Cited by 3,130Congenital heart defects researchNeurogenesis and neuroplasticity mechanismsMesenchymal stem cell research

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

Evidence for Cardiomyocyte Renewal in Humans

Open access

Bergmann, Olaf, Bhardwaj, Ratan D., Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A., Druid, Henrik, Jovinge, Stefan, Frisén, Jonas·2009·Science

DOI 10.1126/science.1164680PMC PMC2991140

Open this paper in CoChat — free account

Abstract

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1164680

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357
Self-citation
Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction
Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S., Finato, N., Bussani, R., Nadal‐Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442303 · Cited by 1,426
Regenerating the heart
Laflamme, M. A., & Murry, C. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1117 · Cited by 967
Cardiac tumours: diagnosis and management
BUTANY, J. W., Nair, V., Naseemuddin, A., Nair, G. M., Catton, C., & Yau, T. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70093-0 · Cited by 846
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
Hsieh, P. C. H., Segers, V. F. M., Davis, M. E., MacGillivray, C., Gannon, J., Molkentin, J. D., Robbins, J. M., & Lee, R. T. (2007) · Nature Medicine · doi:10.1038/nm1618 · Cited by 778
Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.
Olivetti, G., Melissari, M., Capasso, J. M., & Anversa, P. (1991) · Circulation Research · doi:10.1161/01.res.68.6.1560 · Cited by 774
Retrospective Birth Dating of Cells in Humans
Spalding, K. L., Bhardwaj, R. D., Buchholz, B. A., Druid, H., & Frisén, J. (2005) · Cell · doi:10.1016/j.cell.2005.04.028 · Cited by 649
Self-citation
Survey of Studies Examining Mammalian Cardiomyocyte DNA Synthesis
Soonpaa, M. H., & Field, L. J. (1998) · Circulation Research · doi:10.1161/01.res.83.1.15 · Cited by 558
Stem-cell-based therapy and lessons from the heart
Passier, R. C., Laake, L. W. V., & Mummery, C. L. (2008) · Nature · doi:10.1038/nature07040 · Cited by 528
The Tropospheric 14CO2 Level in Mid-Latitudes of the Northern Hemisphere (1959–2003)
Levin, I., & Kromer, B. (2004) · Radiocarbon · doi:10.1017/s0033822200033130 · Cited by 527

Flagged first, then by citations

Show all 29 references

1 of the 29 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

V. Brodsky, D. S. Sarkisov, A. M. Arefyeva, N. W. Panova, I. G. Gvasava, Virchows Arch.424, 429 (1994).
P. Pfitzer, Curr. Top. Pathol.54, 125 (1971).

