The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ
Abstract
Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKMζ). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.
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“Positive feedback loops that maintain key kinases and other molecules in persistently active states at strengthened synapses may also contribute to such long-term memory storage75–79.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [77]
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Self-citationRites of Passage of the Engram
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Self-citationProtein kinase Mζ is necessary and sufficient for LTP maintenance
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Metadata
- Authors
- Shema, R., Sacktor, T. C., & Dudai, Y.
- Affiliations
- SUNY Downstate Health Sciences University (US)
- Corresponding author
- Dudai, Yadin
- Venue
- Science
- Published
- 2007-08-17
- Volume
- 317
- Issue
- 5840
- Pages
- 951-953
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2099036181
- Cited by
- 353
- References
- 32
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 24 · 2016: 18 · 2015: 26 · 2014: 20 · 2013: 36 · 2012: 30
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 57068, R01MH53576, R01MH053576)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- long-term memory, memory persistence, PKMzeta, protein kinase C, memory erasure, neocortex, synaptic plasticity, memory consolidation
- MeSH terms
- Animals, Conditioning, Psychological, Enzyme Inhibitors, Hippocampus, Male, Memory, Oligopeptides, Protein Kinase C, Taste, Time Factors, Rats, Wistar, Neocortex, Rats
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