Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

Mutations of the BRAF gene in human cancer

Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857

ras oncogenes in human cancer: a review.

Bos, J. L. (1989) · PubMed · Cited by 5,061

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784

Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346

Targeting RAS signalling pathways in cancer therapy

Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,354

Cancer cell metabolism: warburg and beyond

Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452

PI3K pathway alterations in cancer: variations on a theme

Yuan, T. L., & Cantley, L. C. (2008) · Oncogene · doi:10.1038/onc.2008.245 · Cited by 1,845

Impact of acetylation on tumor metabolism

Zhao, D., Li, F.-L., Cheng, Z., & Lei, Q. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.963452 · Cited by 24

Regulating the effects of GPR21, a novel target for type 2 diabetes

Leonard, S., Kinsella, G. K., Benetti, E., & Findlay, J. B. C. (2016) · Scientific Reports · doi:10.1038/srep27002 · Cited by 23

Relationship between KRAS mutations and dual time point 18F-FDG PET/CT imaging in colorectal liver metastases

Mao, W., Zhou, J. F., Zhang, H., Qiu, L., Tan, H., Hu, Y., & Shi, H. (2018) · Abdominal Radiology · doi:10.1007/s00261-018-1740-8 · Cited by 23

Diagnostic performance of F-18 FDG PET/CT for prediction of KRAS mutation in colorectal cancer patients: a systematic review and meta-analysis

Kim, S., Pak, K., & Kim, K. (2019) · Abdominal Radiology · doi:10.1007/s00261-018-01891-3 · Cited by 23

Metformin May Be Associated with False-Negative Cancer Detection in the Gastrointestinal Tract on Pet/Ct

Steenkamp, D., McDonnell, M. E., & Meibom, S. K. (2014) · Endocrine Practice · doi:10.4158/ep14127.ra · Cited by 23

PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1

Yuan, M., Zhang, C., Chen, S., Ye, S., Liu, H., Ke, H., Huang, J., Liang, G., Yu, R., Hu, T., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217007 · Cited by 22

Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells

Hirschi, B., Gallmeier, E., Ziesch, A., Marschall, M. K., & Kolligs, F. T. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-122 · Cited by 22

Single-Cell Analysis of [18F]Fluorodeoxyglucose Uptake by Droplet Radiofluidics

Türkcan, S. C., Nguyen, J., Vilalta, M., Shen, B., Chin, F. T., Pratx, G., & Abbyad, P. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00792 · Cited by 22

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumors

Ludikhuize, M. C., Gevers, S., Nguyen, N. B., Meerlo, M., Roudbari, S. K. S., Gülersönmez, M. C., Stigter, E. C. A., Drost, J., Clevers, H. C., Burgering, B. M. T., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04055-8 · Cited by 23

On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects

Marcucci, F., & Rumio, C. (2023) · Cells · doi:10.3390/cells12081124 · Cited by 23

Tackling triple negative breast cancer with HDAC inhibitors: 6 is the isoform!

Guadagni, A., Barone, S., Alfano, A. I., Pelliccia, S., Bello, I., Panza, E., Summa, V., & Brindisi, M. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116884 · Cited by 22

The consequences of enhanced cell-autonomous glucose metabolism

Locasale, J. W. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.07.005 · Cited by 22

The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer

Forsythe, N., Refaat, A., Javadi, A., Khawaja, H. A., Weir, J.-A., Emam, H., Allen, W. L., Burkamp, F., Popovici, V. C., Jithesh, P. V., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0603 · Cited by 22

Influence of dual‐specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles

Zhang, H., Zhang, C., Liu, Y., Gao, W., Wang, S., Fang, X., Guo, Y., Li, M., Liu, R., Roman, R. J., et al. (2020) · Physiological Reports · doi:10.14814/phy2.14345 · Cited by 22

Correlation between KRAS mutation and 18F-FDG uptake in stage IV colorectal cancer

Cho, A. E.-H., Jo, K., Hwang, S. H., Lee, N., Jung, M., Yun, M., & Hwang, H. S. (2017) · Abdominal Radiology · doi:10.1007/s00261-017-1054-2 · Cited by 22

