Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

Mutations of the BRAF gene in human cancer

Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857

ras oncogenes in human cancer: a review.

Bos, J. L. (1989) · PubMed · Cited by 5,061

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784

Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346

Targeting RAS signalling pathways in cancer therapy

Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,354

Cancer cell metabolism: warburg and beyond

Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452

PI3K pathway alterations in cancer: variations on a theme

Yuan, T. L., & Cantley, L. C. (2008) · Oncogene · doi:10.1038/onc.2008.245 · Cited by 1,845

Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome

Ayele, F. T., Doumatey, A. P., Shriner, D., Bentley, A. R., Chen, G., Zhou, J., Fasanmade, O. A., Johnson, T., Oli, J., Okafor, G., et al. (2015) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2015.10.008 · Cited by 53

A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy

Stebbing, J., Sharma, A., North, B. V., Athersuch, T. J., Zebrowski, A., Pchejetski, D., Coombes, R. C., Nicholson, J. K., & Keun, H. C. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr347 · Cited by 56

Inhibition of SLC1A 5 sensitizes colorectal cancer to cetuximab

Ma, H., Wu, Z., Peng, J., Li, Y., Huang, H., Liao, Y., Zhou, M., Sun, L., Huang, N., Shi, M., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31274 · Cited by 52

Targeting the RAS-dependent chemoresistance: The Warburg connection

Serna‐Blasco, R., Sanz-Álvarez, M., Aguilera, Ó., & García‐Foncillas, J. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.016 · Cited by 55

Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia

Jędraszek, K., Malczewska, M., Parysek-Wójcik, K., & Lejman, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063067 · Cited by 57

Molecular Pathways: Targeting the Dependence of Mutant RAS Cancers on the DNA Damage Response

Grabocka, E., Commisso, C., & Bar‐Sagi, D. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0650 · Cited by 53

Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis

Hovsepian, J., Defenouillère, Q., Albanèse, V., Váchová, L., Garcia, C., Palková, Z., & Sébastien Léon, A. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201610094 · Cited by 56

Immunometabolism: A new target for improving cancer immunotherapy

Guo, C., Chen, S., Liu, W., Ma, Y., Li, J., Fisher, P. B., Fang, X., & Wang, X. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.03.004 · Cited by 56

The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer

Alfarouk, K. O., Ahmed, S. B. M., Ahmed, A., Elliott, R. L., Ibrahim, M. E., Ali, H. S., Wales, C. C., Nourwali, I., Aljarbou, A. N., Bashir, A. H. H., et al. (2020) · Cancers · doi:10.3390/cancers12040898 · Cited by 52

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

Nelson, B. S., Lin, L., Kremer, D. M., Sousa, C. M., Cotta‐Ramusino, C., Myers, A. L., Ramos, J., Gao, T., Kovalenko, I., Wilder-Romans, K., et al. (2020) · Cancer & Metabolism · doi:10.1186/s40170-019-0202-2 · Cited by 51

Hypoxia-induced cysteine metabolism reprogramming is crucial for the tumorigenesis of colorectal cancer

Zhang, L., Yang, S., Qiu, Q., Cui, G., Zhang, Y., Yao, M., Li, X., Chen, C., Gu, J., Wang, T., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103286 · Cited by 53

Correlation of BRAFV600E Mutation and Glucose Metabolism in Thyroid Cancer Patients: An 18F-FDG PET Study

Nagarajah, J., Ho, A. L., Tuttle, R. M., Weber, W., & Grewal, R. K. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.150607 · Cited by 51

Cancer's insatiable appetite

Locasale, J. W., Cantley, L. C., & Heiden, M. G. V. (2009) · Nature Biotechnology · doi:10.1038/nbt1009-916 · Cited by 51

Cancer Risk in Type 2 Diabetes Mellitus: Metabolic Links and Therapeutic Considerations

Sun, G. E. C., & Kashyap, S. R. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/708183 · Cited by 51

Targeting Cell Metabolism as Cancer Therapy

Ngoi, N. Y. L., Eu, J. Q., Hirpara, J. L., Wang, L., Lim, J. S. J., Lee, S. C., Lim, Y., Pervaiz, S., Goh, B. C., & Wong, A. L. A. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7947 · Cited by 52

The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer

Hon, K. W., Abidin, S. A. Z., Othman, I., & Naidu, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.768861 · Cited by 53

Harness the functions of gut microbiome in tumorigenesis for cancer treatment

Lee, M. (2021) · Cancer Communications · doi:10.1002/cac2.12200 · Cited by 50

Heterogeneity of glycolysis in cancers and therapeutic opportunities

Warmoes, M. O., & Locasale, J. W. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.019 · Cited by 50

Tumor-stromal interactions in pancreatic cancer

Tod, J., Jenei, V., Thomas, G. J., & Fine, D. R. (2013) · Pancreatology · doi:10.1016/j.pan.2012.11.311 · Cited by 49

MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells

Miniotis, M. F., Arunan, V., Eykyn, T. R., Marais, R., Workman, P., Leach, M. O., & Beloueche‐Babari, M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1969 · Cited by 49

Advances in glucose metabolism research in colorectal cancer

Fang, S., & Fang, X. (2016) · Biomedical Reports · doi:10.3892/br.2016.719 · Cited by 49

Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation

Lee, H., Jedrychowski, M. P., Vinayagam, A., Wu, N., Shyh‐Chang, N., Hu, Y., Min-Wen, C., Moore, J. K., Asara, J. M., Lyssiotis, C. A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.074 · Cited by 49

The multi-faceted functioning portrait of LRF/ZBTB7A

Constantinou, C., Σπέλλα, Μ., Chondrou, V., Patrinos, G. P., Papachatzopoulou, A., & Sgourou, A. (2019) · Human Genomics · doi:10.1186/s40246-019-0252-0 · Cited by 48

Interplay between Metabolism Reprogramming and Epithelial-to-Mesenchymal Transition in Cancer Stem Cells

Daniel, Y., Lelou, E., Aninat, C., Corlu, A., & Cabillic, F. (2021) · Cancers · doi:10.3390/cancers13081973 · Cited by 52

Glutamine at focus: versatile roles in cancer

Vitto, H. D., Pérez-Valencia, J. A., & Radosevich, J. A. (2015) · Tumor Biology · doi:10.1007/s13277-015-4671-9 · Cited by 54

Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays

Guo, Z., Cheng, Z., Wang, J., Liu, W., Peng, H., Wang, Y., Rao, A., Li, R., Ying, X., Korangath, P. C., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201905578 · Cited by 48

Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells

Satheesh, N. J., Samuel, S. M., & Büsselberg, D. (2020) · Biomolecules · doi:10.3390/biom10010079 · Cited by 53

Overexpression of GLUT1 in Colorectal Cancer is Independently Associated with Poor Prognosis

Shen, Y., Arbman, G., Olsson, B., & Sun, X. (2011) · The International Journal of Biological Markers · doi:10.5301/jbm.2011.8550 · Cited by 48

Colon tumour cells increase PGE2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation

Roberts, H. R., Smartt, H. J. M., Greenhough, A., Moore, A. E., Williams, A. C., & Paraskeva, C. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr210 · Cited by 48

From Images to Genes: Radiogenomics Based on Artificial Intelligence to Achieve Non‐Invasive Precision Medicine in Cancer Patients

Guo, Y., Li, T., Gong, B., Hu, Y., Wang, S., Yang, L., & Zheng, C. (2024) · Advanced Science · doi:10.1002/advs.202408069 · Cited by 49

Towards personalized medicine of colorectal cancer

Aziz, M. A., Yousef, Z., Saleh, A., Mohammad, S., & Knawy, B. A. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.08.007 · Cited by 47

Research progress on KRAS mutations in colorectal cancer

Cefalì, M., Epistolio, S., Palmarocchi, M. C., Frattini, M., & Dosso, S. D. (2021) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2021.61 · Cited by 48

Mitoplasticity: Adaptation Biology of the Mitochondrion to the Cellular Redox State in Physiology and Carcinogenesis

José, C., Melser, S., Bénard, G., & Rossignol, R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4357 · Cited by 51

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

Rosales, K. R., Singh, G., Wu, K. C. ‐., Chen, J., Janes, M. R., Lilly, M. B., Peralta, E. R., Siskind, L. J., Bennett, M. J., Fruman, D. A., et al. (2011) · Biochemical Journal · doi:10.1042/bj20110853 · Cited by 46

Host-Microbiome Interaction and Cancer: Potential Application in Precision Medicine

