Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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Defining the role of mTOR in cancer

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The Biology of Cancer

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Glial inhibition of CNS axon regeneration

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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Targeting the PI3K-Akt pathway in human cancer

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Degeneration and regeneration of axons in the lesioned spinal cord

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

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Full-length optic nerve regeneration in the absence of genetic manipulations

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Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO‐1 but induce an interferon response and cytotoxicity in central nervous system neurones

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AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth

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Intrinsic Mechanisms Regulating Axon Regeneration

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Expressing Constitutively Active Rheb in Adult Dorsal Root Ganglion Neurons Enhances the Integration of Sensory Axons that Regenerate Across a Chondroitinase-Treated Dorsal Root Entry Zone Following Dorsal Root Crush

Wu, D., Klaw, M. C., Kholodilov, N. G., Burke, R. E., Detloff, M. R., Côté, M., & Tom, V. J. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00049 · Cited by 22

PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

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Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration

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Assembly and repair of eye-to-brain connections

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Spatiotemporal distribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents

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Viral vectors for neuronal cell type-specific visualization and manipulations

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Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals

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The Mechanisms of Peripheral Nerve Preconditioning Injury on Promoting Axonal Regeneration

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NB‐3 signaling mediates the cross‐talk between post‐traumatic spinal axons and scar‐forming cells

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Factors governing the transduction efficiency of adeno-associated virus in the retinal ganglion cells following intravitreal injection

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Regenerative medicine approaches for the treatment of spinal cord injuries: Progress and challenges

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PTEN Blocking Stimulates Corticospinal and Raphespinal Axonal Regeneration and Promotes Functional Recovery After Spinal Cord Injury

Bhowmick, S., & Muneer, P. M. A. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa147 · Cited by 21

Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration

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Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke

Tsang, C. K., Mi, Q.-J., Su, G., Lee, G. H., Xie, X., D’Arcangelo, G., Huang, L., & Zheng, X. F. S. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.11.007 · Cited by 21

Post-injury born oligodendrocytes incorporate into the glial scar and contribute to the inhibition of axon regeneration

Xing, J., Rheaume, B. A., Kim, J., Łukomska, A., Sajid, M. S., Damania, A., & Trakhtenberg, E. F. (2023) · Development · doi:10.1242/dev.201311 · Cited by 22

Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice

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The role of TSC1 and TSC2 proteins in neuronal axons

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Surviving mossy cells enlarge and receive more excitatory synaptic input in a mouse model of temporal lobe epilepsy

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Traumatology of the optic nerve and contribution of crystallins to axonal regeneration

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C. elegans as a genetic model to identify novel cellular and molecular mechanisms underlying nervous system regeneration

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Collaborative Models for Translational Neuroscience and Rehabilitation Research

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Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation

Jin, E., Ko, H. R., Hwang, I., Kim, B.-S., Choi, J., Park, K. W., Cho, S., & Ahn, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-20755-w · Cited by 22

Nogo-A inactivation improves visual plasticity and recovery after retinal injury

Mdzomba, J. B., Jordi, N., Rodriguez, L., Joly, S., Bretzner, F., & Pernet, V. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0780-x · Cited by 21

Long-Distance Axon Regeneration Promotes Recovery of Diaphragmatic Respiratory Function after Spinal Cord Injury

Urban, M. W., Ghosh, B., Block, C. G., Strojny, L. R., Charsar, B. A., Goulão, M., Komaravolu, S., Smith, G. M., Wright, M. C., Li, S., et al. (2019) · eNeuro · doi:10.1523/eneuro.0096-19.2019 · Cited by 23

Acupuncture Treatment Reverses Retinal Gene Expression Induced by Optic Nerve Injury via RNA Sequencing Analysis

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mTORC1 and mTORC2 expression in inner retinal neurons and glial cells

Losiewicz, M. K., Elghazi, L., Fingar, D. C., Rajala, R. V. S., Lentz, S. I., Fort, P. E., Abcouwer, S. F., & Gardner, T. W. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108131 · Cited by 20

Intrinsic control of axon regeneration

He, Z. (2010) · Journal of Biomedical Research · doi:10.1016/s1674-8301(10)60002-4 · Cited by 21

The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regenerationPreprint

Vargas, E. J. M., Matamoros, A. J., Qiu, J., Jan, C. H., Wang, Q., Gorczyca, D., Han, T. W., Weissman, J. S., Jan, L. Y., Banerjee, S., et al. (2020) · Genes & Development · doi:10.1101/gad.331330.119 · Cited by 20

Traumatic spinal cord injury: a review of the current state of art and future directions – what do we know and where are we going?