Metabolic Constrains Rule Metastasis Progression

Roda, N., Gambino, V., & Giorgio, M. (2020) · Cells · doi:10.3390/cells9092081 · Cited by 22

Facile preparation of Fe 3 O 4 @Pt nanoparticles as peroxidase mimics for sensitive glucose detection by a paper-based colorimetric assay

He, Y., Wang, P., Chen, X., Li, Y., Wei, J., Cai, G., Aoyagi, K., & Wang, W. (2022) · Royal Society Open Science · doi:10.1098/rsos.220484 · Cited by 21

Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype

Aprile, M., Cataldi, S., Perfetto, C., Federico, A., Ciccodicola, A., & Costa, V. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02282-2 · Cited by 21

The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?

Lv, J., Wang, J., Chang, S., Liu, M., & Pang, X. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv102 · Cited by 22

Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells

Hara, T., Jones, M. F., Subramanian, M., Li, X. L., Ou, O. L., Zhu, Y. J., Yang, Y.-A., Wakefield, L. M., Hussain, S. P., Gaedcke, J., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2284 · Cited by 21

Combination therapy targeting cancer metabolism

Wenger, J. B., Chun, S. Y., Dang, D. T., Luesch, H., & Dang, L. H. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.09.008 · Cited by 21

Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells

Davidescu, M., Sciaccaluga, M., Macchioni, L., Angelini, R., Lopalco, P., Rambotti, M. G., Roberti, R., Corcelli, A., Castigli, E., & Corazzi, L. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9411-x · Cited by 21

K-Ras and mitochondria: Dangerous liaisons

Neužil, J., Rohlena, J., & Dong, L. (2011) · Cell Research · doi:10.1038/cr.2011.160 · Cited by 21

Recently Identified and Potential Targets for Colon Cancer Treatment

Lea, M. A. (2010) · Future Oncology · doi:10.2217/fon.10.53 · Cited by 21

Molecular Mechanisms of Colorectal Carcinogenesis

Roper, J., & Hung, K. E. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8412-7_2 · Cited by 22

NK cell count and glucotransporter 4 (GLUT4) expression in subjects with type 2 diabetes and colon cancer

Piątkiewicz, P., Bernat-Karpińska, M., Miłek, T., Rabijewski, M., & Rosiak, E. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0152-6 · Cited by 21

Associations between physical activity and comorbidities in Korean cancer survivors

Kang, D., Lee, E., An, K. Y., Min, J., Jeon, J. Y., & Courneya, K. S. (2018) · Journal of Cancer Survivorship · doi:10.1007/s11764-018-0683-y · Cited by 21

Leveraging and manufacturing in vitro multicellular spheroid-based tumor cell model as a preclinical tool for translating dysregulated tumor metabolism into clinical targets and biomarkers

Wang, T., Wang, L., Wang, G., & Zhuang, Y. (2020) · Bioresources and Bioprocessing · doi:10.1186/s40643-020-00325-7 · Cited by 21

Metformin Attenuates Osteoporosis in Diabetic Patients with Carcinoma in Situ: A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

Lu, C., Chung, C., Kuo, F.-C., Chen, K.-C., Chang, C., Kuo, C., Lee, C.-H., Su, S., Liu, J., Lin, F., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092839 · Cited by 21

Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade

Benzarti, M., Delbrouck, C., Neises, L., Kiweler, N., & Meiser, J. (2020) · Cells · doi:10.3390/cells9092035 · Cited by 21

Revisiting lactate dynamics in cancer—a metabolic expertise or an alternative attempt to survive?

Mendes, C., & Serpa, J. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01965-0 · Cited by 20

Inhibition of SLC1A5 sensitizes colorectal cancer to cetuximab

Ma, Z., Li, T. X., Fu, W., Lei, C., & Hu, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821584-5.00023-7 · Cited by 20

The metabolic switch and its regulation in cancer cells

Zhou, S., Huang, C., & Wei, Y. (2010) · Science China Life Sciences · doi:10.1007/s11427-010-4041-1 · Cited by 21

Metabolism and cancer: an up-to-date review of a mutual connection.