Sorted by citations

Items 301–400 of 1,006

Strategies for Cardiac Regeneration and Repair
Lin, Z., & Pu, W. T. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3006681 · Cited by 131
Molecular effects of exercise training in patients with cardiovascular disease: focus on skeletal muscle, endothelium, and myocardium
Adams, V., Reich, B., Uhlemann, M., & Niebauer, J. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00470.2016 · Cited by 131
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
Thienpont, B., Aronsen, J. M., Robinson, E. L., Okkenhaug, H., Loche, E., Ferrini, A., Brien, P., Alkass, K., Tomasso, A., Agrawal, A., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88353 · Cited by 125
Self-citation
Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism
Zhao, L., Ben-Yair, R., Burns, C. E., & Burns, C. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.048 · Cited by 128
New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart
Ikeda, Y., Sciarretta, S., Nagarajan, N., Rubattu, S., Volpe, M., Frati, G., & Sadoshima, J. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/210934 · Cited by 126
Periostin in cardiovascular disease and development: a tale of two distinct roles
Landry, N. M., Cohen, S., & Dixon, I. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0659-5 · Cited by 124
Wnt/β-catenin signaling in heart regeneration
Özhan, G., & Weidinger, G. (2015) · Cell Regeneration · doi:10.1186/s13619-015-0017-8 · Cited by 125
Development, Proliferation, and Growth of the Mammalian Heart
Günthel, M., Barnett, P., & Christoffels, V. M. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.022 · Cited by 129
Stem cell therapy for cardiac disease
Bernstein, H. S., & Srivastava, D. (2012) · Pediatric Research · doi:10.1038/pr.2011.61 · Cited by 121
Myocardial infarction: a critical role of macrophages in cardiac remodeling
Weinberger, T., & Schulz, C. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00107 · Cited by 125
Protein Therapeutics for Cardiac Regeneration after Myocardial Infarction
Segers, V. F. M., & Lee, R. T. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9207-5 · Cited by 121
High-sensitive cardiac troponin T.
Xu, R., Zhu, X.-F., Yang, Y., & Ye, P. (2013) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1671-5411.2013.01.015 · Cited by 127
Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity
Abad, M., Hashimoto, H., Zhou, H., Morales, M. G., Chen, B., Bassel‐Duby, R., & Olson, E. N. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.01.025 · Cited by 120
Electrospun nanofibrous membrane for biomedical application
Yan, B., Zhang, Y., Li, Z., Zhou, P., & Mao, Y. (2022) · SN Applied Sciences · doi:10.1007/s42452-022-05056-2 · Cited by 120
Cardiopoietic Factors
Noseda, M., Peterkin, T., Simões, F. C., Patient, R. K., & Schneider, M. D. (2011) · Circulation Research · doi:10.1161/circresaha.110.223792 · Cited by 120
Three-dimensional direct measurement of cardiomyocyte volume, nuclearity, and ploidy in thick histological sections
Bensley, J. G., Matteo, R. M. D., Harding, R., & Black, M. J. (2016) · Scientific Reports · doi:10.1038/srep23756 · Cited by 125
Role of the SDF-1-CXCR4 axis in stem cell-based therapies for ischemic cardiomyopathy
Zaruba, M., & Franz, W. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903460286 · Cited by 121
Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise
Schüttler, D., Clauss, S., Weckbach, L. T., & Brunner, S. (2019) · Cells · doi:10.3390/cells8101128 · Cited by 117
Identifying the Evolutionary Building Blocks of the Cardiac Conduction System
Jensen, B. K., Boukens, B. J., Postma, A. V., Gunst, Q. D., van den Hoff, M. J. B., Moorman, A. F. M., Wang, T., & Christoffels, V. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044231 · Cited by 119
Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair
Cheng, K., Malliaras, K. G., Smith, R. R., Shen, D., Sun, B., Blusztajn, A., Xie, Y., Ibrahim, A., Aminzadeh, M. A., Liu, W., et al. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.08.008 · Cited by 118
Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease
Kataoka, M., & Wang, D. (2014) · Cells · doi:10.3390/cells3030883 · Cited by 118
Sustained Delivery of Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Stimulates Endogenous Cardiac Repair in the Chronic Infarcted Pig Heart
Koudstaal, S., Bastings, M. M. C., Feyen, D. A. M., Waring, C. D., van Slochteren, F. J., Dankers, P. Y. W., Torella, D., Sluijter, J. P. G., Nadal‐Ginard, B., Doevendans, P. A., et al. (2014) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9518-4 · Cited by 118
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment
Liu, H., Zhang, C., Ammanamanchi, N., Suresh, S., Lewarchik, C. M., Rao, K., Uys, G. M., Han, L., Abrial, M., Yimlamai, D., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6419 · Cited by 119
Self-citation
Redox Activity Within the Lysosomal Compartment: Implications for Aging and Apoptosis
Kurz, T., Eaton, J. W., & Brunk, U. T. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3005 · Cited by 121
Glycogen Synthase Kinase-3β Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo
Woulfe, K. C., Gao, E., Lal, H., Harris, D., Fan, Q. N., Vagnozzi, R. J., DeCaul, M., Shang, X., Patel, S., Woodgett, J. R., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.211482 · Cited by 117
Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function
