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Cited by 1,202

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin

Hanna, Jacob, Wernig, Marius, Markoulaki, Styliani, Sun, Chiao-Wang, Meissner, Alexander, Cassady, John P., Beard, Caroline, Brambrink, Tobias, Wu, Li-Chen, Townes, Tim M., Jaenisch, Rudolf·2007·Science
DOI 10.1126/science.1152092
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Abstract

It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed into an embryonic stem cell–like state by introducing combinations of four transcription factors. However, the therapeutic potential of such induced pluripotent stem (iPS) cells remained undefined. By using a humanized sickle cell anemia mouse model, we show that mice can be rescued after transplantation with hematopoietic progenitors obtained in vitro from autologous iPS cells. This was achieved after correction of the human sickle hemoglobin allele by gene-specific targeting. Our results provide proof of principle for using transcription factor–induced reprogramming combined with gene and cell therapy for disease treatment in mice. The problems associated with using retroviruses and oncogenes for reprogramming need to be resolved before iPS cells can be considered for human therapy.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.1152092

Cites

4 of 4 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 4 references

Research works printed but not linked: 16

  1. 10.1016/j.blre.2005.01.005 · DOI
  2. 10.1056/NEJMp048304 · DOI
  3. 10.1016/S0092-8674(02)00681-5 · DOI
  4. 10.1038/439145a · DOI
  5. 10.1016/j.stem.2007.05.014 · DOI · Paper page
  6. 10.1016/j.cell.2007.11.019 · DOI · Paper page
  7. 10.1038/nature05944 · DOI
  8. 10.1016/j.stem.2007.08.008 · DOI
  9. 10.1038/nbt1335 · DOI
  10. 10.1016/S0092-8674(02)00680-3 · DOI · Paper page
  11. 10.1038/nature05934 · DOI
  12. 10.1101/gad.1524207 · DOI
  13. 10.1073/pnas.0506127102 · DOI
  14. 10.1182/blood-2006-02-004812 · DOI
  15. 10.1126/science.278.5339.873 · DOI
  16. 10.1038/nature04955 · DOI

Cited by

Metadata

Authors
Hanna, J., Wernig, M., Markoulaki, S., Sun, C.-W., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L.-C., Townes, T. M., & Jaenisch, R.
Affiliations
The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2007-12-21
Volume
318
Issue
5858
Pages
1920-1923
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1152092
Cited by
1,202
References
4
Language
en

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