Gene regulation by transcription factors and microRNAs
Abstract
The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor– and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.
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miRNAs can influence transcription by regulating the translation of transcriptional factors.
“miRNAs can also influence transcription by regulating the translation of transcriptional factors (Hobert, 2008).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Hobert, 2008
Cites
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- Authors
- Hobert, O.
- Affiliations
- Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA.
- Venue
- Science
- Published
- 2008-03-28
- Volume
- 319
- Issue
- 5871
- Pages
- 1785-1786
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 761
- References
- 2
- Language
- en
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