Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

Park, Kevin Kyungsuk, Liu, Kai, Hu, Yang, Smith, Patrice D., Wang, Chen, Cai, Bin, Xu, Bengang, Connolly, Lauren +3 more·2008·Science

DOI 10.1126/science.1161566

Cited by (1,001)

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Yi Zhang, Yuji Ueno, Xianshuang Liu, Benjamin Buller, Xinli Wang, Michael Chopp, Zheng Gang Zhang · 2013 · Journal of Neuroscience
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Emily P. Harrington, Chao Zhao, Stephen P.J. Fancy, Sovann Kaing, Robin J.M. Franklin, David H. Rowitch · 2010 · Annals of Neurology
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Alexandra B. Byrne, Trent J. Walradt, Kathryn E. Gardner, Austin Hubbert, V Reinke, Marc Hammarlund · 2014 · Neuron
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Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model
H-Y Lopilly Park, J H Kim, Chanjoon Park · 2012 · Cell Death and Disease
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MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
Chang-Mei Liu, Rui-Ying Wang, Saijilafu, Zhong-Xian Jiao, Bo-Yin Zhang, Feng‐Quan Zhou · 2013 · Genes & Development
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John H. Lee, Luis Tecedor, Yong Hong Chen, Alex Mas, Matthew J. Sowada, Leslie Michels Thompson, Beverly L. Davidson · 2014 · Neuron
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Dietmar Fischer, Marco Leibinger · 2012 · Progress in Retinal and Eye Research
Spatial and temporal arrangement of neuronal intrinsic and extrinsic mechanisms controlling axon regeneration
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Zhao Zhong Chong, Yan Shang, Lijie Zhang, Shaohui Wang, Kenneth Maiese · 2010 · Oxidative Medicine and Cellular Longevity
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Sarah A. Busch, Jason A. Hamilton, Kevin P. Horn, Fernando X. Cuascut, Rochelle Cutrone, Nicholas Lehman, Robert Deans, Anthony E. Ting, Robert W. Mays, Jerry Silver · 2011 · Journal of Neuroscience
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Apostolia Fragkouli, Epaminondas Doxakis · 2014 · Frontiers in Cellular Neuroscience
Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis
Dimitri Cloëtta, Venus Thomanetz, Constanze Baranek, Regula M. Lustenberger, Shuo Lin, Filippo Oliveri, Suzana Atanasoski, Markus A. Rüegg · 2013 · Journal of Neuroscience
Oligodendrocyte-Myelin Glycoprotein and Nogo Negatively Regulate Activity-Dependent Synaptic Plasticity
Stephen J. Raiker, Hakjoo Lee, Katherine T. Baldwin, Yuntao Duan, Peter G. Shrager, Roman J. Giger · 2010 · Journal of Neuroscience
Cell intrinsic control of axon regeneration
Fernando Milhazes Mar, Azad Bonni, Mónica Mendes Sousa · 2014 · EMBO Reports
Emergent properties of neural repair: elemental biology to therapeutic concepts
Stanley Thomas Carmichael · 2016 · Annals of Neurology
Dopaminergic pathway reconstruction by Akt/Rheb‐induced axon regeneration
Sang Ryong Kim, Xiqun Michael Chen, Tinmarla Frances Oo, Tatyana Kareva, Olga Yarygina, Chuansong Wang, Matthew J. During, Nikolai G. Kholodilov, Robert E. Burke · 2011 · Annals of Neurology
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Young-Don Kwak, Tao Ma, Shiyong Diao, Xue Zhi Zhang, Yaomin Chen, Janet Hsu, Stuart A. Lipton, Eliezer Masliah, Huaxi Xu, Francesca‐Fang Liao · 2010 · Molecular Neurodegeneration
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Feng Li, Armin Sami, Harun Najib Noristani, Kieran Slattery, Jingyun Qiu, Thomas R. Groves, Shuo Wang, Kelly Veerasammy, Yuki X. Chen, Jorge Morales et al. · 2020 · Cell Metabolism
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Shuji Wakatsuki, Fuminori Saitoh, Toshiyuki Araki · 2011 · Nature Cell Biology
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia
Jing Wang, Xuelian He, Huyan Meng, Yi Li, Phillip Dmitriev, Feng Tian, Jessica C. Page, Qing Richard Lu, Zhigang He · 2020 · Neuron
Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury
Gang Liu, M. Detloff, Kassi Miller, Lauren Santi, J. Houlé · 2011 · Experimental Neurology
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Ilse Bollaerts, Jessie Van houcke, Lien Andries, Lies De Groef, Lieve Moons · 2017 · Mediators of Inflammation
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Hsiao-Chun Cheng, Sang Ryong Kim, Tinmarla Frances Oo, Tatyana Kareva, Olga Yarygina, Margarita Rzhetskaya, Chuansong Wang, Matthew J. During, Zsolt Tallóczy, Keiji Tanaka et al. · 2011 · Journal of Neuroscience
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Vincent Pernet, Sandrine Joly, Deniz Dalkara, Noémie Jordi, Olivia Schwarz, Franziska Christ, David V. Schaffer, John G. Flannery, Martin E. Schwab · 2012 · Neurobiology of Disease
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Xiangyong Wei, Lingfei Luo, Jin-Zi Chen · 2019 · Cells
JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death
Kimberly A. Fernandes, Jeffrey M. Harder, Laura Beth Fornarola, Robert S. Freeman, Abbot F. Clark, Iok‐Hou Pang, Simon W. M. John, Richard T. Libby · 2012 · Neurobiology of Disease
Can injured adult CNS axons regenerate by recapitulating development?