Wnorowski, A. N., Sharma, A., Chen, H., Wu, H., Shao, N., Sayed, N., Liu, C., Countryman, S. M., Stodieck, L., Rubins, K., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.10.006 · Cited by 117
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Suda, M., Paul, K. H., Minamino, T., Miller, J. D., Lerman, A., Ellison, G. M., Tchkonia, T., & Kirkland, J. L. (2023) · Cells · doi:10.3390/cells12091296 · Cited by 119
Autophagy in Hypertensive Heart Disease
Wang, Z. V., Rothermel, B. A., & Hill, J. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.025023 · Cited by 118
Characterization of Long-Term Cultured c-kit + Cardiac Stem Cells Derived From Adult Rat Hearts
Miyamoto, S., Kawaguchi, N., Ellison, G. M., Matsuoka, R., Shinoka, T., & Kurosawa, H. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0041 · Cited by 119
Development of 3D PVA scaffolds for cardiac tissue engineering and cell screening applications
Dattola, E., Parrotta, E. I., Scalise, S., Perozziello, G., Limongi, T., Candeloro, P., Coluccio, M. L., Maletta, C., Bruno, L., Angelis, M. T. D., et al. (2019) · RSC Advances · doi:10.1039/c8ra08187e · Cited by 115
Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish
Han, Y., Chen, A., Umansky, K. B., Oonk, K. A., Choi, W.-Y., Dickson, A. L., Ou, J., Cigliola, V., Yifa, O., Cao, J., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.001 · Cited by 119
lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth
Li, H., Trager, L. E., Liu, X., Hastings, M. H., Xiao, C., Guerra, J. R. B., To, S., Li, G., Yeri, A., Rodosthenous, R. S., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.056850 · Cited by 116
Macrophages in myocardial infarction
Kubota, A., & Frangogiannis, N. G. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2022 · Cited by 123
Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
See, K., Tan, W. L. W., Lim, E. H., Tiang, Z., Lee, L. T., Li, P. Y. Q., Luu, T. D. A., Ackers-Johnson, M. A., & Foo, R. (2017) · Nature Communications · doi:10.1038/s41467-017-00319-8 · Cited by 115
Myocardial NF-κB activation is essential for zebrafish heart regeneration
Karra, R., Knecht, A. K., Kikuchi, K., & Poss, K. D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511209112 · Cited by 117
Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations
Leone, M., Magadum, A., & Engel, F. B. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00559.2015 · Cited by 115
High-Sensitivity Troponin T and Mortality After Elective Percutaneous Coronary Intervention
Ndrepepa, G., Colleran, R., Braun, S., Cassese, S., Hieber, J., Fusaro, M., Kufner, S., Ott, I., Byrne, R. A., Hüsser, O., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.08.059 · Cited by 113
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury
Sereti, K., Nguyen, N. B., Kamran, P., Zhao, P., Ranjbarvaziri, S., Park, S., Sabri, S., Engel, J. D., Sung, K., Kulkarni, R. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02891-z · Cited by 116
High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications
Lazar, D. R., Lazăr, F.-L., Homorodean, C., Cainap, C. I., Focşan, M., Cainap, S. S., & Olinic, D.-M. (2022) · Disease Markers · doi:10.1155/2022/9713326 · Cited by 113
Designing of gradient scaffolds and their applications in tissue regeneration
Pattnaik, A., Sanket, A. S., Pradhan, S., Sahoo, R., Das, S., Pany, S., Douglas, T., Dandela, R., Liu, Q., Rajadas, J., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122078 · Cited by 114
Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle
Hesse, M., Raulf, A., Pilz, G.-A., Haberlandt, C., Klein, A. M., Jabs, R., Zaehres, H., Fuegemann, C. J., Zimmermann, K., Trebicka, J., et al. (2012) · Nature Communications · doi:10.1038/ncomms2089 · Cited by 113
Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans
Sharifi‐Sanjani, M., Oyster, N. M., Tichy, E. D., Bedi, K. C., Harel, O., Margulies, K. B., & Mourkioti, F. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005086 · Cited by 113
Chronic Hypoxemia in Late Gestation Decreases Cardiomyocyte Number but Does Not Change Expression of Hypoxia‐Responsive Genes
Botting, K. J., McMillen, I. C., Forbes, H., Nyengaard, J. R., & Morrison, J. L. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000531 · Cited by 111
This old heart: Cardiac aging and autophagy
Linton, P., Gurney, M. A., Sengstock, D. M., Mentzer, R. M., & Gottlieb, R. A. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.12.017 · Cited by 115
Differentiation of Human Embryonic Stem Cells to Cardiomyocytes for In Vitro and In Vivo Applications
Viđarsson, H., Hyllner, J., & Sartipy, P. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9113-x · Cited by 118
Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state
Paradis, A. N., Gay, M. S., & Zhang, L. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.10.019 · Cited by 118
Heart regeneration: 20 years of progress and renewed optimism
Garbern, J. C., & Lee, R. T. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.01.012 · Cited by 115
Cardiac regeneration: current therapies-future concepts.
Doppler, S. A., Deutsch, M.-A., Lange, R., & Krane, M. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2013.08.71 · Cited by 112
Impact of preterm birth on the developing myocardium of the neonate
Bensley, J. G., Moore, L., Matteo, R. M. D., Harding, R., & Black, M. J. (2017) · Pediatric Research · doi:10.1038/pr.2017.324 · Cited by 112
Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanismsPreprint
Zhang, Y., Li, S., Yuan, L., Tian, Y., Weidenfeld, J., Yang, J., Liu, F., Chokas, A. L., & Morrisey, E. E. (2010) · Genes & Development · doi:10.1101/gad.1929210 · Cited by 110
Empowering Adult Stem Cells for Myocardial Regeneration
Mohsin, S., Siddiqi, S., Collins, B. L., & Sussman, M. A. (2011) · Circulation Research · doi:10.1161/circresaha.111.243071 · Cited by 111
A dual epimorphic and compensatory mode of heart regeneration in zebrafish
Sallin, P., Charles, A.-S. D. P., Duruz, V., Pfefferli, C., & Jaźwińska, A. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.12.002 · Cited by 109
VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration
Ramste, M. O., Sultan, I., Paech, J., Hemanthakumar, K. A., Yu, W., He, L., Tang, J., Sun, Y., Hlushchuk, R., Huan, X., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.050635 · Cited by 111
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
Du, J., Zheng, L., Gao, P., Yang, H., Yang, W., Guo, F., Liang, R., Feng, M., Wang, Z., Zhang, Z., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.03.009 · Cited by 112
Doxorubicin‐Induced Cardiomyopathy in Children
Mancilla, T. R., Iskra, B., & Aune, G. J. (2019) · Comprehensive Physiology · doi:10.1002/cphy.c180017 · Cited by 108
Engineered 3D cardiac fibrotic tissue to study fibrotic remodeling
Sadeghi, A. H., Shin, S. R., Deddens, J. C., Fratta, G., Mandla, S., Yazdi, I. K., Prakash, G., Antona, S., Demarchi, D., Buijsrogge, M. P., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601434 · Cited by 108
Physiologically inspired cardiac scaffolds for tailored in vivo function and heart regeneration
Kaiser, N. J., & Coulombe, K. L. K. (2015) · Biomedical Materials · doi:10.1088/1748-6041/10/3/034003 · Cited by 111
Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart
Smith, A. J., Lewis, F., Aquila, I., Waring, C. D., Nocera, A., Agosti, V., Nadal‐Ginard, B., Torella, D., & Ellison, G. M. (2014) · Nature Protocols · doi:10.1038/nprot.2014.113 · Cited by 108
Challenges in Using Stem Cells for Cardiac Repair
Mummery, C. L., Davis, R. P., & Krieger, J. E. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000558 · Cited by 108
Large-scale production of human pluripotent stem cell derived cardiomyocytes
Kempf, H., Andrée, B., & Zweigerdt, R. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.016 · Cited by 109
The transcription factor GATA4 promotes myocardial regeneration in neonatal mice
Mohammadi, M. M., Kattih, B., Grund, A., Froese, N., Korf‐Klingebiel, M., Gigina, A., Schrameck, U., Rudat, C., Liang, Q., Kispert, A., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606602 · Cited by 113
Phenotype flexibility in wild fish: Dolly Varden regulate assimilative capacity to capitalize on annual pulsed subsidies
Armstrong, J. B., & Bond, M. H. (2013) · Journal of Animal Ecology · doi:10.1111/1365-2656.12066 · Cited by 108
Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction
Kanashiro‐Takeuchi, R. M., Τζιόμαλος, Κ., Takeuchi, L. M., Treuer, A. V., Lamirault, G., Dulce, R. A., Hurtado, M., Song, Y. G., Block, N. L., Rick, F. G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914138107 · Cited by 107
Cardiac Regeneration and Stem Cells
Zhang, Y., Mignone, J., & MacLellan, W. R. (2015) · Physiological Reviews · doi:10.1152/physrev.00021.2014 · Cited by 110
Role of endothelial progenitor cells during ischemia-induced vasculogenesis and collateral formation
Tongers, J., Roncalli, J. G., & Losordo, D. W. (2010) · Microvascular Research · doi:10.1016/j.mvr.2010.01.012 · Cited by 106
Immune responses in cardiac repair and regeneration: a comparative point of view
Lai, S.-L., Marín‐Juez, R., & Stainier, D. Y. R. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2995-5 · Cited by 112
Biological Therapies for Cardiac Arrhythmias
Cho, H. C., & Marbán, E. (2010) · Circulation Research · doi:10.1161/circresaha.109.212936 · Cited by 106
Knockdown of Cyclin-dependent Kinase Inhibitors Induces Cardiomyocyte Re-entry in the Cell Cycle
Stefano, V. D., Giacca, M., Capogrossi, M. C., Crescenzi, M., & Martelli, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.184549 · Cited by 106
Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues
Anafi, R. C., Pellegrino, R., Shockley, K. R., Romer, M. A., Tufik, S., & Pack, A. I. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-362 · Cited by 106
Can Exercise Teach Us How to Treat Heart Disease?
Mann, N., & Rosenzweig, A. (2012) · Circulation · doi:10.1161/circulationaha.111.060376 · Cited by 106
Chemical Engineering of Cell Therapy for Heart Diseases
Li, Z., Hu, S., & Cheng, K. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00137 · Cited by 105
Signaling cascades in the failing heart and emerging therapeutic strategies
He, X., Du, T., Long, T., Liao, X., Dong, Y., & Huang, Z. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00972-6 · Cited by 108
Functional Consequences of Human Induced Pluripotent Stem Cell Therapy
Xiong, Q., Ye, L., Zhang, P., Lepley, M. A., Tian, J., Li, J., Zhang, L., Swingen, C., Vaughan, J. T., Kaufman, D. S., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000641 · Cited by 105
The epicardium signals the way towards heart regeneration
Masters, M., & Riley, P. R. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.04.007 · Cited by 111
Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury
Borden, A., Kurian, J. J., Nickoloff, E., Yang, Y., Troupes, C. D., Ibetti, J., Lucchese, A. M., Gao, E., Mohsin, S., Koch, W. J., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314223 · Cited by 107
Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish
Huang, W., Yang, C., Chen, I.-H., Liu, Y.-M. L., Chang, S., & Chuang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066613 · Cited by 108
Running Forward
Rowe, G. C., Safdar, A., & Arany, Z. P. (2014) · Circulation · doi:10.1161/circulationaha.113.001590 · Cited by 107
Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells
Toyama, B. H., Drigo, R. A. E., Lev‐Ram, V., Ramachandra, R., Deerinck, T. J., Lechène, C., Ellisman, M. H., & Hetzer, M. W. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201809123 · Cited by 103
Animal models in the study of exercise-induced cardiac hypertrophy
Wang, Y., Wisløff, U., & Kemi, O. J. (2010) · Physiological Research · doi:10.33549/physiolres.931928 · Cited by 103
3D Cardiac Microtissues Encapsulated with the Co‐Culture of Cardiomyocytes and Cardiac Fibroblasts
Saini, H., Navaei, A., Putten, A. V., & Nikkhah, M. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500331 · Cited by 106
An Overview of Extracellular Matrix-Based Bioinks for 3D Bioprinting
Wang, H., Yu, H., Zhou, X., Zhang, J., Zhou, H., Hao, H., Ding, L., Li, H., Gu, Y., Ma, J., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.905438 · Cited by 108
Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model
Cai, M.-X., Shi, X.-C., Chen, T., Tan, Z.-N., Lin, Q.-Q., Du, S.-J., & Tian, Z.-J. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.055 · Cited by 101
Prognostic value of sensitive troponin T in patients with stable and unstable angina and undetectable conventional troponin
Ndrepepa, G., Braun, S., Mehilli, J., Birkmeier, K. A., Byrne, R. A., Ott, I., Hösl, K., Schulz, S., Fusaro, M., Pache, J., et al. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.09.018 · Cited by 101
Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering
Yanamandala, M., Zhu, W., Garry, D. J., Kamp, T. J., Hare, J. M., Jun, H., Yoon, Y., Bursac, N., Prabhu, S. D., Dorn, G. W., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.06.012 · Cited by 103
Direct in vivo reprogramming with non-viral sequential targeting nanoparticles promotes cardiac regeneration
Wang, Q., Song, Y., Chen, J., Li, Q., Gao, J., Tan, H., Zhu, Y., Wang, Z., Li, M., Yang, H., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121028 · Cited by 101
Basic science behind the cardiovascular benefits of exercise
Wilson, M. G., Ellison, G. M., & Cable, N. T. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-306596rep · Cited by 112
Molecular mechanisms of cardiomyocyte aging
Sheydina, A., Riordon, D. R., & Boheler, K. R. (2011) · Clinical Science · doi:10.1042/cs20110115 · Cited by 102
Multimodal Regulation of Cardiac Myocyte Proliferation
Yuan, X., & Braun, T. W. (2017) · Circulation Research · doi:10.1161/circresaha.117.308428 · Cited by 102
Cardiac endothelial cells express Wilms' tumor-1
Duim, S. N., Kurakula, K., Goumans, M., & Kruithof, B. P. T. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.02.007 · Cited by 100
Enhanced cell survival and paracrine effects of mesenchymal stem cells overexpressing hepatocyte growth factor promote cardioprotection in myocardial infarction
Zhao, L., Liu, X., Zhang, Y., Liang, X., Ding, Y., Xu, Y., Fang, Z., & Zhang, F. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.03.024 · Cited by 100
Regulation of the cardiomyocyte population in the developing heart
Thornburg, K. L. R., Jonker, S. S., O'Tierney, P. F., Chattergoon, N. N., Louey, S., Faber, J., & Giraud, G. D. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2010.11.010 · Cited by 100
Physiological aspects of cardiac tissue engineering
Eschenhagen, T., Eder, A., Vollert, I., & Hansen, A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00007.2012 · Cited by 103
Exercise effects on cardiovascular disease: from basic aspects to clinical evidence
Sanchis‐Gomar, F., Lavie, C. J., Marín-Puyalto, J., Pérez-Quilis, C., Eijsvogels, T. M. H., O’Keefe, J. H., Perez, M. V., & Blair, S. N. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab272 · Cited by 109
Wnt Signaling in Heart Development and Regeneration
Li, D., Sun, J., & Zhong, T. P. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01756-8 · Cited by 100
Markers of fibrosis, inflammation, and remodeling pathways in heart failure
Passino, C., Barison, A., Vergaro, G., Gabutti, A., Borrelli, C., Emdin, M., & Clerico, A. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.09.006 · Cited by 99
Skeletal Myoblasts for Cardiac Repair
Durrani, S., Анатольевич, К. М., Ashraf, M., & Haider, K. H. (2010) · Regenerative Medicine · doi:10.2217/rme.10.65 · Cited by 99
The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult
Nadal‐Ginard, B., Ellison, G. M., & Torella, D. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.04.008 · Cited by 105
Application of Biomarkers for Risk Stratification in Patients with Atrial Fibrillation
Hijazi, Z., Oldgren, J., Siegbahn, A. G., & Wallentin, L. C. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.255182 · Cited by 104
TLR3 Mediates Repair and Regeneration of Damaged Neonatal Heart through Glycolysis Dependent YAP1 Regulated miR-152 Expression
Wang, X., Ha, T., Liu, L., Hu, Y., Kao, R. L., Kalbfleisch, J. H., Williams, D. L., & Li, C. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0036-9 · Cited by 99
A New Era of Cardiac Cell Therapy: Opportunities and Challenges
Huang, K., Hu, S., & Cheng, K. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801011 · Cited by 98

