Cited by 686Nerve injury and regenerationProteoglycans and glycosaminoglycans researchSpinal Cord Injury Research

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PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

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Shen, Yingjie, Tenney, Alan P., Busch, Sarah A., Horn, Kevin P., Cuascut, Fernando X., Liu, Kai, He, Zhigang, Silver, Jerry, Flanagan, John G.·2009·Science

DOI 10.1126/science.1178310PMC PMC2811318

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Abstract

Toward Neuronal Regeneration: Neurons in the central nervous system that are severed or crushed do not regenerate well. Part of the problem derives from the glial scars left behind after such damage. The scar tissue contains sulfated proteoglycans that seem to inhibit axon regeneration. Shen et al. (p. 592 , published online 15 October) have now identified a protein tyrosine phosphatase (PTP) in mouse neuronal membranes that functions as a receptor for the proteoglycans. Neurons that lacked this particular PTP showed improved regeneration. Regeneration remained incomplete, presumably due to other inhibitory factors in the way of complete axon regeneration.

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Authors: Shen, Y., Tenney, A. P., Busch, S. A., Horn, K. P., Cuascut, F. X., Liu, K., He, Z., Silver, J., & Flanagan, J. G.
Affiliations: Harvard University (US)
Case Western Reserve University (US)
Boston Children's Hospital (US)
Corresponding author: Shen, Yingjie
Tenney, Alan P.
Flanagan, John G.
ORCID: Shen, Yingjie
Horn, Kevin P.
Liu, Kai
He, Zhigang
Silver, Jerry
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-10-23
Volume: 326
Issue: 5952
Pages: 592-596
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1178310
PMC: PMC2811318
OpenAlex: W2043930451
Cited by: 682
References: 36
Citations by year: 2026: 23 · 2025: 29 · 2024: 31 · 2023: 30 · 2022: 34 · 2021: 41 · 2020: 40 · 2019: 32 · 2018: 45 · 2017: 43 · 2016: 35 · 2015: 53 · 2014: 63 · 2013: 57 · 2012: 59
FWCI: 17.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Eye Institute (R01EY011559)
National Institute of Neurological Disorders and Stroke (R37NS025713, R01NS025713)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD029417)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Keywords: PTPσ, chondroitin sulfate proteoglycans, axon regeneration, nerve regeneration, spinal cord injury, immunoglobulin-like domains, gene disruption, neuroprotection
MeSH terms: Animals, Astrocytes, Axons, Binding Sites, Cells, Cultured, Chondroitin Sulfates, Female, Ganglia, Spinal, Ligands, Nerve Regeneration, Nerve Tissue Proteins, Neurons, Protein Binding, Chondroitin Sulfate Proteoglycans, Proteoglycans, Recombinant Fusion Proteins, Spinal Cord, Spinal Cord Injuries, Neurites, Mice, Aggrecans, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Protein Interaction Domains and Motifs, Neurocan

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PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

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