Mentis, A. A., & Kararizou, E. G. (2010) · PubMed · Cited by 20

Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation

He, Q., Minn, I., Wang, Q., Xu, P. H., Head, S. A., Datan, E., Yu, B., Pomper, M. G., & Liu, J. O. (2016) · Angewandte Chemie · doi:10.1002/ange.201606121 · Cited by 20

Cancer: evolutionary, genetic and epigenetic aspects

Lichtenstein, A. V. (2010) · Clinical Epigenetics · doi:10.1007/s13148-010-0010-6 · Cited by 20

T cell adaptation in chronic infections and tumors

Luxenburger, H., Thimme, R., & Hofmann, M. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01405-y · Cited by 20

Oxidative DNA damage drives carcinogenesis in MUTYH-associated-polyposis by specific mutations of mitochondrial and MAPK genes

Venesio, T., Balsamo, A., Errichiello, E., Ranzani, G. N., & Risio, M. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.66 · Cited by 19

Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical Cancer Cells Through the FRA1/MDM2/p53 Pathway

Jiang, X., Yuan, J. T., Dou, Y., Zeng, D. X., & Xiao, S. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.47360 · Cited by 19

The Valley-of-Death: Reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment

Chiotti, K., Kvitek, D. J., Schmidt, K. H., Koniges, G., Schwartz, K., Donckels, E. A., Rosenzweig, F., & Sherlock, G. (2014) · Genomics · doi:10.1016/j.ygeno.2014.10.011 · Cited by 21

Genetics of Bladder Malignant Tumors in Childhood

Zangari, A., Zaini, J., & Gulìa, C. (2015) · Current Genomics · doi:10.2174/1389202916666151014221954 · Cited by 19

The Intricate Metabolism of Pancreatic Cancers

Camelo, F., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_5 · Cited by 19

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities

Pemovska, T., Bigenzahn, J. W., Srndic, I., Lercher, A., Bergthaler, A., César‐Razquin, A., Kartnig, F., Kornauth, C., Valent, P., Staber, P. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27329-x · Cited by 19

Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14

McCracken, A. N., & Edinger, A. L. (2015) · Biochemical Journal · doi:10.1042/bj20150721 · Cited by 19

Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications

Liu, S., Ma, Q., Zeng, C., Li, H., Su, J., Song, Z., Yan, R., Zhao, Z., Tian, S., & Huang, W. (2025) · Biomarker Research · doi:10.1186/s40364-025-00824-9 · Cited by 23

Genome Engineering Using Adeno-Associated Virus (AAV)

Howes, R., & Schofield, C. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1862-1_5 · Cited by 18

Chemoresistance in pancreatic ductal adenocarcinoma: Overcoming resistance to therapy

Bhoopathi, P., Mannangatti, P., Das, S. K., Fisher, P. B., & Emdad, L. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.010 · Cited by 19

Analytical metabolomics-based approaches to pancreatic cancer

Gangi, I. M. D., Vrhovšek, U., Pazienza, V., & Mattivi, F. (2014) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2013.12.006 · Cited by 18

Modeling Cancer in the CRISPR Era

Ventura, A., & Dow, L. E. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050455 · Cited by 18

MCT1, MCT4 and CD147 expression and 3-bromopyruvate toxicity in colorectal cancer cells are modulated by the extracellular conditions

Pereira-Vieira, J., Azevedo‐Silva, J., Preto, A., Casal, M., & Queirós, O. (2019) · Biological Chemistry · doi:10.1515/hsz-2018-0411 · Cited by 18

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

(2020) · doi:10.1242/jcs.239277 · Cited by 18

LncRNA NBR2 aggravates hepatoblastoma cell malignancy and promotes cell proliferation under glucose starvation through the miR-22/TCF7 axis

Zhu, C., He, X., Chen, K., Huang, Z., Yao, A., Tian, X., You, Y., & Zeng, M. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1885236 · Cited by 18

Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras

Velho, S., & Haigis, K. M. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.06.002 · Cited by 18

Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature

Lim, D. C., Brady, D. C., Soans, R. E., Kim, E., Valverde, L. B., Keenan, B. T., Guo, X., Kim, W. Y., Park, M., Galante, R. J., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01040.2015 · Cited by 18

