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Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ
Abstract
Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKMζ). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.
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“Positive feedback loops that maintain key kinases and other molecules in persistently active states at strengthened synapses may also contribute to such long-term memory storage75–79.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [77]
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Metadata
- Authors
- Shema, R., Sacktor, T. C., & Dudai, Y.
- Affiliations
- SUNY Downstate Health Sciences University (US)
- Corresponding author
- Dudai, Yadin
- Venue
- Science
- Published
- 2007-08-17
- Volume
- 317
- Issue
- 5840
- Pages
- 951-953
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2099036181
- Cited by
- 353
- References
- 32
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 24 · 2016: 18 · 2015: 26 · 2014: 20 · 2013: 36 · 2012: 30
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 57068, R01MH53576, R01MH053576)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- long-term memory, memory persistence, PKMzeta, protein kinase C, memory erasure, neocortex, synaptic plasticity, memory consolidation
- MeSH terms
- Animals, Conditioning, Psychological, Enzyme Inhibitors, Hippocampus, Male, Memory, Oligopeptides, Protein Kinase C, Taste, Time Factors, Rats, Wistar, Neocortex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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