The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast
Open accessAbstract
An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe , by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery ( rsh1 ) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is clear that the digenic interactions we have mapped in yeast can be conserved in different yeast species over hundreds of millions of years of evolution (49, 50).”
From A global genetic interaction network maps a wiring diagram of cellular function (2016) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, A., Böesche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A., Cruciat, C., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,729
BioGRID: a general repository for interaction datasets
Stark, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj109 · Cited by 3,960
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Krogan, N. J., Cagney, G., Yu, H., Zhong, G., Guo, X., Ignatchenko, A., Li, J., Pu, S., Datta, N., Tikuisis, A., et al. (2006) · Nature · doi:10.1038/nature04670 · Cited by 2,969
Self-citationGlobal Mapping of the Yeast Genetic Interaction Network
Tong, A. H. Y., Lesage, G., Bader, G. D., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G. F., Brost, R. L., Chang, M., et al. (2004) · Science · doi:10.1126/science.1091317 · Cited by 2,089
Self-citationATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex
Mizuguchi, G., Shen, X., Landry, J., Wu, W.-H., Sen, S., & Wu, C. (2003) · Science · doi:10.1126/science.1090701 · Cited by 1,312
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
Self-citationSchuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870
Self-citationCollins, S. R., Miller, K. M., Maas, N. L., Roguev, A., Fillingham, J., Chu, C. S., Schuldiner, M., Gebbia, M., Recht, J., Shales, M., et al. (2007) · Nature · doi:10.1038/nature05649 · Cited by 869
Self-citationRoguev, A., Schaft, D., Shevchenko, A., Pijnappel, W. W. M. P., Wilm, M. S., Aasland, R., & Stewart, A. F. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7137 · Cited by 608
Self-citationKobor, M. S., Venkatasubrahmanyam, S., Meneghini, M. D., Gin, J., Jennings, J. L., Link, A. J., Madhani, H. D., & Rine, J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020131 · Cited by 607
Cited by
Sorted by citations
A global genetic interaction network maps a wiring diagram of cellular function
Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240
van Opijnen, T., Bodi, K. L., & Camilli, A. (2009) · Nature Methods · doi:10.1038/nmeth.1377 · Cited by 926
Structure and dynamics of molecular networks: A novel paradigm of drug discovery
Csermely, P., Korcsmáros, T., Kiss, H., London, G., & Nussinov, R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.016 · Cited by 911
Ideker, T., & Krogan, N. J. (2012) · Molecular Systems Biology · doi:10.1038/msb.2011.99 · Cited by 795
Self-citationAnalysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe
Kim, D.-U., Hayles, J., Kim, D., Wood, V., Park, H.-O., Won, M., Yoo, H.-S., Duhig, T., Nam, M., Palmer, G., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1628 · Cited by 742
Self-citation
Metadata
- Authors
- Roguev, A., Bandyopadhyay, S., Zofall, M., Zhang, K., Fischer, T., Collins, S. R., Qu, H., Shales, M., Park, H.-O., Hayles, J., Hoe, K.-L., Kim, D.-U., Ideker, T., Grewal, S. I., Weissman, J. S., & Krogan, N. J.
- Affiliations
- QB3 (US)
- Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
- Corresponding author
- Ideker, Trey
- Grewal, Shiv I.
- Weissman, Jonathan S.
- Krogan, Nevan J.
- ORCID
- Venue
- Science
- Published
- 2008-10-17
- Volume
- 322
- Issue
- 5900
- Pages
- 405-410
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2753251
- OpenAlex
- W2048233403
- Cited by
- 352
- References
- 40
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 12 · 2017: 33 · 2016: 18 · 2015: 28 · 2014: 26 · 2013: 32 · 2012: 38
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- KRIBB Repository (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM084279, GM084279)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- Schizosaccharomyces pombe, genetic interactions, functional modules, protein complexes, RNA interference, transcriptional regulation, DNA repair, DNA replication
- MeSH terms
- DNA Repair, DNA Replication, Epistasis, Genetic, Genes, Fungal, Histones, Mutation, Saccharomyces cerevisiae, Schizosaccharomyces, Gene Expression Regulation, Fungal, Schizosaccharomyces pombe Proteins, RNA Interference, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