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

Chattopadhyay, N., Berger, A., Koenig, E. M., Bannerman, B. M., Garnsey, J., Bernard, H., Hales, P., Lopez, A. M., Yu, Y., Donelan, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144825 · Cited by 18

Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor MicroenvironmentPreprint

Strelez, C., Perez, R. G., Chlystek, J. S., Cherry, C., Yoon, A. Y., Haliday, B., Shah, C. A., Ghaffarian, K., Sun, R., Jiang, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.14.557797 · Cited by 18

Early FDG/PET Scanning as a Pharmacodynamic Marker of Anti-EGFR Antibody Activity in Colorectal Cancer

Krystal, G. W., Alesi, E. R., & Tatum, J. L. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0011 · Cited by 17

Targeting gallbladder cancer: a pathway based perspective

Baichan, P., Naicker, P., Devar, J., Smith, M., Candy, G. P., & Nweke, E. E. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05269-x · Cited by 17

Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells

Nishikawa, G., Kawada, K., Hanada, K., Maekawa, H., Itatani, Y., Miyoshi, H., Taketo, M. M., & Obama, K. (2022) · Cells · doi:10.3390/cells11203273 · Cited by 19

Orthogonally Engineered Bacteria Capture Metabolically Labeled Tumor Antigens to Improve the Systemic Immune Response in Irradiated Tumors

Xia, W., Feng, Z., Wang, Y., Lei, R., Zhou, Y., Zhuo, Y., Xie, R., Dong, H., Zhao, X., Guan, X., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c13320 · Cited by 18

Genome-wide association and sequencing studies on colorectal cancer

Wong, S. H., Sung, J. J. �., Chan, F. K. L., To, K. F., Ng, S. S. M., Wang, X., Yu, J. Q., & Wu, W. K. K. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.09.005 · Cited by 18

Ras and macropinocytosis: trick and treat

Zwartkruis, F. J. T., & Burgering, B. M. T. (2013) · Cell Research · doi:10.1038/cr.2013.79 · Cited by 17

Bayesian model of signal rewiring reveals mechanisms of gene dysregulation in acquired drug resistance in breast cancer

Azad, A., Lawen, A., & Keith, J. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173331 · Cited by 17

The Intestinal Tumour Microenvironment

Leman, J. K. H., Munoz‐Erazo, L., & Kemp, R. A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-36214-0_1 · Cited by 18

Uncovering the Metabolic Origin of Aspartate for Tumor Growth Using an Integrated Molecular Deactivator

Duan, R., Xu, Y., Zeng, X., Xu, J., Liang, L., Zhang, Z., Wang, Z., Jiang, X., Xing, B., Liu, B., et al. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c04520 · Cited by 17

KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer

Choi, S., Kim, J. K., Chen, C., Wu, C., Marco, M. R., Barriga, F. M., O’Rourke, K. P., Pelossof, R., Qu, X., Chang, Q., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0994 · Cited by 19

Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration

Peng, Q., Hao, L., Guo, Y., Zhang, Z., Ji, J.-M., Xue, Y., Liu, Y., Lu, J., Li, C.-G., & Shi, X. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i13.3989 · Cited by 18

GLUT1 is a highly efficient L-fucose transporter

Ng, B. G., Sosicka, P., Xia, Z., & Freeze, H. H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102738 · Cited by 17

Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells

Morgan, G., Molnár, E., Jones, R. F., Collard, T. J., Lane, J. D., Greenhough, A., Paraskeva, C., & Williams, A. C. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.4 · Cited by 17

A Trimodal Closomer Drug‐Delivery System Tailored with Tracing and Targeting Capabilities

Sarma, S. J., Khan, A. A., Goswami, L. N., Jalisatgi, S. S., & Hawthorne, M. F. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201602413 · Cited by 17

Selective elimination of neuroblastoma cells by synergistic effect of Akt kinase inhibitor and tetrathiomolybdate

Navrátilová, J., Karasová, M., Lánová, M. K., Moráňová, L., Budková, Z., Pachernı́k, J., Šmarda, J., & Beneš, P. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13106 · Cited by 17

Raising the iron curtain: Lactate's secret role in oxidative stress defense

Hensel, A., Váraljai, R., & Knauer, S. K. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103754 · Cited by 16

Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer

Mizuno, S., Seishima, R., Yamasaki, J., Hattori, K., Ogiri, M., Matsui, S., Shigeta, K., Okabayashi, K., Nagano, O., Li, L., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-03960-z · Cited by 16

Estimating Relative Changes of Metabolic Fluxes

Huang, L., Kim, D.-S., Liu, X., Myers, C. R., & Locasale, J. W. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003958 · Cited by 16

Minibrain-related kinase/dual-specificity tyrosine-regulated kinase 1B implication in stem/cancer stem cells biology

Kokkorakis, N., & Gaitanou, M. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1553 · Cited by 16

2-Deoxyglucose, an Inhibitor of Glycolysis, Enhances the Oncolytic Effect of Coxsackievirus

Vorobyev, P. O., Кочетков, Д. В., Chumakov, P. M., Zakirova, N. F., Zotova-Nefedorova, S., Василенко, К. В., Alekseeva, O. N., Kochetkov, S. N., Bartosch, B., Lipatova, A. V., et al. (2022) · Cancers · doi:10.3390/cancers14225611 · Cited by 16

Simple Monitoring of Gene Targeting Efficiency in Human Somatic Cell Lines Using the PIGA Gene

Karnan, S., Konishi, Y., Ota, A., Takahashi, M., Damdindorj, L., Hosokawa, Y., & Konishi, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047389 · Cited by 16

Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer

Dhar, D., Raina, K., Kant, R., Wempe, M. F., Serkova, N. J., Agarwal, C., & Agarwal, R. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz114 · Cited by 16

Genetic Mutations and Non-Coding RNA-Based Epigenetic Alterations Mediating the Warburg Effect in Colorectal Carcinogenesis

Zamer, B. A., Abumustafa, W., Hamad, M. A., Maghazachi, A. A., & Muhammad, J. S. (2021) · Biology · doi:10.3390/biology10090847 · Cited by 16

Oncology's energetic pipeline

Garber, K. (2010) · Nature Biotechnology · doi:10.1038/nbt0910-888 · Cited by 17

Exploring the metabolic signaling network of GFPT in cancer

Sampson, C., Li, P., Wang, Y., Liu, J., Lv, J., Xia, T., Piao, H., & Ma, Y. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02687-3 · Cited by 16

Rerouting the drug response: Overcoming metabolic adaptation in KRAS-mutant cancers

Moss, D., McCann, C. K., & Kerr, E. M. (2022) · Science Signaling · doi:10.1126/scisignal.abj3490 · Cited by 16

Dual-targeted NAMPT inhibitors as a progressive strategy for cancer therapy

Özgencil, F., Gunindi, H. B., & Eren, G. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107509 · Cited by 15

mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling

Masui, K., Shibata, N., Cavenee, W. K., & Mischel, P. S. (2016) · BioEssays · doi:10.1002/bies.201600026 · Cited by 15

Therapeutic Strategies Toward Lactate Dehydrogenase Within the Tumor Microenvironment of Pancreatic Cancer

Moir, J. A. G., Long, A. K., Haugk, B., French, J., Charnley, R., Manas, D., Wedge, S. R., Mann, J., Robinson, S. M., & White, S. A. (2020) · Pancreas · doi:10.1097/mpa.0000000000001689 · Cited by 15

Pretreatment 18F-FDG PET/CT Imaging Predicts the KRAS/NRAS/BRAF Gene Mutational Status in Colorectal Cancer

He, P., Zou, Y., Qiu, J., Yang, T., Peng, L., & Zhang, X. (2021) · Journal of Oncology · doi:10.1155/2021/6687291 · Cited by 16

Mycochemicals against Cancer Stem Cells

Tacchini, M., Sacchetti, G., Guerrini, A., & Paganetto, G. (2023) · Toxins · doi:10.3390/toxins15060360 · Cited by 15

Nanoscale materials and approaches for optical glucose assays

Xianyu, Y., & Jiang, X. (2014) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2014.01.009 · Cited by 15

Key indexes and the emerging tool for tumor microenvironment editing.

