Cited by 3,130Congenital heart defects researchNeurogenesis and neuroplasticity mechanismsMesenchymal stem cell research

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

Evidence for Cardiomyocyte Renewal in Humans

Open access

Bergmann, Olaf, Bhardwaj, Ratan D., Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A., Druid, Henrik, Jovinge, Stefan, Frisén, Jonas·2009·Science

DOI 10.1126/science.1164680PMC PMC2991140

Open this paper in CoChat — free account

Abstract

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1164680

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357
Self-citation
Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction
Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S., Finato, N., Bussani, R., Nadal‐Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442303 · Cited by 1,426
Regenerating the heart
Laflamme, M. A., & Murry, C. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1117 · Cited by 967
Cardiac tumours: diagnosis and management
BUTANY, J. W., Nair, V., Naseemuddin, A., Nair, G. M., Catton, C., & Yau, T. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70093-0 · Cited by 846
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
Hsieh, P. C. H., Segers, V. F. M., Davis, M. E., MacGillivray, C., Gannon, J., Molkentin, J. D., Robbins, J. M., & Lee, R. T. (2007) · Nature Medicine · doi:10.1038/nm1618 · Cited by 778
Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.
Olivetti, G., Melissari, M., Capasso, J. M., & Anversa, P. (1991) · Circulation Research · doi:10.1161/01.res.68.6.1560 · Cited by 774
Retrospective Birth Dating of Cells in Humans
Spalding, K. L., Bhardwaj, R. D., Buchholz, B. A., Druid, H., & Frisén, J. (2005) · Cell · doi:10.1016/j.cell.2005.04.028 · Cited by 649
Self-citation
Survey of Studies Examining Mammalian Cardiomyocyte DNA Synthesis
Soonpaa, M. H., & Field, L. J. (1998) · Circulation Research · doi:10.1161/01.res.83.1.15 · Cited by 558
Stem-cell-based therapy and lessons from the heart
Passier, R. C., Laake, L. W. V., & Mummery, C. L. (2008) · Nature · doi:10.1038/nature07040 · Cited by 528
The Tropospheric 14CO2 Level in Mid-Latitudes of the Northern Hemisphere (1959–2003)
Levin, I., & Kromer, B. (2004) · Radiocarbon · doi:10.1017/s0033822200033130 · Cited by 527

Flagged first, then by citations

Show all 29 references

1 of the 29 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

V. Brodsky, D. S. Sarkisov, A. M. Arefyeva, N. W. Panova, I. G. Gvasava, Virchows Arch.424, 429 (1994).
P. Pfitzer, Curr. Top. Pathol.54, 125 (1971).

Sorted by citations

Items 501–600 of 1,006

Cardiac tissue remodeling in healthy aging: the road to pathology
Tracy, E. P., Rowe, G., & LeBlanc, A. J. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00021.2020 · Cited by 78
Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: A meta-analysis
Donndorf, P., Kundt, G., Kaminski, A., Yerebakan, C., Liebold, A., Steinhoff, G., & Glass, Ä. (2011) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.12.013 · Cited by 76
Muscle : fundamental biology and mechanisms of disease
Hill, J. A., Olson, E. N., Griendling, K. K., Kitsis, R. N., Stull, J. T., & Sweeney, H. L. (2012) · Cited by 76
AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia
Ruozi, G., Bortolotti, F., Falcione, A., Ferro, M. D., Ukovich, L., Macedo, A., Zentilin, L., Filigheddu, N., Cappellari, G. G., Baldini, G., et al. (2015) · Nature Communications · doi:10.1038/ncomms8388 · Cited by 77
Milestones and current achievements in development of multifunctional bioscaffolds for medical application
Litowczenko, J., Woźniak-Budych, M., Staszak, K., Wieszczycka, K., Jurga, S., & Tylkowski, B. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.007 · Cited by 79
Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer
del Campo, C. V., Liaw, N. Y., Gunadasa-Rohling, M., Matthaei, M., Braga, L., Kennedy, T. L., Salinas, G., Voigt, N., Giacca, M., Zimmermann, W., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab054 · Cited by 78
Myocardial injury, troponin release, and cardiomyocyte death in brief ischemia, failure, and ventricular remodeling
Canty, J. M. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00093.2022 · Cited by 67
Role of the immune system in cardiac tissue damage and repair following myocardial infarction
Saparov, A., Ogay, V. B., Nurgozhin, T. S., Chen, W. C. W., Mansurov, N., Issabekova, A., & Zhakupova, J. (2017) · Inflammation Research · doi:10.1007/s00011-017-1060-4 · Cited by 79
Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration
Natarajan, N., Abbas, Y., Bryant, D. M., González‐Rosa, J. M., Sharpe, M., Uygur, A., Cocco-Delgado, L. H., Ho, N., Gerard, N. P., Gerard, C. J., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.030801 · Cited by 76
Localization of transcripts, translation, and degradation for spatiotemporal sarcomere maintenance
Lewis, Y. E., Moskovitz, A., Mutlak, M., Heineke, J., Caspi, L. H., & Kehat, I. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.01.012 · Cited by 77
Post-ischemic Myocardial Inflammatory Response: A Complex and Dynamic Process Susceptible to Immunomodulatory Therapies
Pluijmert, N. J., Atsma, D. E., & Quax, P. H. A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.647785 · Cited by 75
Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity
Choudhury, S., Huang, A. Y., Kim, J., Zhou, Z., Morillo, K. S., Maury, E. A., Tsai, J. W., Miller, M. B., Lodato, M. A., Araten, S., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00261-5 · Cited by 76
Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy
Kuroshima, T., Kawaguchi, S., & Okada, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094710 · Cited by 78
Aging, telomeres and heart failure
Wong, L. S. M., van der Harst, P., de Boer, R. A., Huzen, J., van Gilst, W. H., & van Veldhuisen, D. J. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9173-7 · Cited by 77
Biochemical Markers of Aging for Longitudinal Studies in Humans
Engelfriet, P. M., Jansen, E. H. J. M., Picavet, H. S. J., & Dollé, M. E. T. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs011 · Cited by 75
Cerebral Aneurysms: Formation, Progression, and Developmental Chronology
Etminan, N., Buchholz, B. A., Dreier, R., Brückner, P., Torner, J. C., Steiger, H., Hänggi, D., & Macdonald, R. L. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0294-x · Cited by 77
Self-citation
Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal
Vermillion, K. L., Anderson, K. J., Hampton, M. E., & Andrews, M. T. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00108.2014 · Cited by 77
Detection and Phenotypic Characterization of Adult NeurogenesisPreprint
Kuhn, H. G., Eisch, A. J., Spalding, K. L., & Peterson, D. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a025981 · Cited by 77
Diploid hepatocytes drive physiological liver renewal in adult humans
Heinke, P., Rost, F., Rode, J., Trus, P., Simonova, I., Lázár, E., Feddema, J., Welsch, T., Alkass, K., Salehpour, M., et al. (2022) · Cell Systems · doi:10.1016/j.cels.2022.05.001 · Cited by 73
Self-citation
Novel therapeutic strategies for cardioprotection
Sluijter, J. P. G., Condorelli, G., Davidson, S. M., Engel, F. B., Ferdinandy, P., Hausenloy, D. J., Lecour, S., Madonna, R., Ovize, M., Ruiz‐Meana, M., et al. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.05.005 · Cited by 74
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration
Yi, B. A., Wernet, O., & Chien, K. R. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40820 · Cited by 73
miRNA in cardiac development and regeneration
Ouyang, Z., & Wei, K. (2021) · Cell Regeneration · doi:10.1186/s13619-021-00077-5 · Cited by 77
Divergent Requirements for EZH1 in Heart Development Versus Regeneration
Ai, S., Yu, X., Li, Y., Peng, Y., Li, C., Yue, Y., Tao, G., Li, C., Pu, W. T., & He, A. (2017) · Circulation Research · doi:10.1161/circresaha.117.311212 · Cited by 76
Cardiac Progenitor Cell–Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation
Maring, J. A., Lodder, K., Mol, E. A., Verhage, V., Wiesmeijer, K. C., Dingenouts, C. K. E., Moerkamp, A. T., Deddens, J. C., Vader, P., Smits, A. M., et al. (2018) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-018-9842-9 · Cited by 76
FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry
Rochais, F., Sturny, R., Chao, C., Mesbah, K., Bennett, M., Mohun, T. J., Bellusci, S., & Kelly, R. G. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu232 · Cited by 74
A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
Singh, B. N., Koyano‐Nakagawa, N., Gong, W., Moskowitz, I. P. G., Weaver, C. V., Braunlin, E., Das, S., van Berlo, J. H., Garry, M. G., & Garry, D. J. (2018) · Nature Communications · doi:10.1038/s41467-018-06617-z · Cited by 72
hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration
Sun, J., Peterson, E., Wang, A. Z., Ou, J., Smith, K. E., Poss, K. D., & Wang, J. (2022) · Circulation · doi:10.1161/circulationaha.121.055468 · Cited by 74
Multifaceted roles of miR-1s in repressing the fetal gene program in the heart
Wei, Y., Peng, S., Wu, M., Sachidanandam, R., Tu, Z., Zhang, S., Falce, C., Sobie, E. A., Lebeche, D., & Zhao, Y. B. (2014) · Cell Research · doi:10.1038/cr.2014.12 · Cited by 72
Nuclear cardiac troponin and tropomyosin are expressed early in cardiac differentiation of rat mesenchymal stem cells
Asumda, F. Z., & Chase, P. B. (2011) · Differentiation · doi:10.1016/j.diff.2011.10.002 · Cited by 72
Early markers for myocardial ischemia and sudden cardiac death
Sabatasso, S., Mangin, P. J., Fracasso, T., Moretti, M., Docquier, M., & Djonov, V. (2016) · International Journal of Legal Medicine · doi:10.1007/s00414-016-1401-9 · Cited by 72
Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats
Stenzig, J., Schneeberger, Y., Löser, A., Peters, B. S., Schaefer, A., Zhao, R., Ng, S. L., Höppner, G., Geertz, B., Hirt, M. N., et al. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.05.012 · Cited by 71
Heart-Breaking Telomeres
Martínez, P., & Blasco, M. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312202 · Cited by 74
Regulators of cardiac fibroblast cell state
Bretherton, R. C., Bugg, D., Olszewski, E., & Davis, J. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.04.002 · Cited by 71
Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies
Mazzola, M., & Pasquale, E. D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00455 · Cited by 71
Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle
Liu, X., Pu, W., He, L., Li, Y., Zhao, H., Li, Y., Liu, K., Huang, X., Weng, W., Wang, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25933-5 · Cited by 72
Future treatment strategies in ST-segment elevation myocardial infarction
Windecker, S., Bax, J. J., Myat, A., Stone, G. W., & Marber, M. S. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61452-x · Cited by 72
Regenerative medicine: then and now – an update of recent history into future possibilities
Polykandriotis, E., Popescu, L. M., & Horch, R. E. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01169.x · Cited by 71
Wnt/β-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes
Buikema, J. W., Mady, A. S. A., Mittal, N., Atmanli, A., Caron, L., Doevendans, P. A., Sluijter, J. P. G., & Domian, I. J. (2013) · Development · doi:10.1242/dev.099325 · Cited by 73
Proteostasis and REDOX state in the heart
Christians, E., & Benjamin, I. J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00903.2011 · Cited by 71
Function and form in the developing cardiovascular system
Sedmera, D. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr062 · Cited by 71
Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure
Agarwal, U., Smith, A. W., French, K. M., Boopathy, A. V., George, A. B., Trac, D. Q., Brown, M. E., Shen, M., Jiang, R., Fernandez, J. D., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0241 · Cited by 71
Inhibition of Senescence‐Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post–Myocardial Infarction
Alam, P., Haile, B., Arif, M., Pandey, R., Rokvic, M., Nieman, M. L., Maliken, B. D., Paul, A., Wang, Y., Sadayappan, S., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012089 · Cited by 71
A guide in lentiviral vector production for hard-to-transfect cells, using cardiac-derived c-kit expressing cells as a model system
Kalidasan, V., Ng, W. H., Ishola, O. A., Ravichantar, N., Tan, J. J., & Das, K. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-98657-7 · Cited by 70
Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering
El‐Husseiny, H. M., Mady, E. A., El‐Dakroury, W. A., Doghish, A. S., & Tanaka, R. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1174075 · Cited by 73
Regeneration versus scarring in vertebrate appendages and heart
Jaźwińska, A., & Sallin, P. (2015) · The Journal of Pathology · doi:10.1002/path.4644 · Cited by 74
Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix
Wu, C. C., Jeratsch, S., Graumann, J., & Stainier, D. Y. R. (2020) · Circulation Research · doi:10.1161/circresaha.119.316303 · Cited by 71
The Hypoxic Epicardial and Subepicardial Microenvironment
Kocabaş, F., Mahmoud, A. I., Šošić, D., Porrello, E. R., Chen, R., Garcia, J. A., DeBerardinis, R. J., & Sadek, H. A. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9366-7 · Cited by 69
Contribution of Bone Marrow-Derived Hematopoietic Stem/Progenitor Cells to the Generation of Donor-Marker+ Cardiomyocytes In Vivo
Fukata, M., Ishikawa, F., Najima, Y., Yamauchi, T., Saito, Y., Takenaka, K., Miyawaki, K., Shimazu, H., Shimoda, K., Kanemaru, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062506 · Cited by 69
The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart
Mathiyalagan, P., Okabe, J., Chang, L., Su, Y. R., Du, X., & El‐Osta, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt896 · Cited by 72
Cardiac tissue engineering and regeneration using cell-based therapy
Alrefai, M., Murali, D., Paul, A., Ridwan, K., Connell, J., & Shum‐Tim, D. (2015) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s54204 · Cited by 69
Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening
Sharma, A., Wu, J. C., & Wu, S. M. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt380 · Cited by 72
Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2
Przybyt, E., Krenning, G., Brinker, M. G. L., & Harmsen, M. C. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-39 · Cited by 69
Mechanotransduction via the LINC complex regulates DNA replication in myonuclei
Wang, S., Stoops, E., Unnikannan, C. P., Markus, B., Reuveny, A., Ordan, E., & Volk, T. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201708137 · Cited by 75
Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies
Liu, K., Jin, H., & Zhou, B. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011631 · Cited by 69
Mesenchymal Stem Cells in Cardiology
White, I. A., Sanina, C., Balkan, W., & Hare, J. M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3584-0_4 · Cited by 68
Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies
Windmueller, R., Leach, J. P., Babu, A., Zhou, S., Morley, M. P., Wakabayashi, A., Petrenko, N. B., Viatour, P., & Morrisey, E. E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.034 · Cited by 73
Analytical characteristics of the Roche highly sensitive troponin T assay and its application to a cardio-healthy population
Koerbin, G., Tate, J. R., & Hickman, P. E. (2010) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2010.010033 · Cited by 68
Cardiac Regeneration using Growth Factors: Advances and Challenges
Rebouças, J. D. S., Santos-Magalhães, N. S., & Formiga, F. R. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160097 · Cited by 68
Progress and Challenge of Cardiac Regeneration to Treat Heart Failure
Isomi, M., Sadahiro, T., & Ieda, M. (2018) · Journal of Cardiology · doi:10.1016/j.jjcc.2018.10.002 · Cited by 69
Challenges measuring cardiomyocyte renewal
Soonpaa, M. H., Rubart, M., & Field, L. J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.029 · Cited by 68
Reprogramming toward Heart Regeneration: Stem Cells and Beyond
Aguirre, A., Sancho-Martinez, I., & Belmonte, J. C. I. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.02.008 · Cited by 67
Ionizing radiation and heart risks
Bhattacharya, S., & Asaithamby, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.01.045 · Cited by 67
Cardiomyocyte Proliferation
Yutzey, K. E. (2017) · Circulation Research · doi:10.1161/circresaha.116.310058 · Cited by 71
Pathophysiology and therapeutic potential of cardiac fibrosis
Hara, H., Takeda, N., & Komuro, I. (2017) · Inflammation and Regeneration · doi:10.1186/s41232-017-0046-5 · Cited by 69
Stimulating Cardiogenesis as a Treatment for Heart Failure
Heallen, T. R., Kadow, Z. A., Jong Heon, K. I. M., Wang, J., & Martin, J. F. (2019) · Circulation Research · doi:10.1161/circresaha.118.313573 · Cited by 68
Cell generation dynamics underlying naive T-cell homeostasis in adult humans
Mold, J. E., Réu, P., Olin, A., Bernard, S., Michaëlsson, J., Rane, S., Yates, A. J., Khosravi, A., Salehpour, M., Possnert, G., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000383 · Cited by 70
Self-citation
The Ephrin A1–EphA2 System Promotes Cardiac Stem Cell Migration After Infarction
Goichberg, P., Bai, Y., D’Amario, D., Ferreira‐Martins, J., Fiorini, C., Zheng, H., Signore, S., del Monte, F., Ottolenghi, S., D’Alessandro, D. A., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.239459 · Cited by 66
Retracted
Nano‐Enabled Approaches for Stem Cell‐Based Cardiac Tissue Engineering
Kharaziha, M., Memić, A., Akbari, M., Brafman, D. A., & Nikkhah, M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600088 · Cited by 69
Recent advances in bioprinting technologies for engineering hepatic tissue
Agarwal, T., Banerjee, D., Konwarh, R., Esworthy, T. J., Kumari, J., Onesto, V., Das, P., Lee, B. H., Wagener, F. A. D. T. G., Makvandi, P., et al. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112013 · Cited by 68
GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration
Fajardo, V. M., Feng, I., Chen, B. Y., Perez-Ramirez, C. A., Shi, B., Clark, P. M., Tian, R., Lien, C., Pellegrini, M. A., Christofk, H. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88159-x · Cited by 69
A coalition to heal—the impact of the cardiac microenvironment
Tzahor, E., & Dimmeler, S. (2022) · Science · doi:10.1126/science.abm4443 · Cited by 72
Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
Aćimović, I., Vilotić, A., Pešl, M., Lacampagne, A., Dvořák, P., Rotrekl, V., & Méli, A. C. (2014) · BioMed Research International · doi:10.1155/2014/512831 · Cited by 70
The role of microRNAs in cardiac development and regenerative capacity
Katz, M. G., Fargnoli, A. S., Kendle, A. P., Hajjar, R. J., & Bridges, C. R. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00181.2015 · Cited by 69
Plasma cardiac troponin I concentrations in healthy neonates, children and adolescents measured with a high sensitive immunoassay method
Caselli, C., Cangemi, G., Masotti, S., Ragusa, R., Gennai, I., Ry, S. D., Prontera, C., & Clerico, A. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.04.029 · Cited by 67
Etiology and Morphogenesis of Congenital Heart Disease
Yamagishi, H., Srivastava, D., Keller, B. B., Hs, B., Markwald, R. R., & Nakanishi, T. (2016) · Springer eBooks · doi:10.1007/978-4-431-54628-3 · Cited by 68
IGF1 and NRG1 Enhance Proliferation, Metabolic Maturity, and the Force-Frequency Response in hESC-Derived Engineered Cardiac Tissues
Rupert, C. E., & Coulombe, K. L. K. (2017) · Stem Cells International · doi:10.1155/2017/7648409 · Cited by 66
Cardiomyocyte Renewal
Parmacek, M. S., & Epstein, J. A. (2009) · New England Journal of Medicine · doi:10.1056/nejmcibr0903347 · Cited by 66
A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation
Bahrami-Nejad, Z., Zhao, M. L., Tholen, S., Hunerdosse, D., Tkach, K. E., van Schie, S., Chung, M., & Teruel, M. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.012 · Cited by 65
Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue
Ardehali, R., Ali, S. R., Inlay, M. A., Abilez, O. J., Chen, M. Q., Blauwkamp, T. A., Yazawa, M., Gong, Y., Nusse, R., Drukker, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220832110 · Cited by 65
Role of c-Kit in Myocardial Regeneration and Aging
Marino, F., Scalise, M., Cianflone, E., Mancuso, T., Aquila, I., Agosti, V., Torella, M., Paolino, D., Mollace, V., Nadal‐Ginard, B., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00371 · Cited by 67
Hooked on heart regeneration: the zebrafish guide to recovery
Stewart, K. R., Walker, S. L. M., Baker, A. H., Riley, P. R., & Brittan, M. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab214 · Cited by 66
Cardiac Regeneration
Choi, W.-Y., & Poss, K. D. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00010-5 · Cited by 67
Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B
Vujić, A., Robinson, E. L., Ito, M., Haider, S. A., Ackers-Johnson, M. A., See, K., Methner, C., Figg, N., Brien, P., Roderick, H. L., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.03.007 · Cited by 65
Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal
Kreipke, R. E., & Birren, S. J. (2015) · The Journal of Physiology · doi:10.1113/jp270917 · Cited by 65
Stem Cell Factor Gene Transfer Promotes Cardiac Repair After Myocardial Infarction via In Situ Recruitment and Expansion of c-kit + Cells
Yaniz‐Galende, E., Chen, J., Chemaly, E. R., Liang, L., Hulot, J., McCollum, L. T., Arias, T., Fuster, V., Zsebo, K. M., & Hajjar, R. J. (2012) · Circulation Research · doi:10.1161/circresaha.111.263830 · Cited by 65
How Plastic Are Pericytes?
Birbrair, A., Borges, I. D. T., Sena, I. F. G., Almeida, G. G., Meirelles, L. D. S., Gonçalves, R., Mintz, A., & Delbono, O. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0044 · Cited by 68
Cardiomyocyte death in sepsis: Mechanisms and regulation (Review)
Zhang, G., Dan, D., Wan, X., & Zhang, Y. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12773 · Cited by 64
Long-Term Myocardial Scarring After Operation for Anomalous Left Coronary Artery From the Pulmonary Artery
Fratz, S., Hager, A., Schreiber, C., Schwaiger, M., Hess, J., & Stern, H. C. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.06.021 · Cited by 64
Aspectos fisiopatológicos do envelhecimento humano e quedas em idosos
Esquenazi, D., Silva, S. B. D., & Guimarães, M. A. (2014) · Revista Hospital Universitário Pedro Ernesto · doi:10.12957/rhupe.2014.10124 · Cited by 76
Stimulating Myocardial Regeneration with Periostin Peptide in Large Mammals Improves Function Post-Myocardial Infarction but Increases Myocardial Fibrosis
Ladage, D., Yaniz‐Galende, E., Rapti, K., Ishikawa, K., Tilemann, L. M., Shapiro, S., Takewa, Y., Müller‐Ehmsen, J., Schwarz, M., Garcia, M. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059656 · Cited by 64
Diurnal physiology: core principles with application to the pathogenesis, diagnosis, prevention, and treatment of myocardial hypertrophy and failure
Sole, M. J., & Martino, T. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00426.2009 · Cited by 66
Wnt Signaling and Aging-Related Heart Disorders
Naito, A. T., Shiojima, I., & Komuro, I. (2010) · Circulation Research · doi:10.1161/circresaha.110.223776 · Cited by 64
Engineering cell platforms for myocardial regeneration
Sarig, U., & Machluf, M. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.578574 · Cited by 65
Heart regeneration in adult Xenopus tropicalis after apical resection
Liao, S., Dong, W., Lv, L., Guo, H., Yang, J., Zhao, H., Huang, R., Yuan, Z., Chen, Y., Feng, S., et al. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0199-6 · Cited by 64
Beyond pharmacological treatment: an insight into therapies that target specific aspects of heart failure pathophysiology
Normand, C., Kaye, D. M., Povsic, T. J., & Dickstein, K. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32216-5 · Cited by 67
Zebrafish as a Smart Model to Understand Regeneration After Heart Injury: How Fish Could Help Humans
Beffagna, G. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00107 · Cited by 72
The interaction of Notch and Wnt signaling pathways in vertebrate regeneration
Gao, J., Fan, L., Zhao, L., & Su, Y. (2021) · Cell Regeneration · doi:10.1186/s13619-020-00072-2 · Cited by 66
RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development
Gan, P., Wang, Z., Morales, M. G., Zhang, Y., Bassel‐Duby, R., Liu, N., & Olson, E. N. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.03.017 · Cited by 63
Monophasic and Biphasic Electrical Stimulation Induces a Precardiac Differentiation in Progenitor Cells Isolated from Human Heart
Pietronave, S., Zamperone, A., Oltolina, F., Colangelo, D., Follenzi, A., Novelli, E., Diena, M., Pavesi, A., Consolo, F., Fiore, G. B., et al. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0375 · Cited by 63
Anti-Ro/SSA Antibodies and Cardiac Arrhythmias in the Adult: Facts and Hypotheses
Lazzerini, P. E., Capecchi, P. L., & Pasini, F. L. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02428.x · Cited by 63

Authors: Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., Jovinge, S., & Frisén, J.
Affiliations: Lyon 1 Université (FR)
Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Corresponding author: Bergmann, Olaf
Bhardwaj, Ratan D.
ORCID: Bergmann, Olaf
Bernard, Samuel
Alkass, Kanar
Buchholz, Bruce A.
Druid, Henrik
Jovinge, Stefan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-04-03
Volume: 324
Issue: 5923
Pages: 98-102
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1164680
PMC: PMC2991140
OpenAlex: W2101986300
Cited by: 3,130
References: 29
Citations by year: 2026: 85 · 2025: 128 · 2024: 150 · 2023: 145 · 2022: 193 · 2021: 204 · 2020: 178 · 2019: 184 · 2018: 185 · 2017: 224 · 2016: 209 · 2015: 222 · 2014: 232 · 2013: 207 · 2012: 211
FWCI: 77.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: National Institute of General Medical Sciences (P41GM103483)
National Center for Research Resources (RR13461, P41RR013461)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: cardiomyocyte renewal, cardiomyocyte turnover, cellular aging, bomb carbon-14, human heart, cardiac regeneration, cardiac pathology
MeSH terms: Adult, Aged, Aging, Carbon Radioisotopes, Cell Count, Cell Nucleus, Cell Separation, DNA, Humans, Middle Aged, Models, Cardiovascular, Polyploidy, Stem Cells, Echocardiography, Doppler, Color, Troponin I, Troponin T, Myocytes, Cardiac, Cell Nucleus Division, Cell Proliferation, Nuclear Weapons, Radiometric Dating

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for Cardiomyocyte Renewal in Humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks