Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons

Alcedo, Joy; Kenyon, Cynthia

doi:10.1016/s0896-6273(03)00816-x

Cited by 388Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology ResearchNematode management and characterization studies

Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons

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Alcedo, Joy, Kenyon, Cynthia·2004·Neuron

DOI 10.1016/s0896-6273(03)00816-x

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Abstract

The life span of C. elegans is extended by mutations that inhibit the function of sensory neurons. In this study, we show that specific subsets of sensory neurons influence longevity. We find that certain gustatory neurons inhibit longevity, whereas others promote longevity, most likely by influencing insulin/IGF-1 signaling. Olfactory neurons also influence life span, and they act in a distinct pathway that involves the reproductive system. In addition, we find that a putative chemosensory G protein-coupled receptor that is expressed in some of these sensory neurons inhibits longevity. Together our findings imply that the life span of C. elegans is regulated by environmental cues and that these cues are perceived and integrated in a complex and sophisticated fashion by specific chemosensory neurons.

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Ablating specific neurons can increase lifespan in worms and flies.
“Furthermore, ablation of specific neurons can increase lifespan in worms (91) and flies (67).”
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Authors: Alcedo, J., & Kenyon, C.
Affiliations: University of California, San Francisco (US)
Corresponding author: Kenyon, Cynthia
ORCID: Alcedo, Joy
Kenyon, Cynthia
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-01
Volume: 41
Issue: 1
Pages: 45-55
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(03)00816-x
OpenAlex: W1971374859
Cited by: 388
References: 67
Citations by year: 2026: 10 · 2025: 15 · 2024: 20 · 2023: 17 · 2022: 9 · 2021: 17 · 2020: 15 · 2019: 22 · 2018: 17 · 2017: 19 · 2016: 15 · 2015: 18 · 2014: 14 · 2013: 26 · 2012: 13
FWCI: 6.40
Type: journal article
Language: en
Open access: bronze
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doi.org/10.15223/policy-017 (stm-asf)
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doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Nematode management and characterization studies
Keywords: Caenorhabditis elegans, longevity, lifespan regulation, gustatory neurons, olfactory sensory neurons, sensory neurons, insulin/IGF-1 signaling, reproductive system, environmental cues, aging
MeSH terms: Animals, Denervation, Fatty Acids, Feeding Behavior, Gonads, Longevity, Membrane Proteins, Neurons, Afferent, Pheromones, Receptor, Insulin, Taste, Signal Transduction, Caenorhabditis elegans, Olfactory Receptor Neurons, GTP-Binding Protein alpha Subunits, Gi-Go, Caenorhabditis elegans Proteins

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Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons

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