Dai, X., Luo, Y.-N., Xu, Y., & Zhang, J. (2019) · PubMed Central · Cited by 15

Design, synthesis, and biological evaluation of aryl piperazines with potential as antidiabetic agents via the stimulation of glucose uptake and inhibition of NADH:ubiquinone oxidoreductase

Devine, R., Kelada, M., Leonard, S., Martin, D. S. D., Walsh, J. M. D., Breen, C. J., Driver, R. B., Kinsella, G. K., Findlay, J. B. C., & Stephens, J. C. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112416 · Cited by 15

Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS

Rathore, M., Zhang, W., Wright, M., Bhattacharya, R., Fan, F., Vaziri-Gohar, A., Winter, J., Wang, Z., Markowitz, S. D., Willis, J., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0633 · Cited by 14

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

Ruan, H., Leibowitz, B. J., Peng, Y., Shen, L., Chen, L., Kuang, C., Schoen, R. E., Lu, X., Zhang, L., & Yu, J. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00070-7 · Cited by 14

Metformin combined with CB-839 specifically inhibits KRAS-mutant ovarian cancer

Wu, H., Zhang, J., Wang, Q., Li, Z., Li, L., & Xie, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-90963-8 · Cited by 14

Interplay between Epigenetics and Cellular Metabolism in Colorectal Cancer

Zhang, X., Dong, Z., & Cui, H. (2021) · Biomolecules · doi:10.3390/biom11101406 · Cited by 14

Azide based routes to tetrazolo and oxadiazolo derivatives of pyrrolobenzodiazepines and pyrrolobenzothiadiazepines

Hemming, K., Chambers, C. S., Hamasharif, M. S., João, H., Khan, M. N., Patel, N., Airley, R. E., & Day, S. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.07.050 · Cited by 14

Relationship between KRAS mutation and diffusion weighted imaging in colorectal liver metastases; Preliminary study

Gültekin, M. A., Türk, H. M., Beşiroğlu, M., Toprak, H., Yurtsever, İ., Yılmaz, T. F., Sharifov, R., & Uysal, Ö. (2020) · European Journal of Radiology · doi:10.1016/j.ejrad.2020.108895 · Cited by 14

Defeat mutant KRAS with synthetic lethality

Pang, X., & Liu, M. (2016) · Small GTPases · doi:10.1080/21541248.2016.1213783 · Cited by 14

Ruthenium Drug BOLD-100 Regulates BRAF MT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation

Griffin, D., Carson, R., Moss, D., Sessler, T., Lavin, D. P., Tiwari, V. K., Karelia, S., Kennedy, R. D., Savage, K. I., McDade, S. S., et al. (2024) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-24-0151 · Cited by 14

Parameters Estimation in Phase-Space Landscape Reconstruction of Cell Fate: A Systems Biology Approach

Montero, S., Martin, R., Mansilla, R., Cocho, G., & Nieto-Villar, J. M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7456-6_8 · Cited by 14

SUVmax and metabolic tumor volume: surrogate image biomarkers of KRAS mutation status in colorectal cancer

Lv, Y., Wang, X., Liang, L., Wang, L., & Lü, J. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s196725 · Cited by 13

Colon cancer may yield to cellular sugar starvation

(2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.17.10008

Abstract C60: Vitamin C inhibits the survival and growth of colorectal cancer cells with KRAS or BRAF mutations

Yun, J., Kavalier, A. R., Roper, J., Gross, S., Rago, C., Papadopoulos, N., Vogelstein, B., & Cantley, L. C. (2013) · Cancer Research · doi:10.1158/1538-7445.fbcr13-c60

Mutant KRAS Exosomes Influence the Metabolic State of the Colon Microenvironment

Preet, R., & Dixon, D. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.01.021 · Cited by 4

Desperately Seeking Glucose

Kiberstis, P. A. (2009) · Science Signaling · doi:10.1126/scisignal.289ec312

Abstract B32: Mutant KRAS downregulates LIFR to enhance glycolysis in pancreatic cancer

Liu, S., Gandler, H. I., Walker, S. R., Ye, D. Q., Giaccone, Z. T., Nowak, J. A., Aguirre, A. J., Wolpin, B. M., & Frank, D. A. (2019) · Cancer Research · doi:10.1158/1538-7445.panca19-b32