Authors: Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., Jovinge, S., & Frisén, J.
Affiliations: Lyon 1 Université (FR)
Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Corresponding author: Bergmann, Olaf
Bhardwaj, Ratan D.
ORCID: Bergmann, Olaf
Bernard, Samuel
Alkass, Kanar
Buchholz, Bruce A.
Druid, Henrik
Jovinge, Stefan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-04-03
Volume: 324
Issue: 5923
Pages: 98-102
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1164680
PMC: PMC2991140
OpenAlex: W2101986300
Cited by: 3,130
References: 29
Citations by year: 2026: 85 · 2025: 128 · 2024: 150 · 2023: 145 · 2022: 193 · 2021: 204 · 2020: 178 · 2019: 184 · 2018: 185 · 2017: 224 · 2016: 209 · 2015: 222 · 2014: 232 · 2013: 207 · 2012: 211
FWCI: 77.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: National Institute of General Medical Sciences (P41GM103483)
National Center for Research Resources (RR13461, P41RR013461)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: cardiomyocyte renewal, cardiomyocyte turnover, cellular aging, bomb carbon-14, human heart, cardiac regeneration, cardiac pathology
MeSH terms: Adult, Aged, Aging, Carbon Radioisotopes, Cell Count, Cell Nucleus, Cell Separation, DNA, Humans, Middle Aged, Models, Cardiovascular, Polyploidy, Stem Cells, Echocardiography, Doppler, Color, Troponin I, Troponin T, Myocytes, Cardiac, Cell Nucleus Division, Cell Proliferation, Nuclear Weapons, Radiometric Dating

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for Cardiomyocyte Renewal in Humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks