The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission
Abstract
The 1918 influenza pandemic was a catastrophic series of virus outbreaks that spread across the globe. Here, we show that only a modest change in the 1918 influenza hemagglutinin receptor binding site alters the transmissibility of this pandemic virus. Two amino acid mutations that cause a switch in receptor binding preference from the human α-2,6 to the avian α-2,3 sialic acid resulted in a virus incapable of respiratory droplet transmission between ferrets but that maintained its lethality and replication efficiency in the upper respiratory tract. Furthermore, poor transmission of a 1918 virus with dual α-2,6 and α-2,3 specificity suggests that a predominant human α-2,6 sialic acid binding preference is essential for optimal transmission of this pandemic virus. These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals.
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Cites
Influenza virus receptors in the human airway
Shinya, K., Ebina, M., Yamada, S., Ono, M., Kasai, N., & Kawaoka, Y. (2006) · Nature · doi:10.1038/440435a · Cited by 1,398
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
Self-citationStevens, J., Blixt, O., Glaser, L., Taubenberger, J. K., Palese, P., Paulson, J. C., & Wilson, I. A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.11.002 · Cited by 613
Self-citationOrigin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene
Reid, A. H., Fanning, T. G., Hultin, J. V., & Taubenberger, J. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1651 · Cited by 607
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
Kash, J. C., Tumpey, T. M., Proll, S. C., Carter, V., Perwitasari, O., Thomas, M. J., Basler, C. F., Palese, P., Taubenberger, J. K., García-Sastre, A., et al. (2006) · Nature · doi:10.1038/nature05181 · Cited by 551
Self-citationFrost, W. H. (1920) · Public Health Reports (1896-1970) · doi:10.2307/4575511 · Cited by 118
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Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc
Anthony, R. M., Nimmerjahn, F., Ashline, D. J., Reinhold, V. N., Paulson, J. C., & Ravetch, J. V. (2008) · Science · doi:10.1126/science.1154315 · Cited by 849
Influenza A viruses: new research developments
Medina, R. A., & García-Sastre, A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2613 · Cited by 677
Host and viral determinants of influenza A virus species specificity
Long, J. S., Mistry, B., Haslam, S. M., & Barclay, W. S. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0115-z · Cited by 667
Perrone, L. A., Plowden, J. K., García-Sastre, A., Katz, J. M., & Tumpey, T. M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000115 · Cited by 623
Self-citationInfluenza virus-induced lung injury: pathogenesis and implications for treatment
Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 503
Metadata
- Authors
- Tumpey, T. M., Maines, T. R., Van Hoeven, N., Glaser, L., Solórzano, A., Pappas, C., Cox, N. J., Swayne, D. E., Palese, P., Katz, J. M., & García-Sastre, A.
- Venue
- Science
- Published
- 2007-02-02
- Volume
- 315
- Issue
- 5812
- Pages
- 655-659
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049740179
- Cited by
- 576
- References
- 6
- FWCI
- 35.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tumpey, T. M., Maines, T. R., Van Hoeven, N., Glaser, L., Solórzano, A., Pappas, C., Cox, N. J., Swayne, D. E., Palese, P., Katz, J. M., & García-Sastre, A. (2007). A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission. Science. https://doi.org/10.1126/science.1136212
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
