Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice
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A major obstacle in the application of cell-based therapies for the treatment of neuromuscular disorders is obtaining the appropriate number of stem/progenitor cells to produce effective engraftment. The use of embryonic stem (ES) or induced pluripotent stem (iPS) cells could overcome this hurdle. However, to date, derivation of engraftable skeletal muscle precursors that can restore muscle function from human pluripotent cells has not been achieved. Here we applied conditional expression of PAX7 in human ES/iPS cells to successfully derive large quantities of myogenic precursors, which, upon transplantation into dystrophic muscle, are able to engraft efficiently, producing abundant human-derived DYSTROPHIN-positive myofibers that exhibit superior strength. Importantly, transplanted cells also seed the muscle satellite cell compartment, and engraftment is present over 11 months posttransplant. This study provides the proof of principle for the derivation of functional skeletal myogenic progenitors from human ES/iPS cells and highlights their potential for future therapeutic application in muscular dystrophies.
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Human pluripotent stem cells induced to express PAX7 and treated with defined chemical cocktails yield transplantable muscle progenitors that refill the satellite cell niche and maintain dystrophin-positive fibers in dystrophin-deficient mice.
“Induced expression of PAX7 and exposure to defined chemical cocktails145–147 in human pluripotent stem cells has been shown to generate engraftable muscle progenitor cells that replenish the satellite cell compartment and sustain formation of dystrophin-positive myofibers in dystrophin-deficient mice145,147.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [147]
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- Authors
- Darabi, R., Arpke, R. W., Irion, S., Dimos, J. T., Grskovic, M., Kyba, M., & Perlingeiro, R. C. R.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Perlingeiro, Rita C.R.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 10
- Issue
- 5
- Pages
- 610-619
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3348507
- OpenAlex
- W1990897270
- Cited by
- 481
- References
- 45
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 26 · 2023: 28 · 2022: 40 · 2021: 33 · 2020: 38 · 2019: 40 · 2018: 38 · 2017: 32 · 2016: 35 · 2015: 44 · 2014: 42 · 2013: 34 · 2012: 19
- FWCI
- 17.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R21AG034370)
- National Institute of General Medical Sciences (P01GM081627)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR055299, RC1AR058118, RC2AR058919, R01AR055685)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- myogenic progenitor cells, embryonic stem cells, induced pluripotent stem cells, Duchenne muscular dystrophy, dystrophin, Pax7, skeletal muscle regeneration, cell transplantation, engraftment, satellite cells, muscle contractility, cell therapy, neuromuscular disorders
- MeSH terms
- Animals, Feasibility Studies, Humans, Muscle Contraction, Muscular Dystrophies, Transplantation, Heterologous, Dystrophin, Mice, Inbred mdx, Satellite Cells, Skeletal Muscle, Stem Cell Transplantation, Cell Proliferation, Mice, PAX7 Transcription Factor, Embryonic Stem Cells, Induced Pluripotent Stem Cells
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