Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

Yun, Jihye, Rago, Carlo, Cheong, Ian, Pagliarini, Ray, Angenendt, Philipp, Rajagopalan, Harith, Schmidt, Kerstin, Willson, James K. V. +8 more·2009·Science

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  14. Epigenetic linkage of aging, cancer and nutrition
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  19. GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer
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  28. The harsh microenvironment in early breast cancer selects for a Warburg phenotype
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  29. Metabolic features of cancer stem cells: the emerging role of lipid metabolism
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  31. Ketosis and the Ketogenic Diet, 2010: Advances in Treating Epilepsy and Other Disorders
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  43. MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival
    Lee, Chih-Shia, Lee, Liam C., Yuan, Tina L., Chakka, Sirisha, Fellmann, Christof, Lowe, Scott W., Caplen, Natasha J., McCormick, Frank, Luo, Ji · 2019 · Proceedings of the National Academy of Sciences
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  45. Coupling of Glucose Deprivation with Impaired Histone H2B Monoubiquitination in Tumors
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  46. The sweet trap in tumors: aerobic glycolysis and potential targets for therapy
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  50. Glucose Metabolism in Pancreatic Cancer
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  66. Tumor metabolism as modulator of immune response and tumor progression
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  67. Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation
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  69. Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy
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  71. Epigenetic mechanisms and the hallmarks of cancer: an intimate affair.
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  72. Glucose deprivation–induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma
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  78. Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms
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  79. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling
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  80. Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
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  81. Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation
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  82. Canagliflozin inhibits growth of hepatocellular carcinoma via blocking glucose-influx-induced β-catenin activation
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  85. G6PD: A hub for metabolic reprogramming and redox signaling in cancer
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  86. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
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  87. MEK1/2 Inhibitors AS703026 and AZD6244 May Be Potential Therapies for <i>KRAS</i> Mutated Colorectal Cancer That Is Resistant to EGFR Monoclonal Antibody Therapy
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  88. Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome
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  89. Role of [18F]FDG PET in prediction of KRAS and EGFR mutation status in patients with advanced non-small-cell lung cancer
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  90. Metabolic reprograming of tumor-associated macrophages
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  91. Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia
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  92. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
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  93. Cerebral gluconeogenesis and diseases
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    Shanmugasundaram Ganapathy‐Kanniappan, Rani Kunjithapatham, Jean-François H. Geschwind · 2012 · Oncotarget
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  99. Transcriptional Regulation of Energy Metabolism in Cancer Cells
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