The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period
Abstract
By screening N -ethyl- N -nitrosourea–mutagenized animals for alterations in rhythms of wheel-running activity, we identified a mouse mutation, after hours ( Afh ). The mutation, a Cys 358 Ser substitution in Fbxl3, an F-box protein with leucine-rich repeats, results in long free-running rhythms of about 27 hours in homozygotes. Circadian transcriptional and translational oscillations are attenuated in Afh mice. The Afh allele significantly affected Per2 expression and delayed the rate of Cry protein degradation in Per2::Luciferase tissue slices. Our in vivo and in vitro studies reveal a central role for Fbxl3 in mammalian circadian timekeeping.
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Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
CDD: a Conserved Domain Database for protein classification
Marchler-Bauer, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki069 · Cited by 1,156
Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation
Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A., & Virshup, D. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2795-2807.2005 · Cited by 495
Cited by
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,635
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449
Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376
Metadata
- Authors
- Godinho, S. I. H., Maywood, E. S., Shaw, L., Tucci, V., Barnard, A. R., Busino, L., Pagano, M., Kendall, R., Quwailid, M. M., Romero, M. R., O'Neill, J., Chesham, J. E., Brooker, D., Lalanne, Z., Hastings, M. H., & Nolan, P. M.
- Venue
- Science
- Published
- 2007-05-11
- Volume
- 316
- Issue
- 5826
- Pages
- 897-900
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070558630
- Cited by
- 475
- References
- 3
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Godinho, S. I. H., Maywood, E. S., Shaw, L., Tucci, V., Barnard, A. R., Busino, L., Pagano, M., Kendall, R., Quwailid, M. M., Romero, M. R., O'Neill, J., Chesham, J. E., Brooker, D., Lalanne, Z., Hastings, M. H., & Nolan, P. M. (2007). The After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period. Science. https://doi.org/10.1126/science.1141138
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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