studies.”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [107]
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Metadata
- Authors
- Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O.
- Affiliations
- Howard Hughes Medical Institute, Kansas City, MO 64110, USA.
- Stowers Institute for Medical Research (US)
- Venue
- Science
- Published
- 2006-12-08
- Volume
- 314
- Issue
- 5805
- Pages
- 1595-1598
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068329746
- Cited by
- 460
- References
- 21
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 9 · 2022: 17 · 2021: 21 · 2020: 17 · 2019: 20 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 20 · 2013: 23 · 2012: 34
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- segmentation clock, presomitic mesoderm, somitogenesis, cyclic gene expression, Notch signaling, FGF signaling, Wnt signaling, signaling pathways, mouse embryo, vertebral segmentation
- MeSH terms
- Algorithms, Animals, Fibroblast Growth Factors, Multigene Family, Hybrid Cells, Mesoderm, Transcription, Genetic, Signal Transduction, Glycosyltransferases, Gene Expression Regulation, Developmental, Somites, Body Patterning, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MAP Kinase Signaling System, Embryonic Development, Wnt Proteins, Mice, Receptors, Notch
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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