Hippocampal infusion of zeta inhibitory peptide impairs recent, but not remote, recognition memory in rats
Open accessAbstract
Spatial memory in rodents can be erased following the infusion of zeta inhibitory peptide (ZIP) into the dorsal hippocampus via indwelling guide cannulas. It is believed that ZIP impairs spatial memory by reversing established late-phase long-term potentiation (LTP). However, it is unclear whether other forms of hippocampus-dependent memory, such as recognition memory, are also supported by hippocampal LTP. In the current study, we tested recognition memory in rats following hippocampal ZIP infusion. In order to combat the limited targeting of infusions via cannula, we implemented a stereotaxic approach for infusing ZIP throughout the dorsal, intermediate, and ventral hippocampus. Rats infused with ZIP 3-7 days after training on the novel object recognition task exhibited impaired object recognition memory compared to control rats (those infused with aCSF). In contrast, rats infused with ZIP 1 month after training performed similar to control rats. The ability to form new memories after ZIP infusions remained intact. We suggest that enhanced recognition memory for recent events is supported by hippocampal LTP, which can be reversed by hippocampal ZIP infusion.
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Post-sample infusions of zeta inhibitory peptide into the rat hippocampus impaired NOP memory.
“Post-sample infusions of zeta inhibitory peptide into the rat hippocampus impaired NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Hales et al., 2015
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- Authors
- Hales, J. B., Ocampo, A. C., Broadbent, N. J., & Clark, R. E.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Clark, Robert E.
- Venue
- Neural Plasticity
- Publisher
- Hindawi Limited
- Published
- 2015
- Volume
- 2015
- Pages
- 1-7
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC4561311
- OpenAlex
- W1663624839
- Cited by
- 7
- References
- 30
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2015: 2
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Medical Research Service of the Department of Veterans Affairs
- NSF Temporal Dynamics of Learning Center
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- recognition memory, hippocampus, long-term potentiation, novel object recognition, spatial memory, memory consolidation
- MeSH terms
- Animals, Hippocampus, Learning, Male, Memory, Short-Term, Microinjections, Psychomotor Performance, Space Perception, Stereotaxic Techniques, Long-Term Potentiation, Rats, Long-Evans, Recognition, Psychology, Rats, Lipopeptides, Memory, Long-Term, Cell-Penetrating Peptides
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