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Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast
Open accessAbstract
An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe , by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery ( rsh1 ) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.
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“It is clear that the digenic interactions we have mapped in yeast can be conserved in different yeast species over hundreds of millions of years of evolution (49, 50).”
From A global genetic interaction network maps a wiring diagram of cellular function (2016) · cites this paper as [50]
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Metadata
- Authors
- Roguev, A., Bandyopadhyay, S., Zofall, M., Zhang, K., Fischer, T., Collins, S. R., Qu, H., Shales, M., Park, H.-O., Hayles, J., Hoe, K.-L., Kim, D.-U., Ideker, T., Grewal, S. I., Weissman, J. S., & Krogan, N. J.
- Affiliations
- QB3 (US)
- Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
- Corresponding author
- Ideker, Trey
- Grewal, Shiv I.
- Weissman, Jonathan S.
- Krogan, Nevan J.
- ORCID
- Venue
- Science
- Published
- 2008-10-17
- Volume
- 322
- Issue
- 5900
- Pages
- 405-410
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2753251
- OpenAlex
- W2048233403
- Cited by
- 352
- References
- 40
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 12 · 2017: 33 · 2016: 18 · 2015: 28 · 2014: 26 · 2013: 32 · 2012: 38
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- KRIBB Repository (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM084279, GM084279)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- Schizosaccharomyces pombe, genetic interactions, functional modules, protein complexes, RNA interference, transcriptional regulation, DNA repair, DNA replication
- MeSH terms
- DNA Repair, DNA Replication, Epistasis, Genetic, Genes, Fungal, Histones, Mutation, Saccharomyces cerevisiae, Schizosaccharomyces, Gene Expression Regulation, Fungal, Schizosaccharomyces pombe Proteins, RNA Interference, Gene Regulatory Networks
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