Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833

The Biology of Cancer

Weinberg, R. A., & Weinberg, R. A. (2006) · W.W. Norton eBooks · doi:10.1201/9780203852569 · Cited by 1,806

Glial inhibition of CNS axon regeneration

Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,525

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384

Targeting the PI3K-Akt pathway in human cancer

Luo, J., Manning, B. D., & Cantley, L. C. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00248-4 · Cited by 1,290

Degeneration and regeneration of axons in the lesioned spinal cord

Schwab, M. E., & Bartholdi, D. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.2.319 · Cited by 1,124

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,080

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007

Transcriptional landscape of alternative splicing during peripheral nerve injury

Zhao, L., & Yi, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27446 · Cited by 18

Differential Gamma-Synuclein Expression in Acute and Chronic Retinal Ganglion Cell Death in the Retina and Optic Nerve

Liu, Y., Tapia, M. L., Yeh, J., He, R. C., Pomerleu, D., & Lee, R. K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01735-1 · Cited by 18

Combining task-based rehabilitative training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice

Pan, L., Tan, B., Tang, W., Luo, M., Liu, Y., Yu, L., & Yin, Y. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113197 · Cited by 18

Artemin augments survival and axon regeneration in axotomized retinal ganglion cells

Omodaka, K., Kurimoto, T., Nakamura, O., Sato, K., Yasuda, M., Tanaka, Y., Himori, N., Yokoyama, Y., & Nakazawa, T. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23449 · Cited by 18

Evaluation of the Impact of the Cancer Therapy Everolimus on the Central Nervous System in Mice

Dubois, M., Joncour, V. L., Tonon, M., Anouar, Y., Proust, F., Morin, F., Gandolfo, P., Joly, F., Hilber, P., & Castel, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113533 · Cited by 18

The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization.

Gao, Y., Peng, S., Wen, Q., Zheng, C., Lin, J., Tan, Y., Ma, Y., Luo, Y., Xue, Y.-X., Wu, P., et al. (2014) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000650 · Cited by 18

RegenBase: a knowledge base of spinal cord injury biology for translational research

Callahan, A., Abeyruwan, S. W., Al‐Ali, H., Sakurai, K., Ferguson, A. R., Popovich, P. G., Shah, N. H., Visser, U., Bixby, J. L., & Lemmon, V. (2016) · Database · doi:10.1093/database/baw040 · Cited by 18

Selective neuronal PTEN deletion: can we take the brakes off of growth without losing control?

Steward, O., & Gutilla, E. A. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.189160 · Cited by 18

Overcoming Inhibitions

Kim, W.-Y., & Snider, W. D. (2008) · Science · doi:10.1126/science.1166152 · Cited by 18

Do growth-stimulated retinal ganglion cell axons find their central targets after optic nerve injury? New insights by three-dimensional imaging of the visual pathway

Diekmann, H., Leibinger, M., & Fischer, D. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.06.021 · Cited by 17

Network-centric medicine for peripheral nerve injury: treating the whole to boost endogenous mechanisms of neuroprotection and regeneration

Romeo-Guitart, D., & Casas, C. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.251187 · Cited by 17

Buyang Huanwu decoction improves neural recovery after spinal cord injury in rats through the mTOR signaling pathway and autophagy

Nie, Y., Fan, Y., Zhang, X., Li, X., Yin, J., Li, M., Hu, Z., Li, L., & Wang, X. (2021) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2021.1954378 · Cited by 17

Autophagy and polyphenol intervention strategy in aging

Gu, Y., & Han, J. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.12.013 · Cited by 19

Biomaterial-Based bFGF Delivery for Nerve Repair

Huang, Q., Liu, B., & Wu, W.-C. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/8003821 · Cited by 19

Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma

Li, C., Wu, S., Yong-quan, S., Peng, X.-Q., Gong, M., Du, H., Zhang, J., Teng, Z., Wang, N., & Liu, C. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101554 · Cited by 18

In vivo cellular imaging of various stress/response pathways using AAV following axonal injury in mice

Fujita, K., Nishiguchi, K. M., Yokoyama, Y., Tomiyama, Y., Tsuda, S., Yasuda, M., Maekawa, S., & Nakazawa, T. (2015) · Scientific Reports · doi:10.1038/srep18141 · Cited by 18

Optic nerve regeneration in the mouse is a complex trait modulated by genetic background.

Wang, J., Li, Y., King, R., Struebing, F. L., & Geisert, E. E. (2018) · PubMed · Cited by 18

Repulsive Environment Attenuation during Adult Mouse Optic Nerve Regeneration

Goulart, C. O., Mendonça, H. R., Oliveira, J. T., Savoldi, L. M. B., Heringer, L. D. S., dos Santos‐Rodrigues, A., Paes‐de‐Carvalho, R., & Martinez, A. M. B. (2018) · Neural Plasticity · doi:10.1155/2018/5851914 · Cited by 17

Inhibitor of DNA binding 2 promotes axonal growth through upregulation of Neurogenin2

Huang, Z., Liu, J., Jin, J., Chen, Q., Shields, L. B. E., Zhang, Y., Shields, C. B., Zhou, L., Zhou, B., & Yu, P. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112966 · Cited by 17

tec-1 kinase negatively regulates regenerative neurogenesis in planarians

Karge, A., Bonar, N. A., Wood, S., & Petersen, C. P. (2020) · eLife · doi:10.7554/elife.47293 · Cited by 18

Down‐regulation of long non‐coding RNA MEG3 promotes Schwann cell proliferation and migration and repairs sciatic nerve injury in rats

Ma, Y., Zhai, D., Zhang, W., Zhang, H., Dong, L., Zhou, Y., Feng, D., Zheng, Y., Wang, T., Mao, C., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15368 · Cited by 17

Non-Cell-Autonomous Regulation of Optic Nerve Regeneration by Amacrine Cells

Sergeeva, E. G., Rosenberg, P. A., & Benowitz, L. I. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.666798 · Cited by 18

Injury-induced Autophagy Delays Axonal Regeneration after Optic Nerve Damage in Adult Zebrafish

Beckers, A., Vanhunsel, S., Dyck, A. V., Bergmans, S., Masin, L., & Moons, L. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.07.009 · Cited by 17

Electronic bypass of spinal lesions: activation of lower motor neurons directly driven by cortical neural signals

Li, Y., Alam, M., Guo, S., Ting, K. H., & He, J. (2014) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-11-107 · Cited by 17

Mild Hypothermia Promotes Pericontusion Neuronal Sprouting via Suppressing Suppressor of Cytokine Signaling 3 Expression after Moderate Traumatic Brain Injury

Zhao, C.-C., Wang, C., Li, W.-P., Lin, Y., Tang, Q., Feng, J., Mao, Q., Gao, G., & Jiang, J. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4759 · Cited by 17

P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush.

Oku, H., Morishita, S., Horie, T., Kida, T., Mimura, M., Kojima, S., & Ikeda, T. (2017) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.17-22179 · Cited by 17

Sphingosine 1-Phosphate Receptor 1 Modulates CNTF-Induced Axonal Growth and Neuroprotection in the Mouse Visual System

Joly, S., Dalkara, D., & Pernet, V. (2017) · Neural Plasticity · doi:10.1155/2017/6818970 · Cited by 17

PTEN knockdown with the Y444F mutant AAV2 vector promotes axonal regeneration in the adult optic nerve

Liu, Q., Huang, Z., Chen, H., Hu, Z., & Xie, P. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.224381 · Cited by 19

Effects of long-term rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice

Fan, Y., Nan, F., Guo, B.-L., Liao, Y. S. J., Zhang, M., Guo, J. Z., Niu, B., Liang, Y., Yang, C., Zhang, Y., et al. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.002 · Cited by 17

Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway

Ma, Y., Chen, H.-Y., Wei, Q.-S., Peng, L., Zhang, K.-J., Deng, Q., Wang, L., Liu, Z., Lai, B., Ding, Y., et al. (2025) · Neurospine · doi:10.14245/ns.2449312.656 · Cited by 16

3D‐Printing of Electroconductive MXene‐Based Micro‐Meshes in a Biomimetic Hyaluronic Acid‐Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications

Woods, I., Spurling, D., Sunil, S., O'Callaghan, A. M., Maughan, J., Gonzalez, J. G., McGuire, T. K., Leahy, L. M., Dervan, A. G., Nicolosi, V., et al. (2025) · Advanced Science · doi:10.1002/advs.202503454 · Cited by 16

Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures

Campion, T., Sheikh, I. S., Smit, R. D., Iffland, P. H., Chen, J., Junker, I. P., Krynska, B., Crino, P. B., & Smith, G. M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113961 · Cited by 15

Identification of a Novel Axon Regeneration Role for Noncanonical Wnt Signaling in the Adult Retina after Injury

Musada, G. R., Carmy, T., & Hackam, A. S. (2022) · eNeuro · doi:10.1523/eneuro.0182-22.2022 · Cited by 16

Experimental upregulation of developmentally downregulated ribosomal protein large subunits 7 and 7A promotes axon regeneration after injury in vivo

Xing, J., Theune, W. C., Łukomska, A., Frost, M. P., Damania, A., & Trakhtenberg, E. F. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114510 · Cited by 17

Individualized bio-scaffold encapsulating siPTEN-loaded exosomes for promoting neuronal regeneration in spinal cord injury

Shang, Z., Liu, Z., Han, M. H., Fan, H., Lu, D., Zhou, Z., Wang, Z., Li, Y., Wang, X., Wang, B., et al. (2023) · Composites Part B Engineering · doi:10.1016/j.compositesb.2023.111146 · Cited by 16

Trophic responsiveness of purified postnatal and adult rat retinal ganglion cells

Ma, C. H. E., & Taylor, J. S. H. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0897-4 · Cited by 16

Cyclin-Dependent Kinase 5 in Axon Growth and Regeneration

Ye, T., Fu, A. K. Y., & Ip, N. Y. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-398309-1.00006-8 · Cited by 17

Retinal regeneration mechanisms linked to multiple cancer molecules: A therapeutic conundrum

Barber, A. C., Farmer, K., Martin, K. R. G., & Smith, P. D. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.08.003 · Cited by 15

The application of CRISPR technology to high content screening in primary neurons

Callif, B. L., Maunze, B., Krueger, N. L., Simpson, M. T., & Blackmore, M. G. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.01.003 · Cited by 17

Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons

Rodriguez, L., Mdzomba, J. B., Joly, S., Boudreau-Laprise, M., Planel, E., & Pernet, V. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00293 · Cited by 16

Chromatin modification and epigenetic control in functional nerve regeneration

Berry, K., & Lu, Q. R. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.07.009 · Cited by 17

Roles of Non-coding RNAs in Central Nervous System Axon Regeneration

Li, P., Jia, Y., Tang, W., Cui, Q., Liu, M., & Jiang, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.630633 · Cited by 17

Developmentally upregulated transcriptional elongation factor a like 3 suppresses axon regeneration after optic nerve injury

Łukomska, A., Kim, J., Rheaume, B. A., Xing, J., Hoyt, A. C., Lecky, E., Steidl, T., & Trakhtenberg, E. F. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136260 · Cited by 16

MicroRNA-26a overexpression protects RGC-5 cells against H2O2-induced apoptosis

Kang, Y. E., Jia, P., Zhao, H., Hu, C., & Yang, X. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.164 · Cited by 16

Neurotrophic Effects of Serum- and Glucocorticoid-Inducible Kinase on Adult Murine Mesencephalic Dopamine Neurons

Chen, X. M., Tagliaferro, P. A., Kareva, T., Yarygina, O., Kholodilov, N. G., & Burke, R. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5910-11.2012 · Cited by 16

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration

Kuboyama, T., Luo, X., Park, K. K., Blackmore, M. G., Tojima, T., Tohda, C., Bixby, J. L., Lemmon, V., & Kamiguchi, H. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.06.011 · Cited by 17

Expression of PirB Protein in Intact and Injured Optic Nerve and Retina of Mice

Cai, X., Yuan, R., Hu, Z., Chen, C.-L., Yu, J., Zheng, Z., & Ye, J. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0656-2 · Cited by 16

Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve

Gresle, M. M., Liu, Y., Kilpatrick, T. J., Kemper, D., Wu, Q., Hu, B., Fu, Q., So, K., Sheng, G., Huang, G., et al. (2016) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217316641704 · Cited by 16

Rheb in neuronal degeneration, regeneration, and connectivity

Potheraveedu, V. N., Schöpel, M., Stoll, R., & Heumann, R. (2017) · Biological Chemistry · doi:10.1515/hsz-2016-0312 · Cited by 18

