Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

Yun, Jihye, Rago, Carlo, Cheong, Ian, Pagliarini, Ray, Angenendt, Philipp, Rajagopalan, Harith, Schmidt, Kerstin, Willson, James K. V., Markowitz, Sandy, Zhou, Shibin, Diaz, Luis A., Velculescu, Victor E., Lengauer, Christoph, Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas·2009·Science

DOI 10.1126/science.1174229

Cited by (910)

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Ran Chen, Cuihong Ma, Haoran Qian, Xinyu Xie, Yuxue Zhang, Dayun Lu, Shunjie Hu, Mao Zhang, Fen Liu, Yanmei Zou et al. · 2025 · Cancer Research
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Tianxiang Wang, Min Zhang, Xinyu Gong, Wanjing Chen, Ying Peng, Chenzhong Liao, Hongmei Xu, Qingshan Li, Guodong Shen, Huirong Ren et al. · 2024 · iScience
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Takaoki Furukawa, Yoshihiro Miyata, Kei Kushitani, Takahiro Mimae, Yasuhiro Tsutani, Yukio Takeshima, Morihito Okada · 2015 · Japanese Journal of Clinical Oncology
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Xiaobo Li, Xue Qian Gong, Xiaoning Peng, Sihua Peng · 2014 · International Journal of Multimedia and Ubiquitous Engineering
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Kefeng Lei, Ran Sun, Lee H. Chen, Bill H. Diplas, Casey J. Moure, Wenzhe Wang, Landon John Hansen, Yulei Tao, Xufeng Chen, Chin-Pu Jason Chen et al. · 2018 · Scientific Reports
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Yingke He, John Ong, Sharon G. K. Ong · 2018 · The Journal of Critical Care Medicine
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Agata N. Burska, Bayansulu Ilyassova, Aruzhan Dildabek, Medina Khamijan, Динара Бегимбетова, Ferdinand Molnár, Dos D. Sarbassov · 2022 · Cells
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Guangyao Li, Changhai Lei, Shi Hu · 2023 · Elsevier eBooks
Mannose-functionalized star polycation mediated CRISPR/Cas9 delivery for lung cancer therapy
Yu Wang, Yu Qi, Xindong Guo, Kai Zhang, Bingran Yu, Fu‐Jian Xu · 2023 · Journal of Materials Chemistry B
Monocarboxylate transporter 1
Andrew P. Halestrap · 2009 · AfCS-Nature Molecule Pages
Anticancer Strategy Targeting Mitochondrial Biogenesis in Ovarian Cancer
Md. Hafiz Uddin · 2014 · Journal of Cancer Science & Therapy
Cross-species analysis of genetically engineered mouse models of MAPK driven colorectal cancer identifies hallmarks of human disease
Peter J. Belmont, Eva Budínská, Ping Jiang, Mark J. Sinnamon, Erin M. Coffee, Jatin Roper, Tao Xie, Paul A. Rejto, Sahra Derkits, Owen James Sansom et al. · 2014 · Disease Models & Mechanisms
Diabetes, diabetes therapies and cancer: what’s the link?
Jason Seewoodhary, Stephen Charles Bain · 2011 · The British Journal of Diabetes
RAS status in Korean patients with stage III and IV colorectal cancer
W.-S. Lee, J. N. Lee, Jeong‐Heum Baek, Y. H. Park · 2015 · Clinical & Translational Oncology
Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene
Yong Teng, Lambert C. M. Ngoka, John Kenneth Cowell · 2017 · Genes Chromosomes and Cancer
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Kristian Larson, Radhamani Kannaiyan, Ritu Pandey, Yuliang Chen, Hani M. Babiker, Daruka Mahadevan · 2020 · Cancers
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Zufeng Guo, Zhiqiang Cheng, Jingxin Wang, Wukun Liu, Hanjing Peng, Yuefan Wang, Alka Rao, Ruo‐jing Li, Xue Ying, Preethi C. Korangath et al. · 2019 · Angewandte Chemie
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David González, Ana-Alejandra Gripo, Ana-Beatriz Rodríguez, Lourdes Franco · 2023 · Applied Sciences
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Andrew Oustimov, Vincent Q. Vu · 2014 · Translational Cancer Research
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Environmental Determinants of Ferroptosis in Cancer
Yasaman Setayeshpour, Yunji Lee, Jen‐Tsan Chi · 2023 · Cancers
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Ahmed M. Abou‐Shanab, Shaimaa Shouman, Alaa E. Hussein, Ola A. Gaser, Shireen Magdy, Eman Ashraf, Radwa Ayman Salah, Omaima Idris, Nagwa El‐Badri · 2025 · BMC Cancer
The signalling mechanisms of a novel mitochondrial complex I inhibitor prevent lipid accumulation and attenuate TNF-α-induced insulin resistance in vitro
Siobhán Leonard, Laura M. Tobin, John B. C. Findlay · 2017 · European Journal of Pharmacology
Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis
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KRAS mutation effects on the 2-[18F]FDG PET uptake of colorectal adenocarcinoma metastases in the liver
Marko M. Popovic, O. S. Talarico, Jörg van den Hoff, Henry S. Kunin, Z. Zhang, Daniel Lafontaine, Snjezana Doğan, Joanne Leung, Elena Kaye, Christian Czmielewski et al. · 2020 · EJNMMI Research