The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors
Abstract
Smell is an ancient sensory system present in organisms from bacteria to humans. In the nematode Caeonorhabditis elegans , gustatory and olfactory neurons regulate aging and longevity. Using the fruit fly, Drosophila melanogaster , we showed that exposure to nutrient-derived odorants can modulate life span and partially reverse the longevity-extending effects of dietary restriction. Furthermore, mutation of odorant receptor Or83b resulted in severe olfactory defects, altered adult metabolism, enhanced stress resistance, and extended life span. Our findings indicate that olfaction affects adult physiology and aging in Drosophila , possibly through the perceived availability of nutritional resources, and that olfactory regulation of life span is evolutionarily conserved.
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Cites
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573
Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
Alcedo, J., & Kenyon, C. (2004) · Neuron · doi:10.1016/s0896-6273(03)00816-x · Cited by 388
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Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Sexual selection, sexual conflict and the evolution of ageing and life span
Bonduriansky, R., Maklakov, A., Zajitschek, F., & Brooks, R. (2008) · Functional Ecology · doi:10.1111/j.1365-2435.2008.01417.x · Cited by 542
Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster
Skorupa, D. A., Dervisefendic, A., Zwiener, J., & Pletcher, S. D. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00400.x · Cited by 437
Self-citationNeuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding
Waterson, M. J., & Horvath, T. L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.026 · Cited by 434
Metadata
- Authors
- Libert, S., Zwiener, J., Chu, X., VanVoorhies, W., Roman, G., & Pletcher, S. D.
- Venue
- Science
- Published
- 2007-02-23
- Volume
- 315
- Issue
- 5815
- Pages
- 1133-1137
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2141478455
- Cited by
- 407
- References
- 2
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Libert, S., Zwiener, J., Chu, X., VanVoorhies, W., Roman, G., & Pletcher, S. D. (2007). Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors. Science. https://doi.org/10.1126/science.1136610
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