Metabolic coupling between glia and neurons
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Keywords: Cell Communication Reference LNDC-REVIEW-1996-002View record in PubMed Record created on 2010-01-08, modified on 2017-05-12
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Astrocytes play a crucial role in the flux of energy substrates to neurons by regulating the rate of glucose uptake and phosphorylation in response to glutamate concentrations in the synaptic cleft.
“Glial cells, particularly astrocytes, play a crucial role in the flux of energy substrates to neurons by regulating the rate of glucose uptake and phosphorylation in response to glutamate concentrations in the synaptic cleft (9).”
From Evolution of increased glia–neuron ratios in the human frontal cortex (2006) · cites this paper as [9]
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- Authors
- Tsacopoulos, M., & Magistretti, P.
- Affiliations
- University of Geneva (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1996-02-01
- Volume
- 16
- Issue
- 3
- Pages
- 877-885
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6578818
- OpenAlex
- W2139155172
- Cited by
- 1,006
- References
- 34
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 8 · 2023: 10 · 2022: 23 · 2021: 23 · 2020: 17 · 2019: 14 · 2018: 22 · 2017: 14 · 2016: 27 · 2015: 28 · 2014: 25 · 2013: 31 · 2012: 35
- FWCI
- 22.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- glial cells, neurons, intercellular communication, brain energy metabolism
- MeSH terms
- Alanine, Animals, Bees, Biological Transport, Capillary Permeability, Cell Communication, Cells, Cultured, Cerebral Cortex, Deoxyglucose, Energy Metabolism, Glycogen, Glycolysis, Guinea Pigs, Humans, Lactates, Male, Models, Biological, Synaptic Transmission, Neuroglia, Neurons, Retina, Tomography, Emission-Computed, Neurotransmitter Agents, Glutamic Acid, Mice
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