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Aspects of ocular war injuries

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Panax notoginseng Saponins Stimulates Neurogenesis and Neurological Restoration After Microsphere-Induced Cerebral Embolism in Rats Partially Via mTOR Signaling

Gao, J., Liu, J., Yao, M., Zhang, W., Yang, B., & Wang, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.889404 · Cited by 20

Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system

Han, X., Xu, J., Chen, Z., Li, P., Zhao, L., Tao, J., Yu, S., Zhu, S., Yu, B., Zhu, J., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114157 · Cited by 20

Unleashing Intrinsic Growth Pathways in Regenerating Peripheral Neurons

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Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach

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Optic Nerve Regeneration in Diabetic Retinopathy: Potentials and Challenges Ahead

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Epigenetic and epitranscriptomic regulation of axon regeneration

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Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2

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Postsynaptic neuronal activity promotes regeneration of retinal axons

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Umbilical cord mesenchymal stem cell‐derived exosomes promote axon regeneration during optic nerve injury through microRNA‐dependent mTORC1 signalling

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PTEN knockout using retrogradely transported AAVs transiently restores locomotor abilities in both acute and chronic spinal cord injury

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The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons

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Adeno-associated virus vectors for retinal gene therapy in basic research and clinical studies

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Sirt6 protects retinal ganglion cells and optic nerve from degeneration during aging and glaucoma

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Neurites regrowth of cortical neurons by GSK3β inhibition independently of Nogo receptor 1

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C. elegans as a model to study PTEN’s regulation and function

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Activation of CNTF/CNTFRα Signaling Pathway by hRheb(S16H) Transduction of Dopaminergic Neurons In Vivo

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PTEN plasticity: how the taming of a lethal gene can go too far

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Frontiers Of Spinal Cord And Spine Repair: Experimental Approaches for Repair of Spinal Cord Injury

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Nogo-A in the visual system development and in ocular diseases

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Phosphatase and tensin homologue: a therapeutic target for SMA

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BMP4/Smad1 Signalling Promotes Spinal Dorsal Column Axon Regeneration and Functional Recovery After Injury

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The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons

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Signaling roles of phosphoinositides in the retina

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Diabetic polyneuropathy: Bridging the translational gap

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Optogenetic Modulation of Neural Progenitor Cells Improves Neuroregenerative Potential

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The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease

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Reactivation of the PI3K/Akt Signaling Pathway by the Bisperoxovanadium Compound bpV(pic) Attenuates Photoreceptor Apoptosis in Experimental Retinal Detachment

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Striking the balance between PTEN and PDK1: it all depends on the cell context: Figure 1.Preprint

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Ca 2+ /Calmodulin-Dependent Protein Kinase II Enhances Retinal Ganglion Cell Survival But Suppresses Axon Regeneration after Optic Nerve Injury

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Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration

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The intracellular domain of L1 CAM binds to casein kinase 2α and is neuroprotective via inhibition of the tumor suppressors PTEN and p53

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A New Functional Role for Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) in the Circadian Regulation of L-Type Voltage-Gated Calcium Channels in Avian Cone Photoreceptors

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

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Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

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Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent

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Gliotransmission and adenosine signaling promote axon regeneration

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Optic nerve regeneration: Potential treatment approaches

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Axonal Regeneration after Spinal Cord Injury: Molecular Mechanisms, Regulatory Pathways, and Novel Strategies

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Combinatorial treatment of acute spinal cord injury with ghrelin, ibuprofen, C16, and ketogenic diet does not result in improved histologic or functional outcome

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Axon growth and guidance

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Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury

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Heterogeneity in the regenerative abilities of central nervous system axons within species: why do some neurons regenerate better than others?

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Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury

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Involvement of EphB/Ephrin-B Signaling in Axonal Survival in Mouse Experimental Glaucoma

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Ptena, but not Ptenb, reduces regeneration after spinal cord injury in adult zebrafish

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PTEN: A molecular target for neurodegenerative disorders

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Immunoproteasome Deficiency Protects in the Retina after Optic Nerve Crush

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Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole‐rats

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White matter lesions contribute to motor and non-motor disorders in Parkinson’s disease: a critical review

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Reversing Persistent PTEN Activation after Traumatic Brain Injury Fuels Long‐Term Axonal Regeneration via Akt/mTORC1 Signaling Cascade

Shi, Z., Mao, L., Chen, S., Du, Z., Xiang, J., Shi, M., Wang, Y., Wang, Y., Chen, X., Xu, H., et al. (2024) · Advanced Science · doi:10.1002/advs.202410136 · Cited by 20

In vivo evaluation of retinal ganglion cells and optic nerve's integrity in large animals by multi-modality analysis

Zhang, Y., Zhang, S., Xia, Y., Ji, Y., Jiang, W., Li, M., Huang, H., Xu, M., Sun, J., Ye, Q., et al. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108117 · Cited by 18

Scrap and Build for Functional Neural Circuits: Spatiotemporal Regulation of Dendrite Degeneration and Regeneration in Neural Development and Disease

Furusawa, K., & Emoto, K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.613320 · Cited by 19

Human Pluripotent Stem Cell-Derived Neural Progenitor Cells Promote Retinal Ganglion Cell Survival and Axon Recovery in an Optic Nerve Compression Animal Model

Park, M., Kim, H., Shin, H. A., Lee, S., Hwang, D., & Lew, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212529 · Cited by 18

Neurobiological Opportunities in Diabetic Polyneuropathy

Poitras, T. M., Munchrath, E., & Zochodne, D. W. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01138-y · Cited by 19

Maf1 regulates axonal regeneration of retinal ganglion cells after injury

Chen, D., Sun, Y., Zhou, L.-Y., Yang, S., Hong, F.-Y., Liu, X., Sun, Z.-L., Huang, J., & Feng, D. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113948 · Cited by 18

CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice

Ye, M., Huang, J., Mou, Q., Luo, J., Hu, Y., Lou, X., Yao, K., Zhao, B., Duan, Q., Li, X., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04445-6 · Cited by 19

Intrinsic regulation of axon regeneration after spinal cord injury: Recent advances and remaining challenges

Noristani, H. N. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114198 · Cited by 18

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons

Halawani, D., Wang, Y., Ramakrishnan, A., Estill, M. S., He, X., Shen, L., Friedel, R. H., & Zou, H. (2023) · Nature Communications · doi:10.1038/s41467-023-40816-7 · Cited by 20

Augmenting fibronectin levels in injured adult CNS promotes axon regeneration in vivo

Łukomska, A., Rheaume, B. A., Frost, M. P., Theune, W. C., Xing, J., Damania, A., & Trakhtenberg, E. F. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114877 · Cited by 17

Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury

Chen, W., Wu, J., Yang, C., Li, S., Liu, Z., An, Y., Wang, X., Cao, J., Xu, J., Duan, Y., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404395121 · Cited by 19

Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction

Huang, K.-C., Gomes, C., Shiga, Y., Belforte, N., VanderWall, K. B., Lavekar, S. S., Fligor, C. M., Harkin, J., Hetzer, S. M., Patil, S., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01872-2 · Cited by 18

Axonal protection by modulation of p62 expression in TNF-induced optic nerve degeneration

Kojima, K., Kitaoka, Y., Munemasa, Y., Hirano, A., Sase, K., & Takagi, H. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.08.021 · Cited by 18

Protection of Pattern Electroretinogram and Retinal Ganglion Cells by Oncostatin M after Optic Nerve Injury

Xia, X., Wen, R., Chou, T.-H., Li, Y., Wang, Z., & Porciatti, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108524 · Cited by 18

tPA promotes cortical neuron survival via mTOR-dependent mechanisms

Grummisch, J. A., Jadavji, N. M., & Smith, P. D. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.03.005 · Cited by 17

A Drosophila In Vivo Injury Model for Studying Neuroregeneration in the Peripheral and Central Nervous System

Li, D., Li, F., Guttipatti, P., & Song, Y. (2018) · Journal of Visualized Experiments · doi:10.3791/57557 · Cited by 18

Intrinsic control of axon regeneration

He, Z. (2010) · The FASEB Journal · doi:10.1096/fasebj.24.1_supplement.173.3

Novel mechanisms to stimulate regrowth

Flight, M. H. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2556

Modulation of the PTEN/mTOR Pathway Promoting Axon Regeneration in the Adult CNS by

Park, K. K. (2009)

Axon guidance in regeneration of the mature central nervous system: step by step

Schaeffer, J., Vilallongue, N., Belin, S., & Nawabi, H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.373663 · Cited by 13

Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration

Huang, H., Kaur, S., & Hu, Y. (2019) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-190949 · Cited by 10