Cited by 686Nerve injury and regenerationProteoglycans and glycosaminoglycans researchSpinal Cord Injury Research

The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.

PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

Open access

Shen, Yingjie, Tenney, Alan P., Busch, Sarah A., Horn, Kevin P., Cuascut, Fernando X., Liu, Kai, He, Zhigang, Silver, Jerry, Flanagan, John G.·2009·Science

DOI 10.1126/science.1178310PMC PMC2811318

Open this paper in CoChat — free account

Abstract

Toward Neuronal Regeneration: Neurons in the central nervous system that are severed or crushed do not regenerate well. Part of the problem derives from the glial scars left behind after such damage. The scar tissue contains sulfated proteoglycans that seem to inhibit axon regeneration. Shen et al. (p. 592 , published online 15 October) have now identified a protein tyrosine phosphatase (PTP) in mouse neuronal membranes that functions as a receptor for the proteoglycans. Neurons that lacked this particular PTP showed improved regeneration. Regeneration remained incomplete, presumably due to other inhibitory factors in the way of complete axon regeneration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1178310

Cites

35 of 36 references verified1 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
Self-citation
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Glial inhibition of CNS axon regeneration
Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,525
Self-citation
Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
Snow, D. M., Lemmon, V., Carrino, D. A., Caplan, A. I., & Silver, J. (1990) · Experimental Neurology · doi:10.1016/s0014-4886(05)80013-5 · Cited by 776
Self-citation
Regeneration of adult axons in white matter tracts of the central nervous system
Davies, S. J. A., Fitch, M. T., Memberg, S. P., Hall, A. K., Raisman, G., & Silver, J. (1997) · Nature · doi:10.1038/37776 · Cited by 737
Self-citation
Regeneration of Dorsal Column Fibers into and beyond the Lesion Site following Adult Spinal Cord Injury
Neumann, S., & Woolf, C. J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80755-2 · Cited by 659
Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells
Goldberg, J. L., Klassen, M. P., Hua, Y., & Barres, B. A. (2002) · Science · doi:10.1126/science.1068428 · Cited by 488
Injury-Induced Proteoglycans Inhibit the Potential for Laminin-Mediated Axon Growth on Astrocytic Scars
McKeon, R. J., Höke, A., & Silver, J. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1081 · Cited by 488
Self-citation
Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes
Asher, R. A., Morgenstern, D. A., Fidler, P. S., Adcock, K. H., Oohira, A., Braistead, J. E., Levine, J. M., Margolis, R. U., ROGERS, J. H., & Fawcett, J. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02427.2000 · Cited by 482
Structural and functional recovery from early monocular deprivation in adult rats
Pizzorusso, T., Medini, P., Landi, S., Baldini, S., Berardi, N., & Maffei, L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602657103 · Cited by 367

Show all 36 references

Sorted by citations

Items 201–300 of 686

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth
Li, H., Kuwajima, T., Oakley, D. H., Nikulina, E., Hou, J., Yang, W. S., Lowry, E. R., Lamas, N. J., Mathis, M. W., Croft, G. F., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.013 · Cited by 57
Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate
Hayes, A. J., & Melrose, J. (2018) · Biochemical Journal · doi:10.1042/bcj20180283 · Cited by 58
Roles of glycosaminoglycans as regulators of ligand/receptor complexes
Smock, R. G., & Meijers, R. (2018) · Open Biology · doi:10.1098/rsob.180026 · Cited by 56
Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons
Lesnikova, A., Casarotto, P. C., Fred, S. M., Voipio, M., Winkel, F., Steinzeig, A., Antila, H., Umemori, J., Biojone, C., & Castrén, E. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2228-20.2020 · Cited by 56
A Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation
Brooks, J. M., Su, J., Levy, C., Wang, J. S., Seabrook, T. A., Guido, W., & Fox, M. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.09.041 · Cited by 55
CLAC-P/Collagen Type XXV Is Required for the Intramuscular Innervation of Motoneurons during Neuromuscular Development
Tanaka, T., Wakabayashi, T., Oizumi, H., NISHIO, S., Sato, T., Harada, A., Fujii, D., Matsuo, Y., Hashimoto, T., & Iwatsubo, T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2440-13.2014 · Cited by 56
Neuronal Redevelopment and the Regeneration of Neuromodulatory Axons in the Adult Mammalian Central Nervous System
Cooke, P., Janowitz, H. N., & Dougherty, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.872501 · Cited by 61
HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix
Paveliev, M., Fenrich, K. K., Kislin, M., Kuja‐Panula, J., Kulesskiy, E., Varjosalo, M. T., Kajander, T., Mugantseva, E., Ahonen-Bishopp, A., Khiroug, L., et al. (2016) · Scientific Reports · doi:10.1038/srep33916 · Cited by 55
Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury
DePaul, M. A., Lin, C., Silver, J., & Lee, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-09432-6 · Cited by 55
Self-citation
An in vitro assay to study induction of the regenerative state in sensory neurons
Frey, E. N., Valakh, V., Karney-Grobe, S., Shi, Y., Milbrandt, J., & DiAntonio, A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.012 · Cited by 52
In vitro models of axon regeneration
Al‐Ali, H., Beckerman, S. R., Bixby, J. L., & Lemmon, V. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.01.020 · Cited by 60
Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury
Tran, A. P., Warren, P. M., & Silver, J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113276 · Cited by 52
Self-citation
LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain
Cornejo, F., Cortés, B. I., Findlay, G. M., & Cancino, G. I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.659951 · Cited by 54
Axonal degeneration, regeneration and ganglion cell death in a rodent model of anterior ischemic optic neuropathy (rAION)
Zhang, C., Guo, Y., Slater, B. J., Miller, N. R., & Bernstein, S. L. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.05.021 · Cited by 53
p53 Regulates the Neuronal Intrinsic and Extrinsic Responses Affecting the Recovery of Motor Function following Spinal Cord Injury
Floriddia, E. M., Rathore, K. I., Tedeschi, A., Quadrato, G., Wuttke, A., Lueckmann, J.-M., Kigerl, K. A., Popovich, P. G., & Giovanni, S. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1925-12.2012 · Cited by 51
Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase
Takahashi, K., Mernaugh, R. L., Friedman, D. B., Weller, R., Tsuboi, N., Yamashita, H., Quaranta, V., & Takahashi, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106171109 · Cited by 55
Targeted downregulation of N‐acetylgalactosamine 4‐sulfate 6‐O‐sulfotransferase significantly mitigates chondroitin sulfate proteoglycan‐mediated inhibition
Karumbaiah, L., Anand, S., Thazhath, R., Zhong, Y., McKeon, R. J., & Bellamkonda, R. V. (2011) · Glia · doi:10.1002/glia.21170 · Cited by 53
Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor–induced epithelial‐mesenchymal transition
Wang, Z., Gao, Q., Shi, J.-Y., Guo, W., Yang, L., Liu, X., Liu, L., Ma, L., Duan, M., Zhao, Y., et al. (2015) · Hepatology · doi:10.1002/hep.27911 · Cited by 53
Protein tyrosine phosphatases in cell adhesion
Young, K. A., Biggins, L., & Sharpe, H. J. (2021) · Biochemical Journal · doi:10.1042/bcj20200511 · Cited by 51
BDNF receptor TrkB as the mediator of the antidepressant drug action
Casarotto, P. C., Umemori, J., & Ċastrén, E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1032224 · Cited by 53
Thy-1-Interacting Molecules and Cellular Signaling in Cis and Trans
Herrera‐Molina, R., Valdivia, A., Kong, M., Álvarez, Á., Cárdenas, A., Quest, A. F. G., & Leyton, L. (2013) · International review of cytology · doi:10.1016/b978-0-12-407695-2.00004-4 · Cited by 51
RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model
Gwak, S., Macks, C. P., Jeong, D. U., Kindy, M. S., Lynn, M., Webb, K., & Lee, J. S. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.003 · Cited by 51
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway
Li, Z., Yu, S., Liu, Y., Hu, X., Li, Y., Xiao, Z., Chen, Y., Tian, D., Xu, X., Cheng, L., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02449-3 · Cited by 49
