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Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ

Shema, Reut, Sacktor, Todd Charlton, Dudai, Yadin·2007·Science

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Abstract

Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKMζ). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.

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Authors: Shema, R., Sacktor, T. C., & Dudai, Y.
Affiliations: SUNY Downstate Health Sciences University (US)
Corresponding author: Dudai, Yadin
ORCID: Sacktor, Todd Charlton
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2007-08-17
Volume: 317
Issue: 5840
Pages: 951-953
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1144334
OpenAlex: W2099036181
Cited by: 353
References: 32
Citations by year: 2026: 6 · 2025: 1 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 24 · 2016: 18 · 2015: 26 · 2014: 20 · 2013: 36 · 2012: 30
FWCI: 14.49
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 57068, R01MH53576, R01MH053576)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: long-term memory, memory persistence, PKMzeta, protein kinase C, memory erasure, neocortex, synaptic plasticity, memory consolidation
MeSH terms: Animals, Conditioning, Psychological, Enzyme Inhibitors, Hippocampus, Male, Memory, Oligopeptides, Protein Kinase C, Taste, Time Factors, Rats, Wistar, Neocortex, Rats

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Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ

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