The Application of Omics Technologies to Study Axon Regeneration and CNS Repair

Tedeschi, A., & Popovich, P. G. (2019) · F1000Research · doi:10.12688/f1000research.17084.1 · Cited by 16

Traditional two-dimensional mesenchymal stem cells (MSCs) are better than spheroid MSCs on promoting retinal ganglion cells survival and axon regeneration

Huang, W. C., Wang, C., Xie, L., Wang, X., Zhang, L., Chen, C., & Jiang, B. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107699 · Cited by 20

Novel Influences of Sex andAPOEGenotype on Spinal Plasticity and Recovery of Function after Spinal Cord Injury

Strattan, L. E., Britsch, D. R. S., Calulot, C. M., Maggard, R. S. J., Abner, E. L., Johnson, L. A., & Alilain, W. J. (2021) · eNeuro · doi:10.1523/eneuro.0464-20.2021 · Cited by 17

How Brain Arousal Mechanisms Work

Pfaff, D. W. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108377485 · Cited by 22

Dendrite pathology and neurodegeneration: focus on mTOR

Polo, A. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.155421 · Cited by 16

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Yang, S., Li, C., Wang, X., Huang, T., Qian, C., Li, Q., Zhao, L., Zhou, S., Ding, C., Nie, R., et al. (2025) · Advanced Science · doi:10.1002/advs.202405537 · Cited by 15

Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the activation of neural stem progenitor cells

Peñailillo, J., Palacios, M., Mounieres, C., Muñoz, R., Slater, P. G., Domenico, E. D., Patrushev, I., Gilchrist, M. J., & Larraı́n, J. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00179-3 · Cited by 15

Regenerative Potential of Injured Spinal Cord in the Light of Epigenetic Regulation and Modulation

Gupta, S., Dutta, S., & Hui, S. P. (2023) · Cells · doi:10.3390/cells12131694 · Cited by 17

Inflammatory Mediators of Axon Regeneration in the Central and Peripheral Nervous Systems

Benowitz, L. I., Xie, L., & Yin, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015359 · Cited by 15

An effective pharmacological hydrogel induces optic nerve repair and improves visual function

Wang, L., Zhang, S., Han, Y., Tang, S., Li, J., Bu, L., Zhao, D., & Deng, H. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2394-3 · Cited by 15

Glycogen synthase kinase 3 signaling in neural regeneration in vivo

Zhang, J., Yang, S., & Zhou, F. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad075 · Cited by 18

Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies

Mamun, A. A., Zhou, Q., Geng, P., Wang, S., Shao, C., & Xiao, J. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70193 · Cited by 15

Neural Regeneration: Lessons from Regenerating and Non-regenerating Systems

Ferreira, L. M. R., Floriddia, E. M., Quadrato, G., & Giovanni, S. D. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8290-9 · Cited by 17

A Microchip for High-Throughput Axon Growth Drug Screening

Kim, H. J., Jeong, S., Koo, C., Han, A., & Park, J. (2016) · Micromachines · doi:10.3390/mi7070114 · Cited by 15

Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI

Urban, M. W., Ghosh, B., Strojny, L. R., Block, C. G., Blazejewski, S. M., Wright, M. C., Smith, G. M., & Lepore, A. C. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.02.007 · Cited by 15

RNA sequencing profiling of the retina in C57BL/6J and DBA/2J mice: Enhancing the retinal microarray data sets from GeneNetwork.

Wang, J., Geisert, E. E., & Struebing, F. L. (2019) · PubMed Central · doi:10.60944/dzne-2020-07116 · Cited by 15

Comparative gene expression profiling between optic nerve and spinal cord injury in Xenopus laevis reveals a core set of genes inherent in successful regeneration of vertebrate central nervous system axons

Belrose, J. L., Prasad, A., Sammons, M. A., Gibbs, K. M., & Szaro, B. G. (2020) · BMC Genomics · doi:10.1186/s12864-020-06954-8 · Cited by 15

Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury

Kwon, H.-S., Kevala, K., Hu, X., Patnaik, S., Marugán, J., & Kim, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073386 · Cited by 15

Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury

zu Reckendorf, C. M., Moser, D., Blechschmidt, A., Joga, V. N., Sinske, D., Hegler, J., Deininger, S., Catanese, A., Vettorazzi, S., Antoniadis, G., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1305-21.2022 · Cited by 15