Brett J. Hilton, Frank Bradke · 2017 · Development
Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth
Rodrigo López‐Leal, Florencia Díaz-Viraqué, Romina J. Catalán, Cristian Saquel, Anton James Enright, Gregorio Iraola, Felipe A. Court · 2020 · Journal of Cell Science
The DLK signalling pathway—a double‐edged sword in neural development and regeneration
Andrea Tedeschi, Frank Bradke · 2013 · EMBO Reports
Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury
Agostinone, Jessica, Alarcon-Martinez, Luis, Gamlin, Clare, Yu, Wan-Qing, Wong, Rachel O L, Di Polo, Adriana · 2018 · Brain
Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
Marco Leibinger, Charlotte Zeitler, Philipp Gobrecht, Anastasia Andreadaki, Günter Gisselmann, Dietmar Fischer · 2021 · Nature Communications
Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling
Hongjin Wang, Hai-feng Ran, Yue Yin, Xiaogang Xu, Bao-xiang Jiang, Shi-qi Yu, Yijin Chen, Huijing Ren, Shan Feng, Jifen Zhang et al. · 2021 · Acta Pharmacologica Sinica
Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System
Xueting Luo, Márcio Ribeiro, Eric R. Bray, Do-Hun Lee, Benjamin J. Yungher, Saloni T. Mehta, Kinjal Thakor, Francisca Díaz, Jae K. Lee, Carlos Torres Moraes et al. · 2016 · Cell Reports
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Yiling Zhang, Philip Raymond Williams, Anne Jacobi, Chen Wang, Anurag Goel, Arlene A. Hirano, Nicholas C. Brecha, Daniel Kerschensteiner, Zhigang He · 2019 · Neuron
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Robert James Casson, Glyn Chidlow, Jonathan Guy Crowston, Pete A. Williams, John P. M. Wood · 2020 · Progress in Retinal and Eye Research
Cross-talk between KLF4 and STAT3 regulates axon regeneration
Song Qin, Yuhua Zou, Chun‐Li Zhang · 2013 · Nature Communications
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Songshan Li, Chao Yang, Li Zhang, Xin Gao, Xuejie Wang, Wen Liu, Yuqi Wang, Songshan Jiang, Yung Hou Wong, Yifeng Zhang et al. · 2016 · Proceedings of the National Academy of Sciences
PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons
Ke Ning, Carsten Drepper, Chiara F. Valori, Mansoor Ahsan, Matthew Wyles, Adrian Higginbottom, Thomas Herrmann, Pamela J. Shaw, Mimoun Azzouz, Michael Sendtner · 2010 · Human Molecular Genetics
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Feng Tian, Yuyan Cheng, Songlin Zhou, Qianbin Wang, Aboozar Monavarfeshani, Kun Gao, Weiqian Jiang, Riki Kawaguchi, Qing Wang, Mingjun Tang et al. · 2022 · Neuron
Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration
Marco Leibinger, Anastasia Andreadaki, H Diekmann, Dietmar Fischer · 2013 · Cell Death and Disease
Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival
Rossella Russo, Giuseppe Pasquale Varano, Annagrazia Adornetto, Francesca Nazio, Gianluca Tettamanti, Rossana Girardello, Valentina Cianfanelli, Federica Cavaliere, Luigi Antonio Morrone, Maria Tiziana Corasaniti et al. · 2018 · Cell Death and Disease
The role of local protein synthesis and degradation in axon regeneration
Laura F. Gumy, Chin Lik Tan, James W. Fawcett · 2009 · Experimental Neurology
High content screening of cortical neurons identifies novel regulators of axon growth
Murray G. Blackmore, Darcie L. Moore, Robin P. Smith, Jeffrey Louis Goldberg, John L. Bixby, Vance Lemmon · 2010 · Molecular and Cellular Neuroscience
Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration
Xuewei Wang, Qiao Li, Chang-Mei Liu, Philip A. Hall, Jing-Jing Jiang, Christopher D. Katchis, Sehwa Kang, Bryan C. Dong, Shuxin Li, Feng‐Quan Zhou · 2018 · Cell Reports
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead
Raquel Boia, Noelia Ruzafa, Inês Dinis Aires, Xandra Pereiro, António Francisco Ambrósio, Elena Vecino, Ana Raquel Santiago · 2020 · International Journal of Molecular Sciences
Natural and targeted circuit reorganization after spinal cord injury
Mark A. Anderson, Jordan W. Squair, Matthieu Gautier, Thomas Haynes Hutson, Claudia Kathe, Quentin Barraud, Jocelyne Bloch, Grégoire Courtine · 2022 · Nature Neuroscience
Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration
C. Samara, Christopher Rohde, C. Gilleland, Stephanie Norton, S. Haggarty, M. Yanik · 2010 · Proceedings of the National Academy of Sciences of the United States of America
miR‐21 and miR‐19b delivered by hMSC‐derived EVs regulate the apoptosis and differentiation of neurons in patients with spinal cord injury
Guanghui Xu, Rongguang Ao, Zhongzheng Zhi, Jianbo Jia, Baoqing Yu · 2018 · Journal of Cellular Physiology
Mammalian Target of Rapamycin: A Signaling Kinase for Every Aspect of Cellular Life
Thomas Weichhart · 2011 · Methods in molecular biology
Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
C. Nicole Sunnen, Amy L. Brewster, Joaquín N. Lugo, Fabiola Vanegas, Eric Turcios, Shivani Mukhi, Deena Parghi, Gabriella D’Arcangelo, Anne E. Anderson · 2011 · Epilepsia
A Critical Kinase Cascade In Neurological Disorders: Pi3K, Akt and Mtor
Zhao Zhong Chong, Yan Shang, Shaohui Wang, Kenneth Maiese · 2012 · Future Neurology
mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
Linqing Miao, Yang Liu, Haoliang Huang, Feisi Liang, Chen Ling, Yang Hu · 2016 · eLife
Renewed proliferation in adult mouse cochlea and regeneration of hair cells
Yilai Shu, Wenyan Li, Mingqian Huang, Yi‐Zhou Quan, Deborah I. Scheffer, Chunjie Tian, Yong Tao, Xue Zhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian et al. · 2019 · Nature Communications
Advances in Biomaterial‐Based Spinal Cord Injury Repair
He Shen, Caixia Fan, Zhifeng You, Zhifeng Xiao, Yannan Zhao, Jianwu Dai · 2021 · Advanced Functional Materials
Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve
Vincent Pernet, Sandrine Joly, Noémie Jordi, Deniz Dalkara, Anna Guzik-Kornacka, John G. Flannery, Martin E. Schwab · 2013 · Cell Death and Disease
Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
Chong, Zhao Zhong, Shang, Yan Chen, Wang, Shaohui, Maiese, Kenneth · 2012 · Progress in Neurobiology
Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice
Camelia A. Danilov, Oswald Steward · 2015 · Experimental Neurology
Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms
Homaira Nawabi, Stéphane Belin, Romain Cartoni, Philip Raymond Williams, Chen Wang, Alban Latrémolière, Xuhua Wang, Junjie Zhu, Daniel G. Taub, Xiaoqin Fu et al. · 2015 · Neuron
KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS
Akintomide Apara, Joana Galvão, Yan Wang, Murray G. Blackmore, Allison Trillo, Keiichiro Iwao, Dale P. Brown, Kimberly A. Fernandes, Abigail Huang, Tu Nguyen et al. · 2017 · Journal of Neuroscience
Spinal Cord Regeneration
Brian K. Kwon, Wolfram Tetzlaff · 2001 · Spine
Growing the growth cone: remodeling the cytoskeleton to promote axon regeneration
Eun‐Mi Hur, Saijilafu, Feng‐Quan Zhou · 2011 · Trends in Neurosciences
What makes a RAG regeneration associated?
