The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories
Open accessAbstract
Reversing Pavlov: Memories of fearful associations, such as hearing a tone before receiving a low-voltage shock, are labile when they are retrieved, such that the association can be extinguished or reconsolidated. Monfils et al. (p. 951 , published online 2 April) demonstrate that applying a standard extinction treatment (sounding the tone multiple times in the absence of any shocks) within a window of time during which reconsolidation would normally occur has the effect of overwriting the original memory. Rats treated in this fashion display much lower levels of renewal (fear induced by sounding the tone once by itself), reinstatement (fear induced by giving the shock once by itself), and spontaneous recovery.
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In the citing paper
“a time gap of a few minutes may be needed between a retrieval cue and a blockade (figure 3), to allow a memory to destabilize (e.g. [88]).”
From Multiple memory systems, multiple time points: How science can inform treatment to control the expression of unwanted emotional memories (2018) · cites this paper as [88]
In the citing paper
“extinction learning within this window may diminish conditioned defensive responses more persistently than normal extinction learning, as the safety information has become part of the original fear memory [88].”
From Multiple memory systems, multiple time points: How science can inform treatment to control the expression of unwanted emotional memories (2018) · cites this paper as [88]
In the citing paper
“The first studies that translated findings in non-human animals [48,88,89] to humans used classical aversive conditioning to induce a simple emotional memory [94,95].”
From Multiple memory systems, multiple time points: How science can inform treatment to control the expression of unwanted emotional memories (2018) · cites this paper as [88]
In the citing paper
“However, other experimental studies have found effects of memory modification extending from one reactivated element to other elements of a compound memory [74], to similar—but not identical—stimuli, including imagined threat events [76,77], and to persist across contexts [77,88].”
From Multiple memory systems, multiple time points: How science can inform treatment to control the expression of unwanted emotional memories (2018) · cites this paper as [88]
In the citing paper
“Monfils and colleagues showed that retrieval + extinction effectively attenuated the return of fear through renewal or reinstatement (33).”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [33]
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Citations
Cites
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
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Wolpe, J. (1969) · Cited by 2,343
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Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,782
Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
Suzuki, A., Josselyn, S. A., Frankland, P. W., Masushige, S., Silva, A. J., & Kida, S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-03.2004 · Cited by 1,127
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Beyond extinction: erasing human fear responses and preventing the return of fear
Kindt, M., Soeter, M., & Vervliet, B. (2009) · Nature Neuroscience · doi:10.1038/nn.2271 · Cited by 826
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Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775
Self-citationReinstatement of fear to an extinguished conditioned stimulus.
Rescorla, R. A., & Heth, C. D. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.1.1.88 · Cited by 768
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Research works printed but not linked: 2
- I. V. Pavlov Conditioned Reflexes G. V. Anrep Trans. (Liveright New York 1927).
- 10.1101/lm.909208 · DOI
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Maximizing exposure therapy: An inhibitory learning approach
Craske, M. G., Treanor, M., Conway, C. C., Zbozinek, T., & Vervliet, B. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.04.006 · Cited by 2,339
From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466
Drug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225
Preventing the return of fear in humans using reconsolidation update mechanisms
Schiller, D., Monfils, M.-H., Raio, C. M., Johnson, D. C., LeDoux, J. E., & Phelps, E. A. (2010) · Nature · doi:10.1038/nature08637 · Cited by 1,248
Self-citation
Metadata
- Authors
- Monfils, M.-H., Cowansage, K. K., Klann, E., & LeDoux, J. E.
- Affiliations
- New York University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Monfils, Marie-H.
- Venue
- Science
- Published
- 2009-05-15
- Volume
- 324
- Issue
- 5929
- Pages
- 951-955
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3625935
- OpenAlex
- W2060160772
- Cited by
- 960
- References
- 36
- Citations by year
- 2026: 26 · 2025: 48 · 2024: 38 · 2023: 44 · 2022: 50 · 2021: 47 · 2020: 61 · 2019: 56 · 2018: 71 · 2017: 80 · 2016: 57 · 2015: 75 · 2014: 79 · 2013: 79 · 2012: 65
- FWCI
- 23.87
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH038774, P50MH058911, F31MH083472, K05MH067048, R01MH046516, R01MH091147)
- National Institute of Neurological Disorders and Stroke (NS-047384, NS-034007, R01NS047384)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- fear memory, extinction, reconsolidation blockade, memory reconsolidation, memory retrieval, fear extinction, fear conditioning, traumatic memory, rats
- MeSH terms
- Amygdala, Animals, Conditioning, Classical, Extinction, Psychological, Fear, Male, Memory, Phosphorylation, Mental Recall, Receptors, AMPA, Rats
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