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PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
Open accessAbstract
Toward Neuronal Regeneration: Neurons in the central nervous system that are severed or crushed do not regenerate well. Part of the problem derives from the glial scars left behind after such damage. The scar tissue contains sulfated proteoglycans that seem to inhibit axon regeneration. Shen et al. (p. 592 , published online 15 October) have now identified a protein tyrosine phosphatase (PTP) in mouse neuronal membranes that functions as a receptor for the proteoglycans. Neurons that lacked this particular PTP showed improved regeneration. Regeneration remained incomplete, presumably due to other inhibitory factors in the way of complete axon regeneration.
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“Specifically, CSPGs, and particularly their GAG moieties, may act by i) binding to a specific receptor; ii) blocking the growth-promoting activity of integrins; iii) presenting growth-inhibitory proteins.”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Shen et al., 2009
In the citing paper
“Known CS/CSPG receptors are: contactin-1 (Mikami et al., 2009), receptor protein tyrosine phosphatase sigma (RPTPσ; Shen et al., 2009), leukocyte common antigen-related phosphatase (LAR; Fisher et al., 2011) and Nogo receptor (NgR) 1 and 3 (Dickendesher et al., 2012).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Shen et al., 2009
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“RPTPσ can bind with high affinity to neurocan and aggrecan and strongly inhibits axon outgrowth and regeneration (Sapieha et al., 2005;Shen et al., 2009;Fry et al., 2010;Lang et al., 2015).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Shen et al., 2009
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Citations
Cites
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
Self-citationChondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Glial inhibition of CNS axon regeneration
Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,525
Self-citationSulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
Snow, D. M., Lemmon, V., Carrino, D. A., Caplan, A. I., & Silver, J. (1990) · Experimental Neurology · doi:10.1016/s0014-4886(05)80013-5 · Cited by 776
Self-citationRegeneration of adult axons in white matter tracts of the central nervous system
Davies, S. J. A., Fitch, M. T., Memberg, S. P., Hall, A. K., Raisman, G., & Silver, J. (1997) · Nature · doi:10.1038/37776 · Cited by 737
Self-citationNeumann, S., & Woolf, C. J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80755-2 · Cited by 659
Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells
Goldberg, J. L., Klassen, M. P., Hua, Y., & Barres, B. A. (2002) · Science · doi:10.1126/science.1068428 · Cited by 488
McKeon, R. J., Höke, A., & Silver, J. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1081 · Cited by 488
Self-citationNeurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes
Asher, R. A., Morgenstern, D. A., Fidler, P. S., Adcock, K. H., Oohira, A., Braistead, J. E., Levine, J. M., Margolis, R. U., ROGERS, J. H., & Fawcett, J. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02427.2000 · Cited by 482
Structural and functional recovery from early monocular deprivation in adult rats
Pizzorusso, T., Medini, P., Landi, S., Baldini, S., Berardi, N., & Maffei, L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602657103 · Cited by 367
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Ibata, K., & Yuzaki, M. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.03.011 · Cited by 18
Axonal Regeneration by Glycosaminoglycan
Sakamoto, K., Ozaki, T., & Kadomatsu, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.702179 · Cited by 17
Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery
Martin, K. R., Narang, P., Medina‐Franco, J. L., Meurice, N., & MacKeigan, J. P. (2013) · Methods · doi:10.1016/j.ymeth.2013.08.013 · Cited by 17
Sensory Axon Regeneration: A Review from an in vivo Imaging Perspective
Han, S. B., Kim, H., Skuba, A., Tessler, A. R., Ferguson, T. A., & Son, Y. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.3.83 · Cited by 17
Recovery after spinal cord injury by modulation of the proteoglycan receptor PTPσ
Rink, S., Arnold, D., Wöhler, A., Bendella, H., Meyer, C., Μanthou, M. E., Papamitsou, T., Sarıkçıoğlu, L., & Angelov, D. N. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.003 · Cited by 17
Epigenetic Regulation of WNT3A Enhancer during Regeneration of Injured Cortical Neurons
Chang, C.-Y., Hung, J., Huang, L.-W., Li, J., Fung, K. S., Kao, C.-F., & Chen, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051891 · Cited by 16
Central Versus Peripheral Nervous System Regeneration: Is There An Exception for Cranial Nerves?
Echternacht, S. R., Chacon, M. A., & Leckenby, J. I. (2021) · Regenerative Medicine · doi:10.2217/rme-2020-0096 · Cited by 16
Chemistry and Function of Glycosaminoglycans in the Nervous System
Schwartz, N. B., & Domowicz, M. S. (2022) · Advances in neurobiology · doi:10.1007/978-3-031-12390-0_5 · Cited by 17
Zhu, S., Ma, H., Hou, M., Li, H., & Ning, G. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04166-0 · Cited by 16
Sabatier, M. J., To, B. N., Rose, S. J., Nicolini, J., & ENGLISH, A. W. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00887.2011 · Cited by 16
Cyclin-Dependent Kinase 5 in Axon Growth and Regeneration
Ye, T., Fu, A. K. Y., & Ip, N. Y. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-398309-1.00006-8 · Cited by 17
Targeting cell surface receptors for axon regeneration in the central nervous system
Andrews, M. R., & Cheah, M. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.197079 · Cited by 16
Romereim, S. M., Johnston, C. A., Redwine, A. L., & Wachs, R. A. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24557 · Cited by 16
Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration
Kuboyama, T., Luo, X., Park, K. K., Blackmore, M. G., Tojima, T., Tohda, C., Bixby, J. L., Lemmon, V., & Kamiguchi, H. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.06.011 · Cited by 17
Carwardine, D. R., Wong, L., Fawcett, J. W., Muir, E. M., & Granger, N. P. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.06.011 · Cited by 18
Inflammatory Mediators of Axon Regeneration in the Central and Peripheral Nervous Systems
Benowitz, L. I., Xie, L., & Yin, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015359 · Cited by 15
Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies
Mamun, A. A., Zhou, Q., Geng, P., Wang, S., Shao, C., & Xiao, J. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70193 · Cited by 15
Neural Regeneration: Lessons from Regenerating and Non-regenerating Systems
Ferreira, L. M. R., Floriddia, E. M., Quadrato, G., & Giovanni, S. D. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8290-9 · Cited by 17
Chondroitin sulfates do not impede axonal regeneration in goldfish spinal cord
Takeda, A., Okada, S., & Funakoshi, K. (2017) · Brain Research · doi:10.1016/j.brainres.2017.08.004 · Cited by 15
Urban, M. W., Ghosh, B., Block, C. G., Charsar, B. A., Smith, G. M., Wright, M. C., Li, S., & Lepore, A. C. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6586 · Cited by 16
Mikami, T., & Kitagawa, H. (2023) · The Journal of Biochemistry · doi:10.1093/jb/mvac110 · Cited by 15
Scar-modulating treatments for central nervous system injury
Shen, D., Wang, X., & Gu, X. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1456-2 · Cited by 16
Park, H., Chien, P. N., & Ryu, S. E. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.08.081 · Cited by 15
Xia, Y., Yan, Y., Xia, H., Zhao, T., Chu, W., Hu, S., Feng, H., & Lin, J. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.073 · Cited by 15
Nagai, J., Takaya, R., Piao, W., Goshima, Y., & Ohshima, T. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.03.006 · Cited by 16
Enoxaparin promotes functional recovery after spinal cord injury by antagonizing PTPRσ
Ito, S., Ozaki, T., Morozumi, M., Imagama, S., Kadomatsu, K., & Sakamoto, K. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113679 · Cited by 17
Advances and Challenges for Neural Regeneration Research
Wang, X., So, K., & Xu, X. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801732-6.00001-x · Cited by 16
Gao, Y., Deng, K., Cao, Z., Graziani, E. I., Gilbert, A. M., Koehn, F. E., Wood, A., Doherty, P., & Walsh, F. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06704.x · Cited by 14
Zhong, J., Lan, C., Zhang, C., Yang, Y., Chen, W., Zhang, K., Zhao, H., Fang, X., Li, H., Tan, L., et al. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28379 · Cited by 14
Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells
Hirono, M., Karube, F., & Yanagawa, Y. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.661899 · Cited by 16
Albiñana, E., Luengo, J. G., Juárez, N. H., Baraibar, A. M., Montell, E., Vergés, J., Garcı́a, A. G., & Hernández-Guijo, J. M. (2015) · Neural Plasticity · doi:10.1155/2015/463854 · Cited by 14
Guiding migration of transplanted glial progenitor cells in the injured spinal cord
Yuan, X., Jin, Y., Haas, C., Yao, L., Hayakawa, K., Wang, Y., Wang, C., & Fischer, I. (2016) · Scientific Reports · doi:10.1038/srep22576 · Cited by 14
Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-Ig1-2
Gao, Q., Yang, J., Moremen, K. W., Flanagan, J. G., & Prestegard, J. H. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00241 · Cited by 14
Self-citationDyck, S. M., & Karimi‐Abdolrezaee, S. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.241452 · Cited by 16
Structural Basis for LAR-RPTP-Mediated Synaptogenesis.
Won, S. Y., & Kim, H. M. (2018) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0202 · Cited by 14
MicroRNA-mediated regulation of reactive astrocytes in central nervous system diseases
Fan, Y., Huang, H., Shao, J., & Huang, W. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1061343 · Cited by 13
PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer’s disease
Poirier, A., Picard, C., Labonté, A., Aubry, I., Auld, D. S., Zetterberg, H., Blennow, K., Poirier, J., Breitner, J. C. S., Poirier, A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65104-2 · Cited by 14
Biomimetic 3D Hydrogels with Aligned Topography for Neural Tissue Engineering
Severs, L. J., Katta, A., Cates, L. N., Dewees, D. M., Hoagland, R. T., Horner, P. J., Hofstetter, C. P., & Khaing, Z. Z. (2024) · Polymers · doi:10.3390/polym16243556 · Cited by 14
Need for a paradigm shift in therapeutic approaches to CNS injury
Wootla, B., Đenić, A., Warrington, A. E., & Rodriguez, M. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.24 · Cited by 13
Hering, T. M., Beller, J. A., Calulot, C. M., & Snow, D. M. (2020) · Biology · doi:10.3390/biology9020029 · Cited by 13
Cholesterol synthesis inhibition or depletion in axon regeneration
Tang, B. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.317956 · Cited by 12
Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form
Jeon, T. J., Chien, P. N., Chun, H., & Ryu, S. E. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0033-x · Cited by 13
Zhang, Q., Li, Y., & Zhuo, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02781-y · Cited by 13
A Review of the Potential Use of Antioxidants in Spinal Cord Injuries
Nowacka, A., Śniegocki, M., & Ziółkowska, E. (2025) · Antioxidants · doi:10.3390/antiox14091081 · Cited by 14
Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration
Siddiq, M. M., Hannila, S. S., Zorina, Y., Nikulina, E., Rabinovich, V., Hou, J., Huq, R., Richman, E. L., Tolentino, R. E., Hansen, J., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab271 · Cited by 12
Aberrant perineuronal nets alter spinal circuits, impair motor function, and increase plasticity
Sánchez-Ventura, J., Canal, C., Hidalgo, J., Penas, C., Navarro, X., Espin, A. T., Fouad, K., & Udina, E. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114220 · Cited by 12
Michel‐Flutot, P., Lane, M. A., Lepore, A. C., & Vinit, S. (2023) · Cells · doi:10.3390/cells12111519 · Cited by 13
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder
Fell, C. W., Hagelkrüys, A., Cicvaric, A., Horrer, M., Liu, L., Li, J. S. S., Stadlmann, J., Polyansky, A. A., Mereiter, S., Tejada, M. A., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202215829 · Cited by 13
Strategic Approaches to Regeneration of a Damaged Central Nervous System
Okano, H. (2011) · Cornea · doi:10.1097/ico.0b013e3182281879 · Cited by 12
Mechanisms of axon regeneration: The significance of proteoglycans
Sakamoto, K., & Kadomatsu, K. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.005 · Cited by 13
Semisynthesis of Chondroitin Sulfate E Tetrasaccharide from Hyaluronic Acid
Yao, W., Zhu, Y. L., Zhang, X., Meng, S., Meng, X., & Li, Z. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b01987 · Cited by 13
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Sharma, K., Zhang, G., & Li, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801732-6.00011-2 · Cited by 14
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Ramasamy, S., Yu, F., Yu, Y. H., Hariharan, S., Dawe, G. S., & Ahmed, S. (2014) · Stem Cells · doi:10.1002/stem.1645 · Cited by 14
Shimbo, M., Ando, S., Sugiura, N., Kimata, K., & Ichijo, H. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.011 · Cited by 12
PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC
Davis, T. B., Yang, M., Wang, H., Lee, C., Yeatman, T. J., & Pledger, W. J. (2019) · Oncotarget · doi:10.18632/oncotarget.27335 · Cited by 11