Intermittent hypoxia training after C2 hemisection modifies the expression of PTEN and mTOR

Gutierrez, D. V., Clark, M., Nwanna, O., & Alilain, W. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.013 · Cited by 15

Oestradiol signalling through the Akt–mTORC1–S6K1

Varea, O., Escoll, M., Díez, H., Garrido, J. J., & Wandosell, F. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.12.019 · Cited by 15

Expression of MicroRNA-29a Regulated by Yes-Associated Protein Modulates the Neurite Outgrowth in N2a Cells

Tan, C., Yu, C.-L., Song, Z., Zou, H., Xu, X., & Liu, J. (2017) · BioMed Research International · doi:10.1155/2017/5251236 · Cited by 15

Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat

Carlin, D., Golden, J. P., Mogha, A., Samineni, V. K., Monk, K. R., Gereau, R. W., & Cavalli, V. (2018) · eNeuro · doi:10.1523/eneuro.0436-17.2018 · Cited by 15

Effects of siRNA-Mediated Knockdown of GSK3β on Retinal Ganglion Cell Survival and Neurite/Axon Growth

Ahmed, Z., Morgan-Warren, P. J., Berry, M., Scott, R. A. H., & Logan, A. (2019) · Cells · doi:10.3390/cells8090956 · Cited by 13

Nipradilol Promotes Axon Regeneration Through S-Nitrosylation of PTEN in Retinal Ganglion Cells

Koriyama, Y., Kamiya, M., Arai, K., Sugitani, K., Ogai, K., & Kato, S. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3209-8_94 · Cited by 15

Advances and Challenges for Neural Regeneration Research

Wang, X., So, K., & Xu, X. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801732-6.00001-x · Cited by 16

Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

Leibinger, M., Zeitler, C., Paulat, M., Gobrecht, P., Hilla, A. M., Andreadaki, A., Guthoff, R., & Fischer, D. (2023) · eLife · doi:10.7554/elife.88279 · Cited by 20

CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model

Yu, H., Shen, B., Han, R., Zhang, Y., Xu, S., Zhang, Y., Guo, Y., Huang, P., Huang, S., & Zhong, Y. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00343-4 · Cited by 15

Electric field stimulation directs target-specific axon regeneration and partial restoration of vision after optic nerve crush injury

Kim, T., Iseri, E., Peng, M. G., Medvidovic, S., Silliman, T., Pahlavan, P., Niu, G., Huang, C. Y., Simonyan, A., Pahnahad, J., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0315562 · Cited by 16

Cross Talk between Cellular Redox Status, Metabolism, and p53 in Neural Stem Cell Biology

Forsberg, K., & Giovanni, S. D. (2014) · The Neuroscientist · doi:10.1177/1073858413514634 · Cited by 14

Clinical Considerations for Vascularized Composite Allotransplantation of the Eye

Davidson, E. H., Wang, E. W., Yu, J. Y., Fernandez-Miranda, J. C., Wang, D. J., Li, Y., Miller, M. R., Sivak, W. N., Bourne, D., Wang, H., et al. (2016) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000002985 · Cited by 14

Maximizing functional axon repair in the injured central nervous system: Lessons from neuronal development

Kaplan, A., Bueno, M., Hua, L., & Fournier, A. E. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24536 · Cited by 15

Effect of Triptolide on retinal ganglion cell survival in an optic nerve crush model

Li, Y.-F., Zou, Y.-F., Chen, X., & Zhang, W. (2017) · Cellular and Molecular Biology · doi:10.14715/cmb/2017.63.5.19 · Cited by 14

Activation of the Akt/mTOR signaling pathway: A potential response to long-term neuronal loss in the hippocampus after sepsis

Tian, L., Zhou, D., Guo, J., Liu, W., & Mu, J. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.219044 · Cited by 14

Neural Cadherin Plays Distinct Roles for Neuronal Survival and Axon Growth under Different Regenerative Conditions

Ribeiro, M., Levay, K., Yon, B., Ayupe, A. C., Salgueiro, Y., & Park, K. K. (2020) · eNeuro · doi:10.1523/eneuro.0325-20.2020 · Cited by 14

Spinal cord regeneration — the origins of progenitor cells for functional rebuilding

Walker, S. E., & Echeverri, K. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101917 · Cited by 14

RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration

Zhou, X., Lv, Y., Xie, H., Li, Y., Liu, C., Zheng, M., Wu, R., Zhou, S., Gu, X., Li, J., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.387980 · Cited by 14

Preventive Effects of Rapamycin on Inflammation and Capillary Degeneration in a Rat Model of NMDA-Induced Retinal Injury

Aoki, Y., Nakahara, T., Asano, D., Ushikubo, H., Mori, A., Sakamoto, K., & Ishii, K. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00631 · Cited by 14

Virally delivered, constitutively active NF κB improves survival of injured retinal ganglion cells

Dvoriantchikova, G., Pappas, S., Luo, X., Ribeiro, M., Danek, D. J., Pelaez, D., Park, K. K., & Ivanov, D. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13383 · Cited by 14

Intrathecal Delivery of IL-6 Reactivates the Intrinsic Growth Capacity of Pyramidal Cells in the Sensorimotor Cortex after Spinal Cord Injury

Yang, P., Qin, Y., Bian, C., Zhao, Y., & Zhang, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127772 · Cited by 14

Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt/mTOR pathway and regulating BDNF and PTEN expression.

Zhu, H., Wang, Y., Yang, X. Q., Wan, G., Qiu, Y., Ye, X., Gao, Y., & Wan, D. (2019) · Europe PMC (PubMed Central) · Cited by 14

Designing neuroreparative strategies using aged regenerating animal models

Vanhunsel, S., Beckers, A. M., & Moons, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101086 · Cited by 14

Respiratory plasticity following spinal cord injury: perspectives from mouse to man

Locke, K. C., Randelman, M. L., Hoh, D. J., Zholudeva, L. V., & Lane, M. A. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335839 · Cited by 14

New Insights into TETs in Psychiatric Disorders

Zhan, W., Li, Y., Yuan, J., Zhi, N., Huang, Y., Liu, Y., Zhang, M., Wu, S., & Zhao, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094909 · Cited by 14

Modification of autophagy-lysosomal pathway as a neuroprotective treatment for spinal cord injury

Lipinski, M. M., & Wu, J. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.158344 · Cited by 14

No simpler than mammals: axon and dendrite regeneration in Drosophila: Figure 1.Preprint

Nawabi, H., Zukor, K., & He, Z. (2012) · Genes & Development · doi:10.1101/gad.198150.112 · Cited by 14

Advances in mesenchymal stem cells and their derivatives for promoting peripheral nerve regeneration

Wei, S., Dong, J., Hu, Q., Bai, J., Gao, X., Shan, H., Sheng, L., Dai, J., Tao, L., Yan, B., et al. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf027 · Cited by 14

Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury

Wang, K., Chen, X., Liu, M., Li, Y., Zhu, Y., Zhou, T., Tao, W., Ma, Y., Guo, Y., Wang, L., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06611-2 · Cited by 13

Multichannel 3D-Printed Bioactive Scaffold Combined with Small Interfering RNA Delivery to Promote Neurological Recovery after Spinal Cord Injury

Ye, J., Li, F., Wen, Z., He, J., Pan, G., Zhai, X., Song, L., Zhang, X., Zhou, X., Yao, X., et al. (2025) · Research · doi:10.34133/research.0951 · Cited by 15

Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling

Golan, N., Ehrlich, D. B., Bonanno, J., O’Brien, R., Murillo, M., Kauer, S. D., Ravindra, N. G., van Dijk, D., & Cafferty, W. B. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0811-22.2023 · Cited by 17

PTEN deletion in spinal pathways via retrograde transduction with AAV-RG enhances forelimb motor recovery after cervical spinal cord injury; Sex differences and late-onset pathophysiologies

Metcalfe, M., & Steward, O. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114551 · Cited by 12

Intrinsic control of axon regeneration

He, Z. (2010) · The FASEB Journal · doi:10.1096/fasebj.24.1_supplement.173.3

Novel mechanisms to stimulate regrowth

Flight, M. H. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2556

Modulation of the PTEN/mTOR Pathway Promoting Axon Regeneration in the Adult CNS by

Park, K. K. (2009)

Axon guidance in regeneration of the mature central nervous system: step by step

Schaeffer, J., Vilallongue, N., Belin, S., & Nawabi, H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.373663 · Cited by 13

Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration

Huang, H., Kaur, S., & Hu, Y. (2019) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-190949 · Cited by 10