The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage
Li, H., Ghorbani, S., Ling, C., Yong, V. W., & Xue, M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106282 · Cited by 52
Neuroplasticity of spinal cord injury and repair
Martin, J. H. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00017-5 · Cited by 54
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
Kim, H. Y., Um, J. W., & Ko, J. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101983 · Cited by 51
Receptor‐type tyrosine phosphatase ligands: looking for the needle in the haystack
Mohebiany, A. N., Nikolaienko, R. M., Bouyain, S., & Harroch, S. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08653.x · Cited by 48
Proteoglycans: Road Signs for Neurite Outgrowth
Snow, D., & Beller, J. A. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.128235 · Cited by 50
Extravascular CX3CR1+Cells Extend Intravascular Dendritic Processes into Intact Central Nervous System Vessel Lumen
Barkauskas, D. S., Evans, T. A., Myers, J., Petrošiūtė, A., Silver, J., & Huang, A. Y.-C. (2013) · Microscopy and Microanalysis · doi:10.1017/s1431927613000482 · Cited by 50
Self-citation
Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture
Yu, P., Jin, J., Tilve, S. M., Huang, Z., Zhou, L., & Geller, H. M. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.226398 · Cited by 48
Combinatorial Therapy Stimulates Long-Distance Regeneration, Target Reinnervation, and Partial Recovery of Vision After Optic Nerve Injury in Mice
de Lima, S., Habboub, G., & Benowitz, L. I. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-407178-0.00007-7 · Cited by 47
Enhanced regeneration and functional recovery after spinal root avulsion by manipulation of the proteoglycan receptor PTPσ
Li, H., Wong, C. W., Li, W., Ruven, C., He, L., Wu, X., Lang, B. T., Silver, J., & Wu, W. (2015) · Scientific Reports · doi:10.1038/srep14923 · Cited by 47
Self-citation
Chondroitin Sulfate Proteoglycans Down-regulate Spine Formation in Cortical Neurons by Targeting Tropomyosin-related Kinase B (TrkB) Protein
Kurihara, D., & Yamashita, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.314070 · Cited by 50
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment
Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42339-7 · Cited by 42
Myosin II activity regulates neurite outgrowth and guidance in response to chondroitin sulfate proteoglycans
Yu, P., Santiago, L. Y., Katagiri, Y., & Geller, H. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07638.x · Cited by 45
Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS
Hirano, K., Ohgomori, T., Kobayashi, K., Tanaka, F., Matsumoto, T., Natori, T., Matsuyama, Y., Uchimura, K., Sakamoto, K., Takeuchi, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066969 · Cited by 45
Targets for Neural Repair Therapies After Stroke
Carmichael, S. T. (2010) · Stroke · doi:10.1161/strokeaha.110.597146 · Cited by 45
The challenges of long-distance axon regeneration in the injured CNS
Chew, D. J., Fawcett, J. W., & Andrews, M. R. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59544-7.00013-5 · Cited by 43
The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma
Huang, Y., Zhang, Y., Ge, L., Lin, Y., & Kwok, H. F. (2018) · Cancers · doi:10.3390/cancers10030082 · Cited by 47
Comparison of subacute and chronic scar tissues after complete spinal cord transection
Li, X., Yang, B., Xiao, Z., Zhao, Y., Han, S., Yin, Y., Chen, B., & Dai, J. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.008 · Cited by 46
The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition
Ketschek, A., Haas, C., Gallo, G., & Fischer, I. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.03.017 · Cited by 44
Genetic dissection of axon regeneration
Wang, Z., & Jin, Y. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.010 · Cited by 44
Transforming growth factor β-induced expression of chondroitin sulfate proteoglycans is mediated through non-Smad signaling pathways
Jahan, N., & Hannila, S. S. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.023 · Cited by 44
Comprehensive Corticospinal Labeling withmu-crystallinTransgene Reveals Axon Regeneration after Spinal Cord Trauma inngr1−/−Mice
Fink, K. L., Strittmatter, S. M., & Cafferty, W. B. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3165-15.2015 · Cited by 43
Enhancing Spinal Plasticity Amplifies the Benefits of Rehabilitative Training and Improves Recovery from Stroke
Wiersma, A. M., Fouad, K., & Winship, I. R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0770-17.2017 · Cited by 44
The nuclear events guiding successful nerve regeneration
Kiryu‐Seo, S., & Kiyama, H. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00053 · Cited by 43
Cell Therapeutic Strategies for Spinal Cord Injury
Zhou, P., Guan, J., Xu, P., Zhao, J., Zhang, C., Zhang, B., Mao, Y., & Cui, W. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.1046 · Cited by 42
Mechanisms and repair strategies for white matter degeneration in CNS injury and diseases
Shahsavani, N., Kataria, H., & Karimi‐Abdolrezaee, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166117 · Cited by 43
Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation
Vajn, K., Plunkett, J. A., Tapanes-Castillo, A., & Oudega, M. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1361-8 · Cited by 43
Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury
Mukherjee, N., Nandi, S., Garg, S., Ghosh, S., Ghosh, S., Samat, R., & Ghosh, S. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00004 · Cited by 43
Regulation of oligodendrocyte precursor maintenance by chondroitin sulphate glycosaminoglycans
Karus, M., Ulc, A., Ehrlich, M., Czopka, T., Hennen, E., Fischer, J., Mizhorova, M., Qamar, N., Brüstle, O., & Faissner, A. (2015) · Glia · doi:10.1002/glia.22928 · Cited by 45
LAR Receptor Tyrosine Phosphatases and HSPGs Guide Peripheral Sensory Axons to the Skin
Wang, F., Wolfson, S. N., Gharib, A., & Sagasti, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.01.040 · Cited by 42
Neural ECM and synaptogenesis
Heikkinen, A., Pihlajaniemi, T., Faissner, A., & Yuzaki, M. (2014) · Progress in Brain Research · doi:10.1016/b978-0-444-63486-3.00002-5 · Cited by 42
Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans
Rauvala, H., Paveliev, M., Kuja‐Panula, J., & Kulesskaya, N. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.206630 · Cited by 45
Mesenchymal stem cells for regenerative medicine in central nervous system
Li, M., Chen, H., & Zhu, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1068114 · Cited by 42
Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice
Kauhausen, J. A., Thompson, L. H., & Parish, C. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.243063 · Cited by 41
Proteoglycans and axon guidance: a new relationship between old partners
Masu, M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13508 · Cited by 44
Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex
Boggio, E. M., Ehlert, E. M., Lupori, L., Moloney, E. B., De Winter, F., Vander Kooi, C. W., Baroncelli, L., Mecollari, V., Blits, B., Fawcett, J. W., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1499-0 · Cited by 41
Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods
Igarashi, M. (2019) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.95.026 · Cited by 40
Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Block Distinct Steps in Transendothelial Migration of Effector Memory CD4+ T Cells by Targeting Different Endothelial Proteins
Manes, T. D., Hoer, S., Müller, W. A., Lehner, P. J., & Pober, J. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902938 · Cited by 40
Chondroitin Sulfate Synthase-2 Is Necessary for Chain Extension of Chondroitin Sulfate but Not Critical for Skeletal Development
Ogawa, H., Hatano, S., Sugiura, N., Nagai, N., Sato, T., Shimizu, K., Kimata, K., Narimatsu, H., & Watanabe, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043806 · Cited by 40
Cathepsins in neuronal plasticity
Silver, J., & Tran, A. P. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.286948 · Cited by 40
Self-citation
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke
Luo, F., Wang, J., Zhang, Z., You, Z., Bedolla, A., Okwubido-Williams, F. V., Huang, L. F., Silver, J., & Luo, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111137 · Cited by 39
Self-citation
Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury
Zou, Y., Stagi, M., Wang, X., Yiğitkanlı, K., Siegel, C., Nakatsu, F., Cafferty, W. B. J., & Strittmatter, S. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1718-15.2015 · Cited by 38
Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration
Brochier, C., Jones, J. I., Willis, D. E., & Langley, B. C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509754112 · Cited by 39
Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology
Luca, C. D., & Papa, M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.04.002 · Cited by 39
Strategies to neutralize RhoA/ROCK pathway after spinal cord injury
Roy, A., Pathak, Z., & Kumar, H. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113794 · Cited by 39
The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases
Dong, Y., Zhao, K., Qin, X., Du, G., & Gao, L. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102092 · Cited by 39
Extrinsic and intrinsic regulation of axon regeneration at a crossroads
Kaplan, A., Tone, S. O., & Fournier, A. E. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00027 · Cited by 40
Chondroitin Sulfate Is a Crucial Determinant for Skeletal Muscle Development/Regeneration and Improvement of Muscular Dystrophies
Mikami, T., Koyama, S., Yabuta, Y., & Kitagawa, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336925 · Cited by 38
Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes
Su, Z., Kishida, S., Tsubota, S., Sakamoto, K., Cao, D., Kiyonari, S., Ohira, M., Kamijo, T., Narita, A., Xu, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22435 · Cited by 38
Regenerative medicine strategies for chronic complete spinal cord injury
Hashimoto, S., Nagoshi, N., Nakamura, M., & Okano, H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382230 · Cited by 37
The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour
Farrugia, B. L., & Melrose, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814101 · Cited by 39
Biomaterial Approaches to Enhancing Neurorestoration after Spinal Cord Injury: Strategies for Overcoming Inherent Biological Obstacles
Siebert, J. R., Eade, A. M., & Osterhout, D. J. (2015) · BioMed Research International · doi:10.1155/2015/752572 · Cited by 40
Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems
Ohtake, Y., Saito, A., & Li, S. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.01.014 · Cited by 39
The potential of memory enhancement through modulation of perineuronal nets
Duncan, J. A., Foster, R., & Kwok, J. C. F. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14672 · Cited by 41
Neurocan Contributes to Perineuronal Net Development
Schmidt, S., Arendt, T., Morawski, M., & Sonntag, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.040 · Cited by 36
Astrocytes in the Traumatic Brain Injury: the Good and the Bad
Yuan, M., & Wu, H. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113943 · Cited by 39
PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition
Shim, S.-O., Cafferty, W. B. J., Schmidt, E. F., Kim, B. G., Fujisawa, H., & Strittmatter, S. M. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.04.007 · Cited by 37
Retinoic acid signaling in axonal regeneration
Puttagunta, R., & Giovanni, S. D. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00059 · Cited by 40
From molecules to behavior: Implications for perineuronal net remodeling in learning and memory
Sanchez, B., Kraszewski, P., Lee, S., & Cope, E. C. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16036 · Cited by 41
Glioma cell invasion is significantly enhanced in composite hydrogel matrices composed of chondroitin 4- and 4,6-sulfated glycosaminoglycans
Logun, M. T., Bisel, N. S., Tanasse, E. A., Zhao, W., Gunasekera, B., Mao, L., & Karumbaiah, L. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01083k · Cited by 37
Rewiring the spinal cord: Direct and indirect strategies
Dell’Anno, M. T., & Strittmatter, S. M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.002 · Cited by 36
A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration
Sekine, Y., Lindborg, J. A., & Strittmatter, S. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009896 · Cited by 36
Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder
Munezane, H., Oizumi, H., Wakabayashi, T., NISHIO, S., Hirasawa, T., Sato, T., Harada, A., Yoshida, T., Eguchi, T., Yamanashi, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.112 · Cited by 36
Rho Signaling and Axon Regeneration
McKerracher, L. J., Ferraro, G. B., & Fournier, A. E. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-398309-1.00007-x · Cited by 35
Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses
Coles, C. H., Jones, E. Y., & Aricescu, A. R. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.007 · Cited by 37
Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth
Griffith, A. R., Rogers, C. J., Miller, G. M., Abrol, R., Hsieh‐Wilson, L. C., & Goddard, W. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715093115 · Cited by 35
M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury
Yu, S.-S., Li, Z.-Y., Xu, X.-Z., Yao, F., Luo, Y., Liu, Y.-C., Li, C., Zheng, M., & Jing, J. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.324858 · Cited by 35
Signaling mechanisms that coordinate the development and maintenance of dendritic fields
Emoto, K. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.04.005 · Cited by 35
Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?
Senis, Y. A., & Barr, A. (2018) · Molecules · doi:10.3390/molecules23030569 · Cited by 36
Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration
Sekiya, T., Holley, M. C., Hashido, K., Ono, K., Shimomura, K., Horie, R. T., Hamaguchi, K., Yoshida, A., Sakamoto, T., & Ito, J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501835112 · Cited by 33
Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons
Mohan, V., Wyatt, E. V., Gotthard, I., Phend, K. D., Diestel, S., Duncan, B. W., Weinberg, R. J., Tripathy, A., & Maness, P. F. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00346 · Cited by 34
A New Role for RPTPσ in Spinal Cord Injury: Signaling Chondroitin Sulfate Proteoglycan Inhibition
Duan, Y., & Giger, R. J. (2010) · Science Signaling · doi:10.1126/scisignal.3110pe6 · Cited by 34
Investigation of glycosaminoglycan mimetic scaffolds for neurite growth
Menezes, R., Hashemi, S., Vincent, R., Collins, G. L., Meyer, J., Foston, M. B., & Arinzeh, T. L. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.03.024 · Cited by 33
PTPσ inhibitors promote hematopoietic stem cell regeneration
Zhang, Y., Roos, M. M., Himburg, H. A., Termini, C. M., Quarmyne, M., Li, M., Zhao, L., Kan, J., Fang, T., Xiao, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11490-5 · Cited by 33
Mimicking Extracellular Matrix via Engineered Nanostructured Biomaterials for Neural Repair
Raspa, A., & Gelain, F. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666201111111102 · Cited by 36
Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation
Chambel, S. S., & Cruz, C. D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.373674 · Cited by 36
Surfen‐mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion
Logun, M. T., Wynens, K. E., Simchick, G. A., Zhao, W., Mao, L., Zhao, Q. C., Mukherjee, S., Brat, D. J., & Karumbaiah, L. (2019) · The FASEB Journal · doi:10.1096/fj.201802610rr · Cited by 32
Anisotropic Alginate Hydrogels Promote Axonal Growth across Chronic Spinal Cord Transections after Scar Removal
Huang, L., Wang, Y., Zhu, M., Wan, X., Zhang, H., Lei, T., Blesch, A., & Liu, S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01802 · Cited by 32

Authors: Shen, Y., Tenney, A. P., Busch, S. A., Horn, K. P., Cuascut, F. X., Liu, K., He, Z., Silver, J., & Flanagan, J. G.
Affiliations: Harvard University (US)
Case Western Reserve University (US)
Boston Children's Hospital (US)
Corresponding author: Shen, Yingjie
Tenney, Alan P.
Flanagan, John G.
ORCID: Shen, Yingjie
Horn, Kevin P.
Liu, Kai
He, Zhigang
Silver, Jerry
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-10-23
Volume: 326
Issue: 5952
Pages: 592-596
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1178310
PMC: PMC2811318
OpenAlex: W2043930451
Cited by: 682
References: 36
Citations by year: 2026: 23 · 2025: 29 · 2024: 31 · 2023: 30 · 2022: 34 · 2021: 41 · 2020: 40 · 2019: 32 · 2018: 45 · 2017: 43 · 2016: 35 · 2015: 53 · 2014: 63 · 2013: 57 · 2012: 59
FWCI: 17.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Eye Institute (R01EY011559)
National Institute of Neurological Disorders and Stroke (R37NS025713, R01NS025713)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD029417)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Keywords: PTPσ, chondroitin sulfate proteoglycans, axon regeneration, nerve regeneration, spinal cord injury, immunoglobulin-like domains, gene disruption, neuroprotection
MeSH terms: Animals, Astrocytes, Axons, Binding Sites, Cells, Cultured, Chondroitin Sulfates, Female, Ganglia, Spinal, Ligands, Nerve Regeneration, Nerve Tissue Proteins, Neurons, Protein Binding, Chondroitin Sulfate Proteoglycans, Proteoglycans, Recombinant Fusion Proteins, Spinal Cord, Spinal Cord Injuries, Neurites, Mice, Aggrecans, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Protein Interaction Domains and Motifs, Neurocan

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks