Cited by 3,130Congenital heart defects researchNeurogenesis and neuroplasticity mechanismsMesenchymal stem cell research

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Evidence for Cardiomyocyte Renewal in Humans

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Bergmann, Olaf, Bhardwaj, Ratan D., Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A., Druid, Henrik, Jovinge, Stefan, Frisén, Jonas·2009·Science

DOI 10.1126/science.1164680PMC PMC2991140

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Abstract

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

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Authors: Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., Jovinge, S., & Frisén, J.
Affiliations: Lyon 1 Université (FR)
Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Corresponding author: Bergmann, Olaf
Bhardwaj, Ratan D.
ORCID: Bergmann, Olaf
Bernard, Samuel
Alkass, Kanar
Buchholz, Bruce A.
Druid, Henrik
Jovinge, Stefan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-04-03
Volume: 324
Issue: 5923
Pages: 98-102
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1164680
PMC: PMC2991140
OpenAlex: W2101986300
Cited by: 3,130
References: 29
Citations by year: 2026: 85 · 2025: 128 · 2024: 150 · 2023: 145 · 2022: 193 · 2021: 204 · 2020: 178 · 2019: 184 · 2018: 185 · 2017: 224 · 2016: 209 · 2015: 222 · 2014: 232 · 2013: 207 · 2012: 211
FWCI: 77.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: National Institute of General Medical Sciences (P41GM103483)
National Center for Research Resources (RR13461, P41RR013461)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: cardiomyocyte renewal, cardiomyocyte turnover, cellular aging, bomb carbon-14, human heart, cardiac regeneration, cardiac pathology
MeSH terms: Adult, Aged, Aging, Carbon Radioisotopes, Cell Count, Cell Nucleus, Cell Separation, DNA, Humans, Middle Aged, Models, Cardiovascular, Polyploidy, Stem Cells, Echocardiography, Doppler, Color, Troponin I, Troponin T, Myocytes, Cardiac, Cell Nucleus Division, Cell Proliferation, Nuclear Weapons, Radiometric Dating

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