Glypican-2 defines age-dependent axonal response to chondroitin sulfate
Ouchida, J., Ozaki, T., Segi, N., Suzuki, Y., Imagama, S., Kadomatsu, K., & Sakamoto, K. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114444 · Cited by 12
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Hammond, B. P., Panda, S. P., Kaushik, D. K., & Plemel, J. R. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_25 · Cited by 11
Wu, C., Hardy, S., Aubry, I., Landry, M., Haggarty, A., Saragovi, H. U., & Tremblay, M. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178489 · Cited by 11
One Raft to Guide Them All, and in Axon Regeneration Inhibit Them
Hernaiz-Llorens, M., Martínez‐Mármol, R., Roselló-Busquets, C., & Soriano, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095009 · Cited by 13
Sekine, Y., Kannan, R., Wang, X., & Strittmatter, S. M. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114070 · Cited by 11
Xu, C., Wang, J., & Jin, W. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0538-1 · Cited by 11
Zou, J., Sun, J.-H., Qiu, S., Chen, S., He, F.-L., Li, J., Mao, H., Liu, X., Quan, D., Zeng, Y., et al. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.023 · Cited by 13
Identification of PTPRσ-interacting proteins by proximity-labelling assay
Gong, Y., Abudureyimu, S., Kadomatsu, K., & Sakamoto, K. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa141 · Cited by 11
Functional Analysis of the Putative Tumor SuppressorPTPRDin Neuroblastoma Cells
Clark, O., Schmidt, F., Coles, C. H., Tchetchelnitski, V., & Stoker, A. W. (2012) · Cancer Investigation · doi:10.3109/07357907.2012.675383 · Cited by 11
Agenesis of the corpus callosum in Nogo receptor deficient mice
Yoo, S., Motari, M. G., & Schnaar, R. L. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24064 · Cited by 10
Crystal and solution structures of fragments of the human leucocyte common antigen-related protein
Vilstrup, J., Simonsen, A., Birkefeldt, T., Strandbygaard, D., Lyngsø, J., Pedersen, J. S., & Thirup, S. (2020) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798320003885 · Cited by 11
Zhu, A., Jiang, Y., Pan, L., Li, J., Huang, Y., Shi, M., Di, L., Wang, L., & Wang, R. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.11.013 · Cited by 10
Liu, Z.-G., Zhou, L.-Y., Yong-quan, S., Ma, Y., Liu, C.-M., & Zhang, B.-Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2024.1526973 · Cited by 12
Sun, W., Dion, E., Laredo, F., Okonak, A., Sepeda, J. A., Haykal, E., Zhou, M., El‐Hodiri, H. M., Fischer, A. J., Silver, J., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.04.020 · Cited by 10
Self-citationSrinivasan, B., Marks, H., Mitra, S., Smalley, D. M., & Skolnick, J. (2016) · Biochemical Journal · doi:10.1042/bcj20160289 · Cited by 12
Long-Term Cultures of Spinal Cord Interneurons
Vargová, I., Kriška, J., Kwok, J. C. F., Fawcett, J. W., & Jendelová, P. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.827628 · Cited by 10
Low-Molecular Weight Protamine Overcomes Chondroitin Sulfate Inhibition of Neural Regeneration
Kulesskaya, N., Mugantseva, E., Minkeviciene, R., Acosta, N., Rouhiainen, A., Kuja‐Panula, J., Kislin, M., Piirainen, S., Paveliev, M., & Rauvala, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.865275 · Cited by 10
Zheng, W., Zhao, K., Song, L., Qian, Z., Liu, W., Zhu, Y., Mao, Z., & Gao, C. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149225 · Cited by 10
Shmal, D., Mantero, G., Floß, T., Benfenati, F., & Maya‐Vetencourt, J. F. (2024) · iScience · doi:10.1016/j.isci.2024.109507 · Cited by 10
Receptor protein tyrosine phosphatase σ binds to neurons in the adult mouse brain
Yi, J., Katagiri, Y., Yu, P., Lourie, J., Bangayan, N. J., Symes, A. J., & Geller, H. M. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.02.007 · Cited by 10
Wang, Y., Chen, M., Dou, X., Jin, H., Zhang, X., Zhu, Y. L., Meng, S., Liu, Z., Meng, X., Zhang, L., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.12.004 · Cited by 10
Guldager, M. B., Biojone, C., da Silva, N. R., Godoy, L. D., & Joca, S. R. L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111029 · Cited by 10
Hodgkinson, G. N., Tresco, P. A., & Hlady, V. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.046 · Cited by 9
Noborn, F., & Larson, G. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_485 · Cited by 9
Sethi, J., Zhao, B., Cuvillier‐Hot, V., Boidin‐Wichlacz, C., Salzet, M., Macagno, E. R., & Baker, M. W. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.002 · Cited by 9
Hryciw, T., Geremia, N. M., Walker, M. A., Xu, X., & Brown, A. M. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5928 · Cited by 9
Rodemer, W., Zhang, G., Sinitsa, I., Hu, J., Jin, L., Li, S., & Selzer, M. E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00061 · Cited by 9
Reelin Counteracts Chondroitin Sulfate Proteoglycan-Mediated Cortical Dendrite Growth Inhibition
Zluhan, E., Enck, J. R., Matthews, R. T., & Olson, E. C. (2020) · eNeuro · doi:10.1523/eneuro.0168-20.2020 · Cited by 10
Ritchie, C. (2012) · Materials and Methods · doi:10.13070/mm.en.2.134 · Cited by 9
Wen, R., Long, G., He, X., Zhang, K., Ma, W., Shen, Y., Xiao, Z., Zhao, Y., Liu, D., Dai, J., et al. (2024) · Theranostics · doi:10.7150/thno.103033 · Cited by 8
Self-citationNeuroglia and extracellular matrix molecules
Dzyubenko, E., & Hermann, D. M. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00010-3 · Cited by 8
Recent advances in regenerative medicine approaches for spinal cord injuries
Hettiaratchi, M. H., Führmann, T., & Shoichet, M. S. (2017) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2017.08.002 · Cited by 7
Hou, L., Wang, J., Zhou, Y., Li, J., Zang, Y., & Li, J. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr095 · Cited by 8
Berillo, O., Huo, K.-G., Richer, C., Fraulob-Aquino, J. C., Briet, M. B., Lipman, M. L., Sinnett, D., Paradis, P., & Schiffrin, E. L. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003160 · Cited by 9
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Abu-Rub, M., Newland, B., Naughton, M., Wang, W., McMahon, S. S., & Pandit, A. S. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.026 · Cited by 8
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Metadata
- Authors
- Shen, Y., Tenney, A. P., Busch, S. A., Horn, K. P., Cuascut, F. X., Liu, K., He, Z., Silver, J., & Flanagan, J. G.
- Affiliations
- Harvard University (US)
- Case Western Reserve University (US)
- Boston Children's Hospital (US)
- Corresponding author
- Shen, Yingjie
- Tenney, Alan P.
- Flanagan, John G.
- Venue
- Science
- Published
- 2009-10-23
- Volume
- 326
- Issue
- 5952
- Pages
- 592-596
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2811318
- OpenAlex
- W2043930451
- Cited by
- 682
- References
- 36
- Citations by year
- 2026: 23 · 2025: 29 · 2024: 31 · 2023: 30 · 2022: 34 · 2021: 41 · 2020: 40 · 2019: 32 · 2018: 45 · 2017: 43 · 2016: 35 · 2015: 53 · 2014: 63 · 2013: 57 · 2012: 59
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R01EY011559)
- National Institute of Neurological Disorders and Stroke (R37NS025713, R01NS025713)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD029417)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- PTPσ, chondroitin sulfate proteoglycans, axon regeneration, nerve regeneration, spinal cord injury, immunoglobulin-like domains, gene disruption, neuroprotection
- MeSH terms
- Animals, Astrocytes, Axons, Binding Sites, Cells, Cultured, Chondroitin Sulfates, Female, Ganglia, Spinal, Ligands, Nerve Regeneration, Nerve Tissue Proteins, Neurons, Protein Binding, Chondroitin Sulfate Proteoglycans, Proteoglycans, Recombinant Fusion Proteins, Spinal Cord, Spinal Cord Injuries, Neurites, Mice, Aggrecans, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Protein Interaction Domains and Motifs, Neurocan
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