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Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin
Abstract
Recruiting the Components for Cell Division: A complete chromosome set must be apportioned to each daughter cell during cell division. A number of molecular mechanisms check that chromosome pairs or homologs are correctly aligned and attached to microtubules just before they separate to the two daughters; their spatial orientation ensures an even inheritance of the genome. One critical component of this system is the protein kinase Bub1. Kawashima et al. (p. 172 , see the Perspective by Javerzat ; published online 19 November) now show that the main substrate for Bub1 kinase activity in fission yeast is the chromatin protein histone H2A. Phosphorylation of H2A recruits the shugoshin proteins to chromatin, and especially to centromeres, where they also act to ensure correct chromosome segregation. This link between Bub1, histone H2A phosphorylation, and shugoshin is conserved in budding yeast and mammalian cells.
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Cites
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
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Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation
Yamagishi, Y., Honda, T., Tanno, Y., & Watanabe, Y. (2010) · Science · doi:10.1126/science.1194498 · Cited by 466
Self-citationSensing centromere tension: Aurora B and the regulation of kinetochore function
Lampson, M. A., & Cheeseman, I. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.10.007 · Cited by 375
Cohesin and its regulation: on the logic of X-shaped chromosomes
Haarhuis, J. H. I., Elbatsh, A. M. O., & Rowland, B. D. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.09.010 · Cited by 147
Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres
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Metadata
- Authors
- Kawashima, S. A., Yamagishi, Y., Honda, T., Ishiguro, K.-I., & Watanabe, Y.
- Venue
- Science
- Published
- 2010-01-08
- Volume
- 327
- Issue
- 5962
- Pages
- 172-177
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079321797
- Cited by
- 476
- References
- 1
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kawashima, S. A., Yamagishi, Y., Honda, T., Ishiguro, K.-I., & Watanabe, Y. (2010). Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin. Science. https://doi.org/10.1126/science.1180189
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