Thong Chi Ma, Dianna E. Willis · 2015 · Frontiers in Molecular Neuroscience
Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury
Kenta Hyeon Tae Cho, Bing Xu, Cherie Blenkiron, Mhoyra Fraser · 2019 · Frontiers in Physiology
Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets
Rabia Akram, Haseeb Anwar, Muhammad Shahid Javed, Azhar Rasul, Ali Imran, Shoaib Ahmad Malik, Chand Raza, Ikram Ullah Khan, Faiqa Sajid, Tehreem Iman et al. · 2022 · Biomedicines
Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system
Sarah Demaré, Asha Kothari, Nigel A. Calcutt, Paul Fernyhough · 2020 · Expert Review of Neurotherapeutics
Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
Chhavy Tep, Tae Hee Lim, Pyung On Ko, Sami Getahun, Jae Cheon Ryu, Virginia M. Goettl, Stephen M. Massa, Michele Basso, Frank M. Longo, Sung Ok Yoon · 2013 · Journal of Neuroscience
Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering
James R. Tribble, Flora Hui, Heberto Quintero, Sana El Hajji, Katharina Cornelia Bell, Adriana Di Polo, Pete A. Williams · 2023 · Molecular Aspects of Medicine
Krüppel-like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration
Darcie L. Moore, Akintomide Apara, Jeffrey Louis Goldberg · 2011 · Molecular and Cellular Neuroscience
Axon regeneration and exercise‐dependent plasticity after spinal cord injury
John D. Houlé, Marie‐Pascale Côté · 2013 · Annals of the New York Academy of Sciences
ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration
Lars Tönges · 2011 · Frontiers in Molecular Neuroscience
microRNA-222 Targeting PTEN Promotes Neurite Outgrowth from Adult Dorsal Root Ganglion Neurons following Sciatic Nerve Transection
Songlin Zhou, Dingding Shen, Yongjun Wang, Leilei Gong, Xiaoyan Tang, Bin Yu, Xiaosong Gu, Fei Ding · 2012 · PLoS ONE
PPARβ/δ: linking metabolism to regeneration
Magadum, Ajit, Engel, Felix B. · 2018 · International Journal of Molecular Sciences
Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice
Cédric G. Geoffroy, Ariana O. Lorenzana, Jeffrey P. Kwan, Kyle M. Lin, Omeed Ghassemi, Andrew Ma, Nuo Xu, Daniel Creger, Kai Liu, Zhigang He et al. · 2015 · Journal of Neuroscience
IL-6 promotes regeneration and functional recovery after cortical spinal tract injury by reactivating intrinsic growth program of neurons and enhancing synapse formation
Ping Yang, Huizhong Wen, Shan Ou, Jian Guo Cui, Dehua Fan · 2012 · Experimental Neurology
Neurotrophic factors for spinal cord repair: Which, where, how and when to apply, and for what period of time?
Alan R. Harvey, Sarah J. Lovett, Bernadette T. Majda, Jun Han Yoon, Lachlan P.G. Wheeler, Stuart I. Hodgetts · 2014 · Brain Research
Distribution of Mesenchymal Stem Cells and Effects on Neuronal Survival and Axon Regeneration after Optic Nerve Crush and Cell Therapy
Louise Alessandra Mesentier-Louro, Camila Zaverucha-do-Valle, Almir Jordão da Silva‐Junior, Gabriel Nascimento‐dos‐Santos, Fernanda Gubert, Beatriz Padilha de Figueirêdo Ana, Ana Luiza Machado Torres, Bruno Diaz Paredes, Camila da Silva Teixeira, Fernanda Freire Tovar-Moll et al. · 2014 · PLoS ONE
Integrins promote axonal regeneration after injury of the nervous system
Bart Nieuwenhuis, Barbara Haenzi, Melissa R. Andrews, Joost Verhaagen, James W. Fawcett · 2018 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
TSC1/TSC2 signaling in the CNS
Han, Juliette M., Sahin, Mustafa · 2011 · FEBS Letters
Retrograde signaling in axonal regeneration
Ida Rishal, Mike Fainzilber · 2009 · Experimental Neurology
Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS.
N. Tassew, Jason Charish, A. Shabanzadeh, V. Luga, Hidekiyo Harada, Nahal Farhani, P. D'Onofrio, Brian K A Choi, Ahmad Ellabban, P. E. Nickerson et al. · 2017 · Cell Reports
Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold
Xin Duan, Arjun Krishnaswamy, Mallory A. Laboulaye, Jinyue Liu, Yi‐Rong Peng, Masahito Yamagata, Kenichi Toma, Joshua R. Sanes · 2018 · Neuron
Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury
Jiu‐Hong Zhao, Yali Ding, Rui He, Kui Huang, Lu Liu, Chaona Jiang, Zhuozhou Liu, Yuanlan Wang, Xiaokai Yan, Fuyang Cao et al. · 2020 · Stem Cell Research & Therapy
Spinal Cord Regeneration
Wise Young · 2014 · Cell Transplantation