Contreras, A. V., Cocom-Chan, B., Hernández‐Montes, G., Portillo-Bobadilla, T., & Reséndis-Antonio, O. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00606 · Cited by 49

Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT

Kanska, J. E., Aspuria, P.-J. P., Taylor‐Harding, B., Spurka, L., Funari, V. A., Oršulić, S., Karlan, B. Y., & Wiedemeyer, W. R. (2017) · Oncotarget · doi:10.18632/oncotarget.15429 · Cited by 47

Cancer cell metabolism connects epigenetic modifications to transcriptional regulation

Morrison, A. J. (2021) · FEBS Journal · doi:10.1111/febs.16032 · Cited by 47

The role of KRAS splice variants in cancer biology

Nuevo‐Tapioles, C., & Philips, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1033348 · Cited by 48

A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

Chidley, C., Darnell, A. M., Gaudio, B. L., Lien, E. C., Barbeau, A. M., Heiden, M. G. V., & Sorger, P. K. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01402-1 · Cited by 45

Glutamine Deprivation Enhances Antitumor Activity of 3-Bromopyruvate through the Stabilization of Monocarboxylate Transporter-1

Cardaci, S., Rizza, S., Filomeni, G., Bernardini, R., Bertocchi, F., Mattei, M., Paci, M., Rotilio, G., & Ciriolo, M. R. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1741 · Cited by 45

Increased sensitivity of extracellular glucose monitoring based on AuNP decorated GO nanocomposites

Qi, M., Zhang, Y., Cao, C., Lü, Y., & Liu, G. (2016) · RSC Advances · doi:10.1039/c6ra04975c · Cited by 45

Energy metabolism in skin cancers: A therapeutic perspective

Hosseini, M., Kasraian, Z., & Rezvani, H. R. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.01.013 · Cited by 46

MicroRNAs in Oncogenesis and Tumor Suppression

Barbato, S., Solaini, G., & Fabbri, M. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.05.001 · Cited by 45

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

Zhang, Q., Jeppesen, D. K., Higginbotham, J. N., Beckler, M. D., Poulin, E. J., Walsh, A. J., Skala, M. C., McKinley, E. T., Manning, H. C., Hight, M. R., et al. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.01.013 · Cited by 45

Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function

Kattan, W. E., Chen, W., Ma, X., Lan, T.-H., van der Hoeven, D., van der Hoeven, R., & Hancock, J. F. (2019) · Life Science Alliance · doi:10.26508/lsa.201900431 · Cited by 46

A Comparative Analysis of Constitutive Promoters Located in Adeno-Associated Viral Vectors

Damdindorj, L., Karnan, S., Ota, A., Hossain, E., Konishi, Y., Hosokawa, Y., & Konishi, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106472 · Cited by 54

IFI16 Induction by Glucose Restriction in Human Fibroblasts Contributes to Autophagy through Activation of the ATM/AMPK/p53 Pathway

Duan, X., Ponomareva, L. V., Veeranki, S., & Choubey, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019532 · Cited by 46

Chromosomal instability causes sensitivity to metabolic stress

Shaukat, Z., Liu, D., Choo, A., Hussain, R., O’Keefe, L. V., Richards, R. I., Saint, R. B., & Gregory, S. L. (2014) · Oncogene · doi:10.1038/onc.2014.344 · Cited by 44

Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae

Bartölke, R., Heinisch, J. J., Wieczorek, H., & Vitavska, O. (2014) · Biochemical Journal · doi:10.1042/bj20140572 · Cited by 44

3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants

Konstantakou, E. G., Voutsinas, G. E., Velentzas, A. D., Bassogianni, A.-S., Paronis, E., Balafas, E., Kostomitsopoulos, N. G., Syrigos, K. N., Anastasiadou, E., & Stravopodis, D. J. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0399-9 · Cited by 44

Vitamin C in Cancer: A Metabolomics Perspective

Park, S., Ahn, S., Shin, Y., Yang, Y.-J., & Yeom, C. H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00762 · Cited by 44

A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties via Wnt/β‐catenin signaling

Hwang, J., Yoon, J., Cho, Y., Cha, P.-H., Park, J., & Choi, K. (2019) · International Journal of Cancer · doi:10.1002/ijc.32728 · Cited by 44

Flexibility and Adaptation of Cancer Cells in a Heterogenous Metabolic Microenvironment

Bluemel, G., Mondal, A., & Leithner, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031476 · Cited by 44

Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4

Guo, T., Bai, Y., Cheng, X., Han, H., Du, H., Hu, Y., Jia, S., Xing, X., & Ji, J. (2021) · 癌症：英文版 · doi:10.1002/cac2.12141 · Cited by 44

Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma

Xu, Y., Hao, X., Ren, Y., Xu, Q., Liu, X., Song, S., & Wang, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1063423 · Cited by 45

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate

Keenan, M. M., Liu, B., Tang, X., Wu, J., Cyr, D. D., Stevens, R. D., Ilkayeva, O., Huang, Z., Tollini, L. A., Murphy, S. K., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005599 · Cited by 43

Metabolic Signaling to Epigenetic Alterations in Cancer

Kim, J., & Yeom, Y. I. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.185 · Cited by 45

The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose

Li, X., Deng, S., Liu, M., Jin, Y., Zhu, S., Deng, S.-J., Chen, J., He, C., Qin, Q., Wang, C., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0158-5 · Cited by 44

Metabolic Imaging Phenotype Using Radiomics of [18F]FDG PET/CT Associated with Genetic Alterations of Colorectal Cancer

Chen, S.-W., Shen, W.-C., Chen, W. T., Hsieh, T., Yen, K., Chang, J., & Kao, C. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-018-1225-8 · Cited by 43

Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo

Takai, T., Tsujino, T., Yoshikawa, Y., Inamoto, T., Sugito, N., Kuranaga, Y., Heishima, K., Soga, T., Hayashi, K., Miyata, K., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.03.004 · Cited by 43

Perturbation of phosphoglycerate kinase 1 (PGK1) only marginally affects glycolysis in cancer cells

Jin, C., Zhu, X., Wu, H., Wang, Y., & Hu, X. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012312 · Cited by 42

Antitumor Effects in Gastrointestinal Stromal Tumors Using Photodynamic Therapy with a Novel Glucose-Conjugated Chlorin

Tanaka, M., Kataoka, H., Yano, S., Ohi, H., Moriwaki, K., Akashi, H., Taguchi, T., Hayashi, N., Hamano, S., Mori, Y., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0393 · Cited by 41

Cellular Internalization of Therapeutic Oligonucleotides by Peptide Amphiphile Nanofibers and Nanospheres

Mumcuoglu, D., Ekiz, M. Ş., Gunay, G., Tekinay, T., Tekinay, A. B., & Guler, M. O. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01526 · Cited by 41

Alteration of cellular metabolism in cancer cells and its therapeutic prospects

Biswal, B. N., Das, S., Das, B., & Rath, R. (2017) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_60_17 · Cited by 42

What ‘We’?

Lawford‐Smith, H. (2015) · Journal of Social Ontology · doi:10.1515/jso-2015-0008 · Cited by 44

Clinical impact of the Warburg effect in gastrointestinal cancer (Review)

Sawayama, H., Ishimoto, T., Sugihara, H., Miyanari, N., Miyamoto, Y., Baba, Y., Yoshida, N., & Baba, H. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2563 · Cited by 41

Impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification

Maki, Y., Soh, J., Ichimura, K., Shien, K., Furukawa, M., Muraoka, T., Tanaka, N., Ueno, T., Yamamoto, H., Asano, H., et al. (2012) · Oncology Reports · doi:10.3892/or.2012.2087 · Cited by 41

Inhibitors of glucose transport and glycolysis as novel anticancer therapeutics

Qian, Y. (2014) · World Journal of Translational Medicine · doi:10.5528/wjtm.v3.i2.37 · Cited by 41

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis

Ikeno, Y., Seo, S., Iwaisako, K., Yoh, T., Nakamoto, Y., Fuji, H., Taura, K., Okajima, H., Kaido, T., Sakaguchi, S., et al. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1475-x · Cited by 40

Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition

Nguyen, M. Q., Teh, J. L. F., Purwin, T. J., Chervoneva, I., Davies, M. A., Nathanson, K. L., Cheng, P. F., Levesque, M. P., Dummer, R., & Aplin, A. E. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.02.047 · Cited by 40

Oxymatrine Inhibits Colorectal Cancer Metastasis via Attenuating PKM2-Mediated Aerobic Glycolysis

Li, X., Sun, J., Xu, Q., Duan, W., Yang, L., Wu, X., Lu, G., Zhang, L., & Zheng, Y. (2020) · Cancer Management and Research · doi:10.2147/cmar.s267686 · Cited by 40

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

Ruan, H., Li, X., Xu, X. M., Leibowitz, B. J., Tong, J., Chen, L., Ao, L., Xing, W., Luo, J., Yu, Y., et al. (2020) · eLife · doi:10.7554/elife.60151 · Cited by 40

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma

Levy, A. G., Zage, P. E., Akers, L. J., Ghisoli, M. L., Chen, Z., Fang, W., Kannan, S., Graham, T. C., Zeng, L., Franklin, A. R. K., et al. (2010) · Investigational New Drugs · doi:10.1007/s10637-010-9551-y · Cited by 40

δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming

Nopparat, J., Zhang, J. H., Lu, J., Chen, Y.-H., Zheng, D., Neufer, P. D., Fan, J. M., Hong, H., Boykin, C., & Lu, Q. (2014) · Oncogene · doi:10.1038/onc.2014.89 · Cited by 40

The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities

Cordani, M., Michetti, F., Zarrabi, A., Zarepour, A., Rumio, C., Strippoli, R., & Marcucci, F. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101076 · Cited by 40

Single Copies of Mutant KRAS and Mutant PIK3CA Cooperate in Immortalized Human Epithelial Cells to Induce Tumor Formation

Wang, G. M., Wong, H. Y., Konishi, H., Blair, B. G., Abukhdeir, A. M., Gustin, J. P., Rosen, D. M., Denmeade, S. R., Rasheed, Z., Matsui, W., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1578 · Cited by 39

Hallmarks of cancer and hallmarks of aging

Blagosklonny, M. V. (2022) · Aging · doi:10.18632/aging.204082 · Cited by 43

Revisiting the biological role of the Warburg effect: Evolving perspectives on cancer metabolism

León-Oliva, D. D., González-Prieto, P., Castro-Martinez, P. D., Boaru, D. L., Hernandez, P. L., Fraile‐Μartinez, O., Montero, C. G., Guijarro, L. G., López-González, L., Díaz, R., et al. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156151 · Cited by 42

Enhanced Isolation of Fibroblasts from Human Skin Explants

Huschtscha, L. I., Napier, C. E., Noble, J. R., Bower, K., Au, A. Y. M., Campbell, H. G., Braithwaite, A. W., & Reddel, R. R. (2012) · BioTechniques · doi:10.2144/0000113939 · Cited by 39

Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy

Saigusa, S., Toiyama, Y., Tanaka, K., Okugawa, Y., Fujikawa, H., Matsushita, K., Uchida, K., Inoue, Y., & Kusunoki, M. (2011) · Surgery Today · doi:10.1007/s00595-011-0027-2 · Cited by 39

Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells.

(2015) · Europe PMC (PubMed Central) · Cited by 39

PPARδ promotes tumor progression via activation of Glut1 and SLC1-A5 transcription

Zhang, W., Xu, Y., Xu, Q., Shi, H., Shi, J., & Hou, Y. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx035 · Cited by 39

Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms

Fu, L.-N., Yq, W., Tan, J., Xu, J., Gao, Q.-Y., Chen, Y., & Fang, J.-Y. (2017) · Oncogene · doi:10.1038/onc.2017.345 · Cited by 39

Metabolome analysis reveals excessive glycolysis via PI3K/AKT/mTOR and RAS/MAPK signaling in methotrexate-resistant primary CNS lymphoma-derived cells

Takashima, Y., Hayano, A., & Yamanaka, R. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3851 · Cited by 39

Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines

Varshavi, D., Varshavi, D., McCarthy, N., Veselkov, K., Keun, H. C., & Everett, J. R. (2020) · Metabolomics · doi:10.1007/s11306-020-01674-2 · Cited by 41

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

Bellier, J., Nokin, M.-J., Caprasse, M., Tiamiou, A., Blomme, A., Scheijen, J. L., Koopmansch, B., MacKay, G. M., Chiavarina, B., Costanza, B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.012 · Cited by 38

Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer

Zhao, L., Deng, H., Zhang, J., Zamboni, N., Yang, H., Gao, Y., Zhang, Y., Xu, D., Zhong, H., van Geest, G., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01427-x · Cited by 43

From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer

Bathe, O. F., & Farshidfar, F. (2014) · Genes · doi:10.3390/genes5030536 · Cited by 39

Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma

Liang, C., Qin, Y., Zhang, B., Ji, S., Shi, S., Xu, W., Liu, J., Xiang, J., Liang, D., Hu, Q., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.09.001 · Cited by 39

Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications

Yu, C.-C., Qiu, W., Juang, C. S., MANSUKHANI, M. M., Halmos, B., & Su, G. H. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.10.013 · Cited by 38

Potential Therapies Targeting Metabolic Pathways in Cancer Stem Cells

Shen, Y., Chen, C.-C., Chen, B., Wu, Y.-T., Juan, J.-R., Chen, L.-Y., Teng, Y.-C., & Wei, Y. (2021) · Cells · doi:10.3390/cells10071772 · Cited by 38

Metabolome analysis for discovering biomarkers of gastroenterological cancer

Suzuki, M., Nishiumi, S., Matsubara, A., Azuma, T., & Yoshida, M. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.02.042 · Cited by 38

Monitoring circulating tumor DNA revealed dynamic changes inKRASstatus in patients with metastatic colorectal cancer

Takayama, Y., Suzuki, K., Muto, Y., Ichida, K., Fukui, T., Kakizawa, N., Ishikawa, H., Watanabe, F., Hasegawa, F., Saito, M., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25309 · Cited by 38

Dual Specificity Phosphatase 5‐Substrate Interaction: A Mechanistic Perspective

Kutty, R. G., Talipov, M. R., Bongard, R. D., Jones, R. A., Sweeney, N. L., Sem, D. S., Rathore, R., & Ramchandran, R. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170007 · Cited by 38

Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications

Halabi, I. E., Bejjany, R., Nasr, R., Mukherji, D., Temraz, S. N., Nassar, F. J., Darsa, H. E., & Shamseddine, A. I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092752 · Cited by 36

Advances in Lung Cancer Driver Genes Associated With Brain Metastasis

Kang, Y., Jin, Y. T., Li, Q., & Yuan, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.606300 · Cited by 37

Metabolic Strategies for Inhibiting Cancer Development

Icard, P., Loi, M., Wu, Z., Ginguay, A., Lincet, H., Robin, E., Coquerel, A., Berzan, D., Fournel, L., & Alifano, M. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa174 · Cited by 36

Nuclear receptors and the Warburg effect in cancer

Thorne, J. L., & Campbell, M. J. (2014) · International Journal of Cancer · doi:10.1002/ijc.29012 · Cited by 36

Mutant BRAF Induces DNA Strand Breaks, Activates DNA Damage Response Pathway, and Up-Regulates Glucose Transporter-1 in Nontransformed Epithelial Cells

Sheu, J. J., Guan, B., Tsai, F., Hsiao, E. Y.-T., Chen, C., Seruca, R., Wang, T., & Shih, I. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.026 · Cited by 37

L’effet Warburg

Razungles, J., Cavaillès, V., Jalaguier, S., & Teyssier, C. (2013) · médecine/sciences · doi:10.1051/medsci/20132911020 · Cited by 50

Colon cancer may yield to cellular sugar starvation

(2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.17.10008

Abstract C60: Vitamin C inhibits the survival and growth of colorectal cancer cells with KRAS or BRAF mutations

Yun, J., Kavalier, A. R., Roper, J., Gross, S., Rago, C., Papadopoulos, N., Vogelstein, B., & Cantley, L. C. (2013) · Cancer Research · doi:10.1158/1538-7445.fbcr13-c60

Mutant KRAS Exosomes Influence the Metabolic State of the Colon Microenvironment

Preet, R., & Dixon, D. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.01.021 · Cited by 4

Desperately Seeking Glucose

Kiberstis, P. A. (2009) · Science Signaling · doi:10.1126/scisignal.289ec312

Abstract B32: Mutant KRAS downregulates LIFR to enhance glycolysis in pancreatic cancer

Liu, S., Gandler, H. I., Walker, S. R., Ye, D. Q., Giaccone, Z. T., Nowak, J. A., Aguirre, A. J., Wolpin, B. M., & Frank, D. A. (2019) · Cancer Research · doi:10.1158/1538-7445.panca19-b32