The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Targeting QseC Signaling and Virulence for Antibiotic Development
Open accessAbstract
Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 is not toxic and does not inhibit pathogen growth; however, this compound markedly inhibits the virulence of several pathogens in vitro and in vivo in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs.
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Cites
Bacteria–host communication: the language of hormones
Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P., & Kaper, J. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537100100 · Cited by 902
Self-citationThe biology and future prospects of antivirulence therapies
Cegelski, L., Marshall, G. R., Eldridge, G. R., & Hultgren, S. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1818 · Cited by 788
Inter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761
Self-citation
Cited by
A brief history of the antibiotic era: lessons learned and challenges for the future
Aminov, R. I. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00134 · Cited by 1,628
Anti-virulence strategies to combat bacteria-mediated disease
Rasko, D. A., & Sperandio, V. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3013 · Cited by 1,373
Self-citationVerocytotoxin-producing Escherichia coli (VTEC)
Karmali, M. A., Gannon, V., & Sargeant, J. M. (2010) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.04.011 · Cited by 543
Quorum sensing in bacterial virulence
Antunes, L. C. M., Ferreira, R. B. R., Buckner, M. M. C., & Finlay, B. B. (2010) · Microbiology · doi:10.1099/mic.0.038794-0 · Cited by 537
Antibacterial mechanisms of cinnamon and its constituents: A review
Vasconcelos, N. G., Croda, J., & Simionatto, S. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.04.036 · Cited by 522
Metadata
- Authors
- Rasko, D. A., Moreira, C. G., Li, D. R., Reading, N. C., Ritchie, J. M., Waldor, M. K., Williams, N., Taussig, R., Wei, S., Roth, M., Hughes, D. T., Huntley, J. F., Fina, M. W., Falck, J. R., & Sperandio, V.
- Venue
- Science
- Published
- 2008-08-22
- Volume
- 321
- Issue
- 5892
- Pages
- 1078-1080
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023184347
- Cited by
- 519
- References
- 3
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Rasko, D. A., Moreira, C. G., Li, D. R., Reading, N. C., Ritchie, J. M., Waldor, M. K., Williams, N., Taussig, R., Wei, S., Roth, M., Hughes, D. T., Huntley, J. F., Fina, M. W., Falck, J. R., & Sperandio, V. (2008). Targeting QseC Signaling and Virulence for Antibiotic Development. Science. https://doi.org/10.1126/science.1160354
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