The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structure of a Type IV Secretion System Core Complex
Open accessAbstract
Type IV secretion systems (T4SSs) are important virulence factors used by Gram-negative bacterial pathogens to inject effectors into host cells or to spread plasmids harboring antibiotic resistance genes. We report the 15 angstrom resolution cryo–electron microscopy structure of the core complex of a T4SS. The core complex is composed of three proteins, each present in 14 copies and forming a ∼1.1-megadalton two-chambered, double membrane–spanning channel. The structure is double-walled, with each component apparently spanning a large part of the channel. The complex is open on the cytoplasmic side and constricted on the extracellular side. Overall, the T4SS core complex structure is different in both architecture and composition from the other known double membrane–spanning secretion system that has been structurally characterized.
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Cites
Lateral gene transfer and the nature of bacterial innovation
Ochman, H., Lawrence, J. G., & Groisman, E. A. (2000) · Nature · doi:10.1038/35012500 · Cited by 3,816
The genome sequence of Rickettsia prowazekii and the origin of mitochondria
Andersson, S. G. E., Zomorodipour, A., Andersson, J. O., Sicheritz-Pontén, T., Alsmark, U. C. M., Podowski, R. M., Näslund, A. K., Eriksson, A.-S., Winkler, H. H., & Kurland, C. G. (1998) · Nature · doi:10.1038/24094 · Cited by 1,697
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
Ye, Y., Meyer, H. H., & Rapoport, T. A. (2001) · Nature · doi:10.1038/414652a · Cited by 1,099
Cited by
Secretion systems in Gram-negative bacteria: Structural and mechanistic insights
Costa, T. R. D., Felisberto-Rodrigues, C., Meir, A., Prevost, M. S., Redzej, A., Trokter, M., & Waksman, G. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3456 · Cited by 1,132
Self-citationBiological Diversity of Prokaryotic Type IV Secretion Systems
Alvarez-Martinez, C. E., & Christie, P. J. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00023-09 · Cited by 729
Integrative and Conjugative Elements (ICEs): What They Do and How They Work
Johnson, C. M., & Grossman, A. D. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-112414-055018 · Cited by 605
Wallden, K., Rivera-Calzada, A., & Waksman, G. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01499.x · Cited by 344
Self-citationAgrobacterium-Mediated Plant Transformation: Biology and Applications
Hwang, H.-H., Yu, M., & Lai, E.-M. (2017) · The Arabidopsis Book · doi:10.1199/tab.0186 · Cited by 312
Metadata
- Authors
- Fronzes, R., Schäfer, E., Wang, L., Saibil, H. R., Orlova, E. V., & Waksman, G.
- Venue
- Science
- Published
- 2009-01-09
- Volume
- 323
- Issue
- 5911
- Pages
- 266-268
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053552108
- Cited by
- 308
- References
- 3
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- green
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