Cited by 3,130Congenital heart defects researchNeurogenesis and neuroplasticity mechanismsMesenchymal stem cell research

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

Evidence for Cardiomyocyte Renewal in Humans

Open access

Bergmann, Olaf, Bhardwaj, Ratan D., Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A., Druid, Henrik, Jovinge, Stefan, Frisén, Jonas·2009·Science

DOI 10.1126/science.1164680PMC PMC2991140

Open this paper in CoChat — free account

Abstract

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1164680

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357
Self-citation
Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction
Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S., Finato, N., Bussani, R., Nadal‐Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442303 · Cited by 1,426
Regenerating the heart
Laflamme, M. A., & Murry, C. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1117 · Cited by 967
Cardiac tumours: diagnosis and management
BUTANY, J. W., Nair, V., Naseemuddin, A., Nair, G. M., Catton, C., & Yau, T. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70093-0 · Cited by 846
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
Hsieh, P. C. H., Segers, V. F. M., Davis, M. E., MacGillivray, C., Gannon, J., Molkentin, J. D., Robbins, J. M., & Lee, R. T. (2007) · Nature Medicine · doi:10.1038/nm1618 · Cited by 778
Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.
Olivetti, G., Melissari, M., Capasso, J. M., & Anversa, P. (1991) · Circulation Research · doi:10.1161/01.res.68.6.1560 · Cited by 774
Retrospective Birth Dating of Cells in Humans
Spalding, K. L., Bhardwaj, R. D., Buchholz, B. A., Druid, H., & Frisén, J. (2005) · Cell · doi:10.1016/j.cell.2005.04.028 · Cited by 649
Self-citation
Survey of Studies Examining Mammalian Cardiomyocyte DNA Synthesis
Soonpaa, M. H., & Field, L. J. (1998) · Circulation Research · doi:10.1161/01.res.83.1.15 · Cited by 558
Stem-cell-based therapy and lessons from the heart
Passier, R. C., Laake, L. W. V., & Mummery, C. L. (2008) · Nature · doi:10.1038/nature07040 · Cited by 528
The Tropospheric 14CO2 Level in Mid-Latitudes of the Northern Hemisphere (1959–2003)
Levin, I., & Kromer, B. (2004) · Radiocarbon · doi:10.1017/s0033822200033130 · Cited by 527

Show all 29 references

Research works printed but not linked: 2

V. Brodsky, D. S. Sarkisov, A. M. Arefyeva, N. W. Panova, I. G. Gvasava, Virchows Arch.424, 429 (1994).
P. Pfitzer, Curr. Top. Pathol.54, 125 (1971).

Sorted by citations

Items 401–500 of 1,006

Exercise for the heart: signaling pathways
Tao, L., Bei, Y., Zhang, H., Xiao, J., & Li, X. (2015) · Oncotarget · doi:10.18632/oncotarget.4770 · Cited by 99
Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment
Spetz, J. K. E., Moslehi, J. J., & Sarosiek, K. A. (2018) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-018-0627-x · Cited by 100
Genetic Lineage Tracing of Sca-1 + Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart
Vagnozzi, R. J., Sargent, M. A., Lin, S. J., Palpant, N. J., Murry, C. E., & Molkentin, J. D. (2018) · Circulation · doi:10.1161/circulationaha.118.035210 · Cited by 97
Molecular Atlas of Postnatal Mouse Heart Development
Talman, V., Teppo, J., Pöhö, P., Movahedi, P., Vaikkinen, A., Karhu, S. T., Trôst, K., Suvitaival, T., Heikkonen, J., Pahikkala, T., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.010378 · Cited by 99
Towards chamber specific heart-on-a-chip for drug testing applications
Zhao, Y., Rafatian, N., Wang, E. Y., Wu, Q., Lai, B., Lu, R. X. Z., Savoji, H., & Radisic, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.002 · Cited by 100
Non-coding RNA therapeutics for cardiac regeneration
Braga, L., Ali, H., Secco, I., & Giacca, M. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa071 · Cited by 98
Longevity of human islet α ‐ and β ‐cells
Cnop, M., Igoillo‐Esteve, M., Hughes, S. J., Walker, J. N., Cnop, I., & Clark, A. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01443.x · Cited by 100
microRNAs in cardiac development and regeneration
Porrello, E. R. (2013) · Clinical Science · doi:10.1042/cs20130011 · Cited by 100
Myocyte proliferation in the developing heart
Sedmera, D., & Thompson, R. P. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22650 · Cited by 98
Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration
Wallner, M., Duran, J. M., Mohsin, S., Troupes, C. D., Vanhoutte, D., Borghetti, G., Vagnozzi, R. J., Gross, P., Yu, D., Trappanese, D. M., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308687 · Cited by 95
Cardiotoxic effects of angiogenesis inhibitors
Dobbin, S. J. H., Petrie, M. C., Myles, R. C., Touyz, R. M., & Lang, N. N. (2021) · Clinical Science · doi:10.1042/cs20200305 · Cited by 98
Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration
Han, L., Choudhury, S., Mich-Basso, J. D., Ammanamanchi, N., Ganapathy, B., Suresh, S., Khaladkar, M., Singh, J. M., Maehr, R., Zuppo, D. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.030 · Cited by 94
Reverse Remodeling With Left Ventricular Assist Devices
Burkhoff, D., Topkara, V. K., Sayer, G., & Uriel, N. (2021) · Circulation Research · doi:10.1161/circresaha.121.318160 · Cited by 98
Cell maturation: Hallmarks, triggers, and manipulation
Alvarez‐Dominguez, J. R., & Melton, D. A. (2022) · Cell · doi:10.1016/j.cell.2021.12.012 · Cited by 96
C3orf58 , a Novel Paracrine Protein, Stimulates Cardiomyocyte Cell-Cycle Progression Through the PI3K–AKT–CDK7 Pathway
Beigi, F., Schmeckpeper, J., Pow-anpongkul, P., Payne, J. A., Zhang, L., Zhang, Z., Huang, J., Mirotsou, M., & Dzau, V. J. (2013) · Circulation Research · doi:10.1161/circresaha.113.301075 · Cited by 95
Predictors of cardiac troponin release after a marathon
Eijsvogels, T. M. H., Hoogerwerf, M. D., Maessen, M. F. H., Seeger, J. P. H., George, K., Hopman, M. T. E., & Thijssen, D. H. J. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2013.12.002 · Cited by 99
Bioenergetic and Functional Consequences of Cellular Therapy
Xiong, Q., Ye, L., Zhang, P., Lepley, M. A., Swingen, C., Zhang, L., Kaufman, D. S., & Zhang, J. J. (2012) · Circulation Research · doi:10.1161/circresaha.112.269894 · Cited by 95
Organs-on-a-chip: a union of tissue engineering and microfabrication
Zhao, Y., Wang, E. Y., Lai, F. B. L., Cheung, K., & Radisic, M. (2023) · Trends in Biotechnology · doi:10.1016/j.tibtech.2022.12.018 · Cited by 93
Advances in Injectable Hydrogel Strategies for Heart Failure Treatment
He, S., Zhang, Z., Luo, R., Jiang, Q., Li, Y., & Wang, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300029 · Cited by 97
Protein Quality Control and Metabolism: Bidirectional Control in the Heart
Wang, Z. V., & Hill, J. A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.016 · Cited by 95
Peripheral blood mononuclear cell secretome for tissue repair
Beer, L., Mildner, M., Gyöngyösi, M., & Ankersmit, H. J. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1292-8 · Cited by 97
The Hippo signal transduction network in skeletal and cardiac muscle
Wackerhage, H., Del Re, D. P., Judson, R. N., Sudol, M., & Sadoshima, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005096 · Cited by 92
Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
Cui, M., Wang, Z., Bassel-Duby, R., & Olson, E. N. (2018) · Development · doi:10.1242/dev.171983 · Cited by 92
Localization of Islet-1–Positive Cells in the Healthy and Infarcted Adult Murine Heart
Weinberger, F., Mehrkens, D., Friedrich, F. W., Stubbendorff, M., Hua, X., Müller, J. C., Schrepfer, S., Evans, S. Μ., Carrier, L., & Thomas Eschenhagen, A. (2012) · Circulation Research · doi:10.1161/circresaha.111.259630 · Cited by 92
Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment
Botting, K. J., Wang, K., Padhee, M., McMillen, I. C., Summers-Pearce, B., Rattanatray, L., Cutri, N., Posterino, G. S., Brooks, D. A., & Morrison, J. L. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05649.x · Cited by 94
Wnt Signaling Exerts an Antiproliferative Effect on Adult Cardiac Progenitor Cells Through IGFBP3
Oikonomopoulos, A., Sereti, K., Conyers, F., Bauer, M. W., Liao, A., Guan, J., Crapps, D., Han, J., Dong, H., Bayomy, A. F., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.250282 · Cited by 92
Telomere shortening is a hallmark of genetic cardiomyopathies
Chang, A. C. Y., Chang, A. C. H., Kirillova, A., Sasagawa, K., Su, W., Weber, G., Lin, J., Termglinchan, V., Karakikes, I., Seeger, T., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714538115 · Cited by 91
The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications
Clerico, A., Zaninotto, M., Ripoli, A., Masotti, S., Prontera, C., Passino, C., & Plebani, M. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0933 · Cited by 91
The Stuttering Progress of Cell Therapy for Heart Disease
Malliaras, K. G., Kreke, M. R., & Marbán, E. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.175 · Cited by 90
Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction
Malliaras, K. G., Ibrahim, A., Tseliou, E., Liu, W., Sun, B., Middleton, R., Seinfeld, J., Wang, L., Sharifi, B. G., & Marbán, E. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303626 · Cited by 90
Long Non-coding RNA ECRAR Triggers Post-natal Myocardial Regeneration by Activating ERK1/2 Signaling
Chen, Y., Li, X., Li, B., Wang, H., Li, M., Huang, S., Sun, Y., Chen, G., Si, X., Huang, C., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.10.021 · Cited by 90
Biomimetic Materials and Scaffolds for Myocardial Tissue Regeneration
Silvestri, A., Boffito, M., Sartori, S., & Ciardelli, G. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201200483 · Cited by 93
Concise Review: Cell Therapy and Tissue Engineering for Cardiovascular Disease
Haraguchi, Y., Shimizu, T., Yamato, M., & Okano, T. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0030 · Cited by 90
Cardiac repair and regeneration: the Rubik’s cube of cell therapy for heart disease
Boudoulas, K. D., & Hatzopoulos, A. K. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.000240 · Cited by 91
ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection
Niwa, O., Barcellos‐Hoff, M. H., Globus, R. K., Harrison, J. D., Hendry, J. H., Jacob, P., Martin, M. T., Seed, T. M., Shay, J. W., Story, M. D., et al. (2015) · Annals of the ICRP · doi:10.1177/0146645315595585 · Cited by 91
Metallothionein and the biology of aging
Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.007 · Cited by 89
Telocytes and putative stem cells in ageing human heart
Popescu, L. M., Curici, A., Wang, E., Zhang, H., Hu, S., & Gherghiceanu, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12509 · Cited by 89
Pluripotent Stem Cell-Derived Cardiomyocytes as a Platform for Cell Therapy Applications: Progress and Hurdles for Clinical Translation
Oikonomopoulos, A., Kitani, T., & Wu, J. C. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.02.026 · Cited by 89
Myocardial apoptosis in heart disease: does the emperor have clothes?
Corbalan, J. J., Vatner, D. E., & Vatner, S. F. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0549-2 · Cited by 93
Modeling Cardiac Disease Mechanisms Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Progress, Promises and Challenges
Parrotta, E. I., Lucchino, V., Scaramuzzino, L., Scalise, S., & Cuda, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124354 · Cited by 88
Immune cells in repair of the infarcted myocardium
Chen, B., & Frangogiannis, N. G. (2016) · Microcirculation · doi:10.1111/micc.12305 · Cited by 93
Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair
Magadum, A., Ding, Y., He, L., Kim, T., Vasudevarao, M. D., Long, Q., Yang, K., Wickramasinghe, N. M., Renikunta, H. V., Dubois, N. C., et al. (2017) · Cell Research · doi:10.1038/cr.2017.84 · Cited by 89
Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice
Roh, J. D., Houstis, N. E., Yu, A., Chang, B. J., Yeri, A., Li, H., Hobson, R., Lerchenmüller, C., Vujić, A., Chaudhari, V., et al. (2020) · Aging Cell · doi:10.1111/acel.13159 · Cited by 95
Cardiomyocyte Polyploidy and Implications for Heart Regeneration
Gan, P., Patterson, M., & Sucov, H. M. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034618 · Cited by 90
Recent Progress in Stem Cell Modification for Cardiac Regeneration
Lemcke, H., Voronina, N., Steinhoff, G., & David, R. (2018) · Stem Cells International · doi:10.1155/2018/1909346 · Cited by 88
Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome
Balbi, C., Lodder, K., Costa, A., Moimas, S., Moccia, F. D., van Herwaarden, T., Rosti, V., Campagnoli, F., Palmeri, A., Biasio, P. D., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.04.011 · Cited by 86
Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of Checkpoint Kinase 1 via Activating Mammalian Target of Rapamycin C1/Ribosomal Protein S6 Kinase b-1 Pathway
Fan, Y., Cheng, Y., Li, Y., Chen, B., Wang, Z., Wei, T., Zhang, H., Guo, Y., Wang, Q., Wei, Y., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.040747 · Cited by 86
Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Herum, K. M., Lunde, I. G., Skrbic, B., Louch, W. E., Hasic, A., Boye, S., Unger, A., Brorson, S.-H., Sjaastad, I., Tønnessen, T., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv002 · Cited by 86
Greater organ involution in highly proliferative tissues associated with the early onset and acceleration of ageing in humans
Richardson, R. B., Allan, D., & Le, Y. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.015 · Cited by 91
Sca-1+ Cardiosphere-Derived Cells Are Enriched for Isl1-Expressing Cardiac Precursors and Improve Cardiac Function after Myocardial Injury
Ye, J., Boyle, A., Shih, H., Sievers, R. E., Zhang, Y., Prasad, M., Su, H., Zhou, Y., Grossman, W., Bernstein, H. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030329 · Cited by 85
Mechanisms of exercise‐induced improvements in the contractile apparatus of the mammalian myocardium
Kemi, O. J., & Wisløff, U. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02132.x · Cited by 85
Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?
Giannoni, A., Giovannini, S., & Clerico, A. (2009) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2009.320 · Cited by 86
Hemodynamic Support by Left Ventricular Assist Devices Reduces Cardiomyocyte DNA Content in the Failing Human Heart
Wohlschlaeger, J., Levkau, B., Brockhoff, G., Schmitz, K. J., von Winterfeld, M., Takeda, A., Takeda, N., Stypmann, J., Vahlhaus, C., Schmid, Ç., et al. (2010) · Circulation · doi:10.1161/circulationaha.108.808071 · Cited by 85
Intramyocardial Injections of Human Mesenchymal Stem Cells following Acute Myocardial Infarction Modulate Scar Formation and Improve Left Ventricular Function
Beitnes, J. O., Øie, E., Shahdadfar, A., Karlsen, T. A., Müller, R. M. B., Aakhus, S., Reinholt, F. P., & Brinchmann, J. E. (2012) · Cell Transplantation · doi:10.3727/096368911x627462 · Cited by 85
Over time, high-sensitivity TnT replaces NT-proBNP as the most powerful predictor of death in patients with dialysis-dependent chronic renal failure
McGill, D. A., Talaulikar, G. S., Potter, J. M., Koerbin, G., & Hickman, P. E. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.03.004 · Cited by 85
C-kit+ cardiac progenitors exhibit mesenchymal markers and preferential cardiovascular commitment
Gambini, E., Pompilio, G., Biondi, A., Alamanni, F., Capogrossi, M. C., Agrifoglio, M., & Pesce, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq292 · Cited by 86
Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation
Aix, E., Gutiérrez‐Gutiérrez, Ó., Sánchez-Ferrer, C., Aguado, T., & Flores, I. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201510091 · Cited by 87
Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells
Xie, Y., Ibrahim, A., Cheng, K., Wu, Z., Liang, W., Malliaras, K. G., Sun, B., Liu, W., Shen, D., Cho, H. C., et al. (2014) · Stem Cells · doi:10.1002/stem.1736 · Cited by 86
Programming and reprogramming a human heart cell
Sahara, M., Santoro, F., & Chien, K. R. (2015) · The EMBO Journal · doi:10.15252/embj.201490563 · Cited by 88
Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?
Silva‐Palacios, A., Königsberg, M., & Zazueta, C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.005 · Cited by 84
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
Marchianò, S., Nakamura, K., Reinecke, H., Neidig, L. E., Lai, M. S., Kadota, S., Perbellini, F., Yang, X., Klaiman, J. M., Blakely, L. P., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.03.010 · Cited by 84
Timing of cardiomyocyte growth, maturation, and attrition in perinatal sheep
Jonker, S. S., Louey, S., Giraud, G. D., Thornburg, K. L. R., & Faber, J. J. (2015) · The FASEB Journal · doi:10.1096/fj.15-272013 · Cited by 84
Stem cell-based therapy in cardiac repair after myocardial infarction: Promise, challenges, and future directions
Yan, W., Xia, Y., Zhao, H., Xu, X., Ma, X., & Tao, L. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.12.009 · Cited by 83
Surviving Acute Organ Failure: Cell Polyploidization and Progenitor Proliferation
Lazzeri, E., Angelotti, M. L., Conte, C., Anders, H., & Romagnani, P. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.006 · Cited by 84
Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms
Zhao, L., Gao, F., Gao, S., Liang, Y., Long, H., Lv, Z., Su, Y., Ye, N., Zhang, L., Zhao, C., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-020-1915-y · Cited by 83
Healthy aging and myocardium: A complicated process with various effects in cardiac structure and physiology
Nakou, E. S., Parthenakis, F. I., Kallergis, E. M., Marketou, M. E., Nakos, K. S., & Vardas, P. E. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.02.039 · Cited by 88
Iron regulator hepcidin impairs macrophage-dependent cardiac repair after injury
Zlatanova, I., Pinto, C., Bonnin, P., Mathieu, J. R. R., Bakker, W., Vilar, J., Lemitre, M., Voehringer, D., Vaulont, S., Peyssonnaux, C., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.034545 · Cited by 81
Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
Chang, A. C. Y., Ong, S.-G., LaGory, E. L., Kraft, P. E., Giaccia, A. J., Wu, J. C., & Blau, H. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615340113 · Cited by 81
LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration
Wu, Y., Zhou, L., Liu, H., Duan, R., Zhou, H., Zhang, F., He, X., Lu, D., Xiong, K., Xiong, M., et al. (2020) · Cell Research · doi:10.1038/s41422-020-00411-7 · Cited by 84
Towards precision medicine in heart failure
Weldy, C. S., & Ashley, E. A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00566-9 · Cited by 81
Artificial Scaffolds in Cardiac Tissue Engineering
Roacho-Pérez, J. A., Garza-Treviño, E. N., Moncada-Saucedo, N. K., Carriquiry-Chequer, P. A., Valencia-Gómez, L. E., Matthews, E. R., Flores, V. G., Simental-Mendía, M. A., González, P. D., Delgado-Gallegos, J. L., et al. (2022) · Life · doi:10.3390/life12081117 · Cited by 85
Understanding cardiomyocyte proliferation: an insight into cell cycle activity
Ponnusamy, M., Li, P., & Wang, K. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2375-y · Cited by 82
Islet-1 Cells Are Cardiac Progenitors Present During the Entire Lifespan: From the Embryonic Stage to Adulthood
Genead, R., Danielsson, C., Andersson, A., Corbascio, M., Franco‐Cereceda, A., Sylvén, C., & Grinnemo, K. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0483 · Cited by 80
Developmental and Regenerative Biology of Multipotent Cardiovascular Progenitor Cells
Sturzu, A. C., & Wu, S. M. (2011) · Circulation Research · doi:10.1161/circresaha.110.227066 · Cited by 82
Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts
Hortells, L., Johansen, A. K. Z., & Yutzey, K. E. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6030029 · Cited by 79
The Elusive Progenitor Cell in Cardiac Regeneration
Cai, C., & Molkentin, J. D. (2017) · Circulation Research · doi:10.1161/circresaha.116.309710 · Cited by 81
PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration
Zhang, Y., Chen, J., Lian, H., Pei, J., Li, Y., Chen, X., Song, S., Xia, J., Zhou, B., Feng, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.065 · Cited by 80
Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration
Abbas, N., Perbellini, F., & Thum, T. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-0816-0 · Cited by 80
Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review)
Chaulin, A. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010928 · Cited by 63
Telomerase Is Essential for Zebrafish Heart Regeneration
Bednarek, D., González‐Rosa, J. M., Guzmán, G., Gutiérrez‐Gutiérrez, Ó., Aguado, T., Sánchez-Ferrer, C., Marques, I. J., Galardi‐Castilla, M., de Diego, I., Gómez, M. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.064 · Cited by 84
Viral Myocarditis: Potential Defense Mechanisms Within The Cardiomyocyte Against Virus Infection
Yajima, T. (2011) · Future Microbiology · doi:10.2217/fmb.11.40 · Cited by 79
Cardiac stem cell niches
Leri, A., Rota, M., Hosoda, T., Goichberg, P., & Anversa, P. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.09.001 · Cited by 78
Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration
Li, X., He, X. F., Wang, H., Li, M., Huang, S., Chen, G., Jing, Y., Wang, S., Chen, Y., Liao, W., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy075 · Cited by 78
Tbx20 promotes cardiomyocyte proliferation and persistence of fetal characteristics in adult mouse hearts
Chakraborty, S., Sengupta, A., & Yutzey, K. E. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.05.018 · Cited by 81
The Vascular Stem Cell Niche
Gómez‐Gaviro, M. V., Lovell-Badge, R. H., Fernández‐Avilés, F., & Lara‐Pezzi, E. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9371-x · Cited by 82
The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction
Marsano, A., Maidhof, R., Luo, J., Fujikara, K., Konofagou, E. E., Banfi, A., & Vunjak‐Novakovic, G. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.038 · Cited by 79
Early- versus Late-Onset Systemic Sclerosis
Alba, M. A., Velasco, C., Simeón‐Aznar, C. P., Fonollosa‐Pla, V., Trapiella, L., Egurbide, M. V., Sáez, L., Castillo, M. J., Callejas-Rubio, J. L., Camps, M. T., et al. (2014) · Medicine · doi:10.1097/md.0000000000000018 · Cited by 78
Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes
Fan, Y., Ho, B. X., Pang, J. K. S., Pek, N. M. Q., Hor, J. H., Ng, S., & Soh, B.-S. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1086-8 · Cited by 79
Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response
Binder, P., Wang, S., Radu, M., Zin, M., Collins, L., Khan, S., Li, Y., Sekeres, K., Humphreys, N. E., Swanton, E., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.312829 · Cited by 77
The Paradoxical Role of Inflammation in Cardiac Repair and Regeneration
Jiang, B., & Liao, R. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9193-7 · Cited by 79
Intrinsic cardiac origin of human cardiosphere-derived cells
White, A. J., Smith, R. R., Matsushita, S., Chakravarty, T., Czer, L. S. C., Burton, K., Schwarz, E. R., Davis, D. R., Wang, Q., Reinsmoen, N. L., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr172 · Cited by 80
Comparison of Cardiac Troponin I and T, Including the Evaluation of an Ultrasensitive Assay, as Indicators of Doxorubicin-induced Cardiotoxicity
Reagan, W. J., York, M. J., Berridge, B. R., Schultze, E., Walker, D. B., & Pettit, S. D. (2013) · Toxicologic Pathology · doi:10.1177/0192623313482056 · Cited by 77
Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
Xiao, C., Gao, L., Hou, Y., Xu, C., Chang, N., Wang, F., Hu, K., He, A., Luo, Y., Wang, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13787 · Cited by 78
Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications
Choi, J. R., Yong, K. W., & Zaman, W. S. W. K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2484-2 · Cited by 78
Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine
Burridge, P. W., Sharma, A., & Wu, J. C. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-112414-054911 · Cited by 78
Cell therapy for human ischemic heart diseases: Critical review and summary of the clinical experiences
Pávó, N., Charwat, S., Nyolczas, N., András, J., Murlasits, Z., Bergler-Klein, J. K., Nikfardjam, M., Benedek, I., Benedek, T., Pavo, I. J., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.06.016 · Cited by 77
Concise Review: Heart Regeneration and the Role of Cardiac Stem Cells
Koudstaal, S., Lorkeers, S. J. J. O., Gaetani, R., Gho, J. M. I. H., van Slochteren, F. J., Sluijter, J. P. G., Doevendans, P. A., Ellison, G. M., & Chamuleau, S. A. J. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0001 · Cited by 80
Hypoxic Preconditioning Improves Survival of Cardiac Progenitor Cells: Role of Stromal Cell Derived Factor-1α–CXCR4 Axis
Yan, F., Yao, Y., Chen, L., Li, Y., Sheng, Z., & Ma, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037948 · Cited by 76
Human cardiomyocyte generation from pluripotent stem cells: A state-of-art
Talkhabi, M., Aghdami, N., & Baharvand, H. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.12.023 · Cited by 76
Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction
Johnston, J. R., Chase, P. B., & Pinto, J. R. (2017) · Oncotarget · doi:10.18632/oncotarget.22879 · Cited by 76

Authors: Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., Jovinge, S., & Frisén, J.
Affiliations: Lyon 1 Université (FR)
Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Corresponding author: Bergmann, Olaf
Bhardwaj, Ratan D.
ORCID: Bergmann, Olaf
Bernard, Samuel
Alkass, Kanar
Buchholz, Bruce A.
Druid, Henrik
Jovinge, Stefan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-04-03
Volume: 324
Issue: 5923
Pages: 98-102
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1164680
PMC: PMC2991140
OpenAlex: W2101986300
Cited by: 3,130
References: 29
Citations by year: 2026: 85 · 2025: 128 · 2024: 150 · 2023: 145 · 2022: 193 · 2021: 204 · 2020: 178 · 2019: 184 · 2018: 185 · 2017: 224 · 2016: 209 · 2015: 222 · 2014: 232 · 2013: 207 · 2012: 211
FWCI: 77.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: National Institute of General Medical Sciences (P41GM103483)
National Center for Research Resources (RR13461, P41RR013461)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: cardiomyocyte renewal, cardiomyocyte turnover, cellular aging, bomb carbon-14, human heart, cardiac regeneration, cardiac pathology
MeSH terms: Adult, Aged, Aging, Carbon Radioisotopes, Cell Count, Cell Nucleus, Cell Separation, DNA, Humans, Middle Aged, Models, Cardiovascular, Polyploidy, Stem Cells, Echocardiography, Doppler, Color, Troponin I, Troponin T, Myocytes, Cardiac, Cell Nucleus Division, Cell Proliferation, Nuclear Weapons, Radiometric Dating

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for Cardiomyocyte